Mechanisms of Calcium Signaling and Function in Lymphocytes

2006 ◽  
Vol 26 (2) ◽  
pp. 97-112 ◽  
Author(s):  
Bruce D. Freedman
Keyword(s):  
Calcium Signaling ◽  
And Function

3008 – OXYGEN TENSION REGULATES CALCIUM SIGNALING AND FUNCTION IN HEMATOPOIETIC STEM AND PROGENITOR CELLS

2020 ◽  
Vol 88 ◽  
pp. S40
Author(s):  
Paige Dausinas ◽  
Jacob Slack ◽  
Christopher Basile ◽  
Anish Karlapudi ◽  
Heather O'Leary
Keyword(s):  
Calcium Signaling ◽  
Progenitor Cells ◽  
Oxygen Tension ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells ◽  
And Function

Calcium signaling in the development and function of T-lineage cells

2009 ◽  
Vol 231 (1) ◽  
pp. 210-224 ◽  
Author(s):  
Masatsugu Oh-hora
Keyword(s):  
Calcium Signaling ◽  
And Function

scholarly journals Early mitochondrial stress and metabolic imbalance lead to photoreceptor cell death in retinal degeneration

2021 ◽  
Author(s):  
Ke Jiang ◽  
Anupam K Mondal ◽  
Yogita Adlakha ◽  
Jessica Gumerson ◽  
Angel M Aponte ◽  
...  
Keyword(s):  
Cell Death ◽  
Calcium Signaling ◽  
Retinal Degeneration ◽  
Photoreceptor Cell ◽  
Ex Vivo ◽  
Transcriptome Profiling ◽  
Central Carbon Metabolism ◽  
Pentose Phosphate ◽  
Mitochondrial Stress ◽  
And Function

Neurodegenerative diseases exhibit extensive genetic heterogeneity and complex etiology with varying onset and severity. To deduce the mechanism leading to retinal degeneration, we adopted a temporal multi-omics approach and examined molecular and cellular events before the onset of photoreceptor cell death in the widely-used Pde6brd1/rd1 (rd1) mouse model. Transcriptome profiling of neonatal and developing rods revealed early downregulation of genes associated with anabolic pathways and energy metabolism. Quantitative proteomics of rd1 retina showed early changes in calcium signaling and oxidative phosphorylation, with specific partial bypass of complex I electron transfer, which precede the onset of cell death. Concurrently, we detected alterations in central carbon metabolism, including dysregulation of components associated with glycolysis, pentose phosphate and purine biosynthesis. Ex vivo assays of oxygen consumption and transmission electron microscopy validated early and progressive mitochondrial stress and abnormalities in mitochondrial structure and function of rd1 rods. These data uncover mitochondrial over-activation and related metabolic alterations as early determinants of pathology and implicate dysregulation of calcium signaling as the initiator of higher mitochondrial stress, which then transitions to mitochondrial damage and photoreceptor cell death in retinal degeneration. Our studies support the one hit model arguing against the cumulative damage hypothesis but suggest that cell death in neurodegenerative disease is initiated by specific rather than a random event.

Structure and function of the CBL–CIPK Ca2+-decoding system in plant calcium signaling

2013 ◽  
Vol 31 (6) ◽  
pp. 1193-1202 ◽  
Author(s):  
Shan Zhu ◽  
Xiaoping Zhou ◽  
Xiaomei Wu ◽  
Zhonghao Jiang
Keyword(s):  
Calcium Signaling ◽  
Structure And Function ◽  
And Function

scholarly journals Modulation of T Cell Metabolism and Function through Calcium Signaling

2013 ◽  
Vol 4 ◽  
Author(s):  
Kelley M. Fracchia ◽  
Christine Y. Pai ◽  
Craig M. Walsh
Keyword(s):  
T Cell ◽  
Calcium Signaling ◽  
Cell Metabolism ◽  
And Function

Mechanisms and function of intercellular calcium signaling

1994 ◽  
Vol 98 (2) ◽  
pp. 173-187 ◽  
Author(s):  
Michael J. Sanderson ◽  
Andrew C. Charles ◽  
Scott Boitano ◽  
Ellen R. Dirksen
Keyword(s):  
Calcium Signaling ◽  
And Function

scholarly journals Cellular and nuclear morphology…and calcium signaling: revealing the interplay between structure and function

2012 ◽  
Vol 13 (S1) ◽  
Author(s):  
Markus Breit ◽  
Peter Bengtson ◽  
Anna Hagenston ◽  
Hilmar Bading ◽  
Gillian Queisser
Keyword(s):  
Calcium Signaling ◽  
Structure And Function ◽  
Nuclear Morphology ◽  
And Function
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