Modulation of Na+, K+-ATPase Activity in the Medulla Oblongata Neurons Affects Hemodynamics in Spontaneously Hypertensive Rats

2013 ◽  
Vol 4 (2) ◽  
pp. 123-136
Author(s):  
Lyudmila N. Shapoval ◽  
Olga Dmytrenko ◽  
Galyna L. Vavilova ◽  
Lyudmila S. Pobegaylo ◽  
Lyubov G. Stepanenko ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Medulla Oblongata ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Elevated tyrosine hydroxylase mRNA levels in medulla oblongata of spontaneously hypertensive rats

1996 ◽  
Vol 36 (1) ◽  
pp. 197-199 ◽  
Author(s):  
Toshio Kumai ◽  
Masami Tanaka ◽  
Minoru Watanabe ◽  
Hironori Nakura ◽  
Tomonori Tateishi ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Medulla Oblongata ◽  
Spontaneously Hypertensive Rats ◽  
Mrna Levels ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Evidence for Increased In Vivo Na+/K+-Atpase Activity in Skeletal Muscle of Spontaneously Hypertensive Rats

1990 ◽  
Vol 78 (s22) ◽  
pp. 8P-8P ◽  
Author(s):  
PD Syme ◽  
RM Dixon ◽  
JK Aronson ◽  
DG Grahame-Smith ◽  
GK Radda
Keyword(s):  
Skeletal Muscle ◽  
Atpase Activity ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Decreased Density of α2-Adrenoceptors in Medulla Oblongata of Spontaneously Hypertensive Rats

1989 ◽  
Vol 13 (3) ◽  
pp. 440-446 ◽  
Author(s):  
Shizuo Yamada ◽  
Naoki Ashizawa ◽  
Koichi Nakayama ◽  
Takako Tomita ◽  
Eiichi Hayashi
Keyword(s):  
Medulla Oblongata ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Α2 Adrenoceptors

Cell Membrane Microviscosity and Ca2+-Mg2+-ATPase Activity do Not Contribