The PI3K p110δ controls T-cell development, differentiation and regulation

2007 ◽  
Vol 35 (2) ◽  
pp. 167-171 ◽  
Author(s):  
D.T. Patton ◽  
F. Garçon ◽  
K. Okkenhaug
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Development ◽  
Cell Development ◽  
Helper T Cells ◽  
Cellular Functions ◽  
Cellular And Humoral Immunity ◽  
And Migration ◽  
And Function

PI3Ks (phosphoinositide 3-kinases) regulate diverse cellular functions such as metabolism, growth, gene expression and migration. The p110δ isoform of PI3K is mainly expressed in cells of the immune system and contributes to cellular and humoral immunity. In the thymus, p110δ and p110γ play complementary roles in regulating the transition through key developmental checkpoints. In addition, p110δ regulates the differentiation of peripheral Th (helper T-cells) towards the Th1 and Th2 lineages. Moreover, p110δ is critical for Treg (regulatory T-cell) function. Here, we review the role of PI3Ks in T-cell development and function.

The role of Tec family kinases in T cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 119-138 ◽  
Author(s):  
Julie A. Lucas ◽  
Andrew T. Miller ◽  
Luana O. Atherly ◽  
Leslie J. Berg
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

Role of Shc in T-cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 183-195 ◽  
Author(s):  
Li Zhang ◽  
Ulrike Lorenz ◽  
Kodi S. Ravichandran
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

Role of Itk in γδ T cell development and function

2008 ◽  
Vol 22 (S2) ◽  
pp. 410-410
Author(s):  
Catherine Chih‐tzu Yin ◽  
Martin Felices ◽  
Yoko Kosaka ◽  
Joonsoo Kang
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell ◽  
And Function

scholarly journals Differential role of SLP-76 domains in T cell development and function

2002 ◽  
Vol 99 (2) ◽  
pp. 884-889 ◽  
Author(s):  
L. Kumar ◽  
V. Pivniouk ◽  
M. A. de la Fuente ◽  
D. Laouini ◽  
R. S. Geha
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

scholarly journals Differential effects of growth hormone and prolactin on murine T cell development and function.

1993 ◽  
Vol 178 (1) ◽  
pp. 231-236 ◽  
Author(s):  
W J Murphy ◽  
S K Durum ◽  
D L Longo
Keyword(s):  
Growth Hormone ◽  
T Cells ◽  
T Cell ◽  
Cell Function ◽  
T Cell Development ◽  
Cell Development ◽  
Double Positive ◽  
Peripheral T Cells ◽  
And Function ◽  
Dwarf Mice

DW/J dwarf mice have a defect in their anterior pituitary and are deficient in growth hormone (GH) and prolactin (PRL). These mice have been demonstrated previously to have a deficiency in CD4/CD8 double-positive thymocytes, which could be corrected by treatment of these mice with recombinant human GH. Since PRL has been implicated in T cell function and human GH can interact with the PRL receptor, DW/J dwarf mice were treated with either ovine GH (ovGH) (20 micrograms/d) or ovine PRL (ovPRL) (20 micrograms/d). The ovine hormones can only bind their own specific receptors in the mouse. After several weeks of treatment, it was found that these two hormones produced markedly contrasting effects on T cells. Phenotypic analysis of the lymphoid organs was performed by flow cytometry and the functional capability of the peripheral T cells was assessed by immunizing the mice and determining the extent of antigen-specific proliferation of T cells obtained from the draining lymph nodes or by determining splenic mitogen responses. The results indicated that ovGH administration to dwarf mice resulted in significant increases in thymic cellularity yet had little effect on peripheral T cell responses. In contrast, the administration of ovPRL resulted in a further decrease in thymic cellularity when compared with untreated dwarf mice. No thymic effects of either ovGH or ovPRL administration were detected on the normal +/? counterparts. However, ovPRL administration resulted in a significant increase in the number and function of antigen-specific peripheral T cells in both immunized dwarf and +/? mice. The adjuvant effects of PRL occurred even though the mice also received complete Freund's adjuvant. These results suggest that neuroendocrine hormones may act in concert in T cell development. GH appears to promote thymocyte proliferation, while PRL appears to decrease thymus size and yet augment the number and function of antigen-specific T cells in the periphery.

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