scholarly journals Obesity hypoventilation syndrome: a current review

2018 ◽  
Vol 44 (6) ◽  
pp. 510-518 ◽  
Author(s):  
Rodolfo Augusto Bacelar de Athayde ◽  
José Ricardo Bandeira de Oliveira Filho ◽  
Geraldo Lorenzi Filho ◽  
Pedro Rodrigues Genta
Keyword(s):  
Positive Airway Pressure ◽  
High Morbidity ◽  
Obesity Hypoventilation Syndrome ◽  
Behavioral Measures ◽  
Current Review ◽  
High Prevalence ◽  
Hypoventilation Syndrome ◽  
Obesity Hypoventilation ◽  
A Current

ABSTRACT Obesity hypoventilation syndrome (OHS) is defined as the presence of obesity (body mass index ≥ 30 kg/m²) and daytime arterial hypercapnia (PaCO2 ≥ 45 mmHg) in the absence of other causes of hypoventilation. OHS is often overlooked and confused with other conditions associated with hypoventilation, particularly COPD. The recognition of OHS is important because of its high prevalence and the fact that, if left untreated, it is associated with high morbidity and mortality. In the present review, we address recent advances in the pathophysiology and management of OHS, the usefulness of determination of venous bicarbonate in screening for OHS, and diagnostic criteria for OHS that eliminate the need for polysomnography. In addition, we review advances in the treatment of OHS, including behavioral measures, and recent studies comparing the efficacy of continuous positive airway pressure with that of noninvasive ventilation.

scholarly journals Case report: fast reversal of malignant obesity hypoventilation syndrome after noninvasive ventilation and pulmonary rehabilitation

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Shengyu Hao ◽  
Lingling Pang ◽  
Liang Xie ◽  
Xu Wu ◽  
Zilong Liu ◽  
...  
Keyword(s):  
Noninvasive Ventilation ◽  
Pulmonary Rehabilitation ◽  
Good Condition ◽  
Program Improvement ◽  
Apnea Hypopnea Index ◽  
High Morbidity ◽  
Obesity Hypoventilation Syndrome ◽  
Extreme Obesity ◽  
Hypoventilation Syndrome ◽  
Obesity Hypoventilation

Abstract Background Malignant obesity hypoventilation syndrome (MOHS) is described as a subtype condition of OHS, characterized by extreme obesity, obese-related hypoventilation, and multiorgan dysfunction. Because of low awareness and inadequate treatment, MOHS leads to high morbidity and mortality. Case presentation A 53-year-old man was diagnosed with MOHS evidenced by extreme obesity and multiorgan abnormalities. After taken noninvasive ventilation (NIV) treatment, he was rescued. And at the end of the six-month pulmonary rehabilitation (PR) program, improvement in terms of respiratory parameters, BMI, apnea-hypopnea index (AHI), and pulmonary hypertension were observed in the patient. Two years later, the patient was still in good condition. Conclusions This case highlights the awareness and proper use of NIV to rescue MOHS patients. Furthermore, the benefits of PR were explored in this case, which has not been considered within the therapeutic options for MOHS patients.

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