Beyond Mendelian Genetics: Anticipatory Biomedical Ethics and Policy Implications for the Use of CRISPR Together with Gene Drive in Humans

2018 ◽  
Author(s):  
Michael Nestor ◽  
Richard Wilson
Keyword(s):  
Biomedical Ethics ◽  
Policy Implications ◽  
Gene Drive ◽  
Mendelian Genetics

scholarly journals Split-gene drive system provides flexible application for safe laboratory investigation and potential field deployment

2019 ◽  
Author(s):  
Víctor López Del Amo ◽  
Alena L. Bishop ◽  
Héctor M. Sánchez C. ◽  
Jared B. Bennett ◽  
Xuechun Feng ◽  
...  
Keyword(s):  
Mendelian Inheritance ◽  
Gene Drive ◽  
Island Conservation ◽  
Vector Borne Diseases ◽  
Split Gene ◽  
Mendelian Genetics ◽  
Vector Borne ◽  
Field Deployment ◽  
Flexible Application ◽  
Gene Drives

ABSTRACTCRISPR-based gene drives spread through populations bypassing the dictates of Mendelian genetics, offering a population-engineering tool for tackling vector-borne diseases, managing crop pests, and helping island conservation efforts; unfortunately, current technologies raise safety concerns for unintended gene propagation. Herein, we address this by splitting the two drive components, Cas9 and gRNAs, into separate alleles to form a novel trans-complementing split–gene-drive (tGD) and demonstrate its ability to promote super-Mendelian inheritance of the separate transgenes. This bi-component nature allows for individual transgene optimization and increases safety by restricting escape concerns to experimentation windows. We employ the tGD and a small– molecule-controlled version to investigate the biology of component inheritance and use our system to study the maternal effects on CRISPR inheritance, impaired homology on efficiency, and resistant allele formation. Lastly, mathematical modeling of tGD spread in a population shows potential advantages for improving current gene-drive technologies for field population modification.

Responses to nervous breakdowns in America over a 40-year period: Mental health policy implications.

2000 ◽  
Vol 55 (7) ◽  
pp. 740-749 ◽  
Author(s):  
Ralph Swindle ◽  
Kenneth Heller ◽  
Bernice Pescosolido ◽  
Saeko Kikuzawa
Keyword(s):  
Mental Health ◽  
Health Policy ◽  
Mental Health Policy ◽  
Policy Implications
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