scholarly journals A RECENT UPDATE ON HISTOGENESIS OF ADENOMATOID ODONTOGENIC TUMOR: A REVIEW

2019 ◽  
pp. 55-62
Author(s):  
SAHANAZ P AHMED ◽  
NANDAKUMAR ARULMOZHI ◽  
RAMADAS RAMYA ◽  
KRISHNAKUMAR KARUNYA
Keyword(s):  
Odontogenic Tumor ◽  
Biological Behavior ◽  
Adenomatoid Odontogenic Tumor ◽  
Epithelial Tumor ◽  
Dental Lamina ◽  
Ultrastructural Studies ◽  
Root Sheath ◽  
Odontogenic Epithelium ◽  
Odontogenic Origin ◽  
Enamel Epithelium

Adenomatoid odontogenic tumor (AOT) is a relatively rare benign, epithelial tumor of odontogenic origin. There is varying class of thoughts contemplating this lesion to be a hamartoma or neoplastic growth of odontogenic epithelium. Controversy regarding the histogenesis of the lesion is plentiful in earlier literature. The recent advent of immunohistochemical and ultrastructural studies has aided in throwing light on the tissue of origin of this tumor. This review aims at understanding the evolving concepts of histogenesis of AOT to better understand the biological behavior of the lesion. The review of AOT was carried out using PubMed and Google Scholar databases and 39 articles from the year 2001 to 2016 which contributed to the histogenesis of AOT were included for review. Since the origin of the cystic lining is similar to a reduced enamel epithelium and not the dental lamina, we propose the former to be the progenitor of AOT. Furthermore, we consider extra-follicular, as well as peripheral AOTs, originate from the remnants of Hertwig’s epithelial root sheath (epithelial rests of Malassez), which complies with the common histology for all these variants.

Jaw cysts and odontogenic tumours

2018 ◽  
Author(s):  
Max Robinson ◽  
Keith Hunter ◽  
Michael Pemberton ◽  
Philip Sloan
Keyword(s):  
Enamel Organ ◽  
Odontogenic Cysts ◽  
Epithelial Lining ◽  
Jaw Cysts ◽  
Dental Lamina ◽  
Odontogenic Tumours ◽  
Jaw Bones ◽  
Root Sheath ◽  
Odontogenic Origin ◽  
Enamel Epithelium

Odontogenic cysts and tumours arise from inclusion of tooth-forming epithelium and mesenchyme in the jaw bones during development. Cysts also arise from non-odontogenic epithelium trapped during fusions or from vestigial structures. In addition, bone cysts that can arise at other skeletal sites may also occur in the jaws. Odontogenic cysts and tumours may be classified according to their putative developmental origins and biology. The classification of jaw cysts is shown in Fig. 6.1. Odontomes are hamartomatous develop­mental lesions of the tooth-forming tissues. Odontogenic tumours are uncommon and are usually benign. Ameloblastoma is the most com­mon odontogenic tumour and is described in detail. The other odon­togenic tumours are rare and only the principal features are presented. Very rare congenital lesions of possible odontogenic origin are men­tioned in the final section. A cyst may be defined as pathological cavity lined by epithelium with fluid or semi-fluid contents. However, clinically, the term encompasses a broader range of benign fluid-filled lesions, some of which do not possess an epithelial lining. The preferred definition is, therefore, ‘a pathological cavity having fluid or semi-fluid contents that has not been created by the accumulation of pus’. Cysts are commonly encountered in clinical dentistry and are generally detected on radiographs or as expansions of the jaws. Most cysts have a radiolucent appearance and are well circumscribed, often with a corticated outline. At least 90% of jaw cysts are of odontogenic origin. The clinico-pathological features of jaw cysts are summarized in Table 6.1. The incidence of the four most common jaw cysts are provided in Table 6.2. The epithelial lining of odontogenic cysts originates from residues of the tooth-forming organ. • Epithelial rests of Serres are remnants of the dental lamina and are thought to give rise to the odontogenic keratocyst, lateral periodon­tal, and gingival cysts. • Reduced enamel epithelium is derived from the enamel organ and covers the fully formed crown of the unerupted tooth. The dentiger­ous (follicular) and eruption cysts originate from this tissue, as do the mandibular buccal and paradental cysts. • Epithelial rests of Malassez form by fragmentation of Hertwig’s epi­thelial root sheath that maps out the developing tooth root. Radicular cysts originate from these residues.

