scholarly journals Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry

2005 ◽  
Vol 13 (4) ◽  
pp. 406-412 ◽  
Author(s):  
Marcelo Macedo Crivelini ◽  
Ana Maria Pires Soubhia ◽  
Renata Callestini Felipini
Keyword(s):  
Benign Lesion ◽  
Collagen Iv ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Dental Follicle ◽  
Luminal Surface ◽  
Immunohistochemical Detection ◽  
Enamel Epithelium ◽  
The Subject ◽  
Reduced Enamel Epithelium

The adenomatoid odontogenic tumor (AOT) is a clinically benign lesion. Discussions about the AOT hamartomatous or neoplastic nature, and the probable odontogenic epithelial cell it originates from still exist. This research aimed to study and discuss the subject by the immunohistochemical detection of cytokeratins, laminin, collagen IV, PCNA and p53 in 8 tumor samples and 8 dental follicle samples containing reduced enamel epithelium. The results have shown that CK14 labelling indicated differentiation grades for secreting ameloblasts or ameloblasts in the post-secreting stage in the adenomatoid structure of AOT. Laminin, found on the luminal surface of adenomatoid structures, was compatible with the reduced enamel epithelium during the "protective stage of amelogenesis". PCNA specifically labelled the spindled areas and peripheral cords of the AOT, indicating that these areas are responsible for tumor growth. After considerations about pathogenesis, the authors suggested that the nature of AOT is hamartomatous with histogenesis from the reduced enamel epithelium.

scholarly journals A RECENT UPDATE ON HISTOGENESIS OF ADENOMATOID ODONTOGENIC TUMOR: A REVIEW

2019 ◽  
pp. 55-62
Author(s):  
SAHANAZ P AHMED ◽  
NANDAKUMAR ARULMOZHI ◽  
RAMADAS RAMYA ◽  
KRISHNAKUMAR KARUNYA
Keyword(s):  
Odontogenic Tumor ◽  
Biological Behavior ◽  
Adenomatoid Odontogenic Tumor ◽  
Epithelial Tumor ◽  
Dental Lamina ◽  
Ultrastructural Studies ◽  
Root Sheath ◽  
Odontogenic Epithelium ◽  
Odontogenic Origin ◽  
Enamel Epithelium

Adenomatoid odontogenic tumor (AOT) is a relatively rare benign, epithelial tumor of odontogenic origin. There is varying class of thoughts contemplating this lesion to be a hamartoma or neoplastic growth of odontogenic epithelium. Controversy regarding the histogenesis of the lesion is plentiful in earlier literature. The recent advent of immunohistochemical and ultrastructural studies has aided in throwing light on the tissue of origin of this tumor. This review aims at understanding the evolving concepts of histogenesis of AOT to better understand the biological behavior of the lesion. The review of AOT was carried out using PubMed and Google Scholar databases and 39 articles from the year 2001 to 2016 which contributed to the histogenesis of AOT were included for review. Since the origin of the cystic lining is similar to a reduced enamel epithelium and not the dental lamina, we propose the former to be the progenitor of AOT. Furthermore, we consider extra-follicular, as well as peripheral AOTs, originate from the remnants of Hertwig’s epithelial root sheath (epithelial rests of Malassez), which complies with the common histology for all these variants.

scholarly journals Adenomatoid odontogenic tumor: Immunohistochemical detection of intermediate filament proteins.

1989 ◽  
Vol 35 (12) ◽  
pp. 2827-2831 ◽  
Author(s):  
Katsumi UNO ◽  
Akihide KAMEGAI ◽  
Norimasa SHIMAMURA ◽  
Shinsaku MATSUMAE ◽  
Tosi-ichirou TANABE ◽  
...  
Keyword(s):  
Intermediate Filament ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Immunohistochemical Detection ◽  
Intermediate Filament Proteins

scholarly journals Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor

2011 ◽  
Vol 53 (2) ◽  
pp. 213-217 ◽  
Author(s):  
Jahanshah Salehinejad ◽  
Reza Zare-Mahmoodabadi ◽  
Shadi Saghafi ◽  
Amir-Hossien Jafarian ◽  
Narges Ghazi ◽  
...  
Keyword(s):  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Immunohistochemical Detection

ADENOMATOID ODONTOGENIC TUMOR: A CASE REPORT WITH EMPHASIS ON HISTOPATHOLOGIC FEATURES

2020 ◽  
Vol 129 (1) ◽  
pp. e66
Author(s):  
FERNANDA ARAGÃO FELIX ◽  
RODRIGO PORPINO MAFRA ◽  
LARISSA SANTOS AMARAL ROLIM ◽  
HELLEN BANDEIRA DE PONTES SANTOS ◽  
PATRÍCIA DAVIN GOMES PARENTE ◽  
...  
Keyword(s):  
Case Report ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Histopathologic Features

scholarly journals An unusually large aggressive adenomatoid odontogenic tumor of maxilla involving the third molar: A clinical case report

2016 ◽  
Vol 10 (02) ◽  
pp. 277-280 ◽  
Author(s):  
Vikas Dhupar ◽  
Francis Akkara ◽  
Pulkit Khandelwal
Keyword(s):  
Rare Case ◽  
Third Molar ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Impacted Tooth ◽  
The Third ◽  
Impacted Third Molar ◽  
Simultaneous Reconstruction ◽  
Odontogenic Lesion ◽  
Temporalis Myofascial Flap

ABSTRACTAdenomatoid odontogenic tumor (AOT) is a rare tumor comprising only 3% of all odontogenic tumors. It is a benign, encapsulated, noninvasive, nonaggressive, slowly growing odontogenic lesion associated with an impacted tooth. These lesions may go unnoticed for years. The usual treatment is enucleation and curettage, and the lesion does not recur. Here, we present a rare case of an unusually large aggressive AOT of maxilla associated with impacted third molar. The authors also discuss clinical, radiographic, histopathologic, and therapeutic features of the case. Subtotal maxillectomy with simultaneous reconstruction of the surgical defect with temporalis myofascial flap was planned and carried out.

Adenomatoid odontogenic tumor revisited

2017 ◽  
Vol 104 ◽  
pp. 35 ◽  
Author(s):  
Fumio Ide ◽  
Kentaro Kikuchi ◽  
Kaoru Kusama
Keyword(s):  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor
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