scholarly journals Adenomatoid Odontogenic Tumor – A Report of Two Cases with Histopathology Correlation

2011 ◽  
Vol 1 ◽  
pp. 64 ◽  
Author(s):  
Pavitra Baskaran ◽  
Satyaranjan Misra ◽  
M. Sathya Kumar ◽  
R. Mithra
Keyword(s):  
World Health Organisation ◽  
Young Female ◽  
Odontogenic Tumor ◽  
World Health ◽  
Adenomatoid Odontogenic Tumor ◽  
Odontogenic Epithelium ◽  
Odontogenic Origin ◽  
Progressive Growth ◽  
Current Article

Adenomatoid odontogenic tumor (AOT) is an uncommon, hamartomatous, benign, epithelial lesion of odontogenic origin that was first described by Driebaldt in 1907, as a pseudo-adenoameloblastoma. The current World Health Organisation (WHO) classification of odontogenic tumors defines AOT as being composed of the odontogenic epithelium in a variety of histoarchitectural patterns, embedded in mature connective tissue stroma, and characterized by slow, but progressive growth. The current article reports two cases with different presentations; first in a young female patient and the second in a middle-aged male patient. The importance of biopsy, which is the gold standard for diagnosis, and its use in planning of the treatment is discussed.

scholarly journals A rare case of massif Adenomatoid Odontogenic Tumor in the anterior region of mandible: Mimicking as dentigerous cyst

2015 ◽  
Vol 27 (3) ◽  
Author(s):  
Aris Munandar ◽  
Endang Syamsudin ◽  
Melita Sylvyana ◽  
Kiki Akhmad Rizki
Keyword(s):  
Dentigerous Cyst ◽  
Final Diagnosis ◽  
Odontogenic Tumor ◽  
Radiographic Examination ◽  
Adenomatoid Odontogenic Tumor ◽  
Impacted Tooth ◽  
Unusual Site ◽  
Radiographic Features ◽  
Odontogenic Epithelium ◽  
Anterior Mandible

Background. Adenomatoid Odontogenic Tumor (AOT) is a rare tumor of epithelial origin. AOT appears in three clinico-topographic variants: follicular, extrafollicular and peripheral. The AOT was predominantly found in the upper jaw, and rarely found in mandible, especially at anterior mandible. AOT is a tumor of odontogenic epithelium having duct like structures, which may be partly cystic, and in some cases the solid lesion may be present only as masses in the wall of a large cyst. The surgical management of this lesion would be enucleation along with removal of associated impacted tooth. The prognosis for both of them is good and recurrences are very rare after complete removal of the lesion. Purpose. It is important to define final diagnose for AOT due to mimicking with DC in clinically and radiographically finding. Biopsy is still obviously necessary to the final diagnosis. Case. 15-year-old female patients reported with chief complain of swelling in anterior mandible. The swelling beginning 4 years ago, gradually progressed, with no history pain, discharge and patient is complaint about loss of sensation around anterior mandible. Aspiration revealed straw colored fluid thinking in the way of DC. The provisional diagnosis of DC was given due to clinical presentation and radiographic imaging. But the biopsy examination showed AOT due to duct-like epithelial cells was being found. Discussion. The case report illustrates characteristic clinical and radiographic features of follicular variant of AOT mimicking a DC at unusual site that is anterior mandible. AOT is thought to arise from odontogenic epithelium and associated with the impacted tooth. Rightfully AOT is a perfect imitator of DC radiographically as well as histopathologically. It usually clinically misdiagnosed as DC as both have a unilocular, well-defined radiolucency surrounding the crown of an impacted tooth. The mass was enucleated, involved teeth were extracted, and titanium plates are used to avoid pathologist fracture. The patient had uneventful postoperative recovery. Follow up of a year has not shown any evidence of recurrence. Conclusion. Follicular type of OAT could confuse us with DC if the support examination just only clinicaly finding and radiographic examination. This case could not be definitively diagnosed on clinical and radiographic features alone. Biopsy was obviously necessary to the final diagnosis.

scholarly journals Extrafollicular Adenomatoid Odontogenic Tumor of the Mandible: Report of a Case

2009 ◽  
Vol 03 (01) ◽  
pp. 71-74 ◽  
Author(s):  
Nergiz Yilmaz ◽  
Aydan Acikgoz ◽  
Nukhet Celebi ◽  
A. Zeynep Zengin ◽  
Omer Gunhan
Keyword(s):  
Computer Tomography ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Odontogenic Tumor ◽  
Anterior Region ◽  
Adenomatoid Odontogenic Tumor ◽  
Fine Needle ◽  
Odontogenic Origin

ABSTRACTThe purpose of this study was to report an extrafollicular adenomatoid odontogenic tumor in the mandibular anterior region in a patient. A 15 year-old female with a painless swelling in the mandibular anterior region was referred to our clinic. Fine needle aspiration yielded no fluid. Periapical, panoramic and computer tomography scans showed circumscribed radiolucent area with fine calcifications. The lesion was totally enucleated and the teeth 31, 32 were removed. The rarity of adenomatoid odontogenic tumor may be associated with its slowly growing pattern and symptomless behavior. Therefore, it should be distinguished from more common lesions of odontogenic origin in routine dental examinations. (Eur J Dent 2009;3:71-74)

scholarly journals Dentigerous Cyst or Adenomatoid Odontogenic Tumor: Clinical Radiological and Histopathological Dilemma

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Shivesh Acharya ◽  
Ashima Goyal ◽  
Vidya Rattan ◽  
Kim Vaiphei ◽  
Sarabjot Kaur Bhatia
Keyword(s):  
Complex System ◽  
Benign Tumor ◽  
Dentigerous Cyst ◽  
Common Variant ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Dental Lamina ◽  
Slow Growing

Adenomatoid odontogenic tumor (AOT) is a well-recognised slow growing benign tumor derived from complex system of dental lamina or its remnants. This lesion is categorised into three variants of which the more common variant is follicular type which is often mistaken for dentigerous cyst. We present a case of AOT in a 14-year-old male who was misdiagnosed as dentigerous cyst. Clinical radiological and therapeutic characteristics of the case are commented on in detail.

scholarly journals Adenoameloblastoma: A Dilemma in Diagnosis

2012 ◽  
Vol 13 (6) ◽  
pp. 925-929 ◽  
Author(s):  
Uma Shankar ◽  
A Radhika ◽  
Afshan Laheji ◽  
S Sakharde ◽  
S Chidambaram ◽  
...  
Keyword(s):  
Male Patient ◽  
Microscopic Examination ◽  
Rare Case ◽  
Dentigerous Cyst ◽  
Odontogenic Tumor ◽  
Anterior Region ◽  
Adenomatoid Odontogenic Tumor ◽  
Rare Finding ◽  
Odontogenic Origin ◽  
Epithelial Lesion

ABSTRACT Adenoameloblastoma or adenomatoid odontogenic tumor (AOT) is an uncommon, benign, epithelial lesion of odontogenic origin. It is a rare benign odontogenic tumor of the jaw affecting mostly young individuals with predominance in female. It occurs mostly in maxillary anterior region. On the basis of clinical and radiographical picture, it is often misdiagnosed as an odontogenic cyst. We report on a rare case of a 13-year-old male patient with a follicular variety of AOT in mandibular left anterior region which is unusual for the same. Clinically and radiographically, the lesion was mimicking as a dentigerous cyst. Later surgical enucleation was done and specimen was sent for microscopic examination and was diagnosed as AOT along with a dentinoid-like deposits which is a rare finding. How to cite this article Laheji A, Sakharde S, Chidambaram S, Gondhalekar RR, Shankar U, Radhika A. Adenoameloblastoma: A Dilemma in Diagnosis. J Contemp Dent Pract 2012;13(6): 925-929.

scholarly journals Cystic Adenomatoid Odontogenic Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Sonal Grover ◽  
Ahmed Mujib Bangalore Rahim ◽  
Nithin Kavassery Parakkat ◽  
Shekhar Kapoor ◽  
Kumud Mittal ◽  
...  
Keyword(s):  
Unusual Case ◽  
Dentigerous Cyst ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
New School ◽  
Cystic Component ◽  
Odontogenic Origin ◽  
Impacted Canine ◽  
The Difference ◽  
Epithelial Lesion

Adenomatoid Odontogenic Tumor (AOT) is a well-established benign epithelial lesion of odontogenic origin. Rightfully called “the master of disguise,” this lesion has been known for its varied clinical and histoarchitectural patterns. Not only does AOT predominantly present radiologically as a unilocular cystic lesion enclosing the unerupted tooth (which is commonly mistaken as a dentigerous cyst) but the lesion also presents rarely with a cystic component histopathologically. We present one such unusual case of cystic AOT associated with an impacted canine, mimicking a dentigerous cyst. The present case aims to highlight the difference between cystic AOT and dentigerous cyst radiographically. The exact histogenesis of AOT and its variants still remains obscure. An attempt has been made to hypothesize the new school of thought regarding the origin of AOT.

Adenomatoid Odontogenic Tumor – A Case Report

2019 ◽  
Vol 11 (1) ◽  
pp. 62-66
Author(s):  
Dr.Sahana Srinath
Keyword(s):  
Case Report ◽  
Female Patient ◽  
Benign Tumor ◽  
Case Reports ◽  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Canine Tooth ◽  
Odontogenic Origin ◽  
Impacted Canine ◽  
Uncommon Tumor

Adenomatoid odontogenic tumor, a benign tumor of odontogenic origin has known for many years. Only few case reports have been published in the literatute and hence considered to be an uncommon tumor. The lesion has been called by various names as it has exhibited in various clinical and histological patterns for which the origin and histogenesis still remains uncertain. Here, we report a case of 18 year old female patient who came to us with a complain of swelling in the upper anterior tooth region and radiographically showing an Extrafollicular radiolucency adjacent to the crown of an impacted canine tooth.

scholarly journals Adenomatoid odontogenic tumor - a rare cause of jaw swelling

2005 ◽  
Vol 16 (3) ◽  
pp. 251-253 ◽  
Author(s):  
Sonu Nigam ◽  
Sanjeev Kumar Gupta ◽  
K. Uma Chaturvedi
Keyword(s):  
Odontogenic Tumor ◽  
Adenomatoid Odontogenic Tumor ◽  
Review Of Literature ◽  
Follicular Variant ◽  
Tooth Resorption ◽  
Odontogenic Origin ◽  
Uncommon Tumor ◽  
True Neoplasm

Adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin, characterized histologically by the formation of ductlike structures with amyloid-like deposits. Histogenesis of AOT is still uncertain and it is often considered as a hamartomatous lesion rather than a true neoplasm. AOT has a benign behavior and conservative surgical enucleation or curettage is sufficient. We report a case of AOT in a 15-year-old female who presented with left-sided jaw swelling with tooth resorption. Histopathology revealed intraosseus follicular variant of AOT. A brief review of literature is also discussed.

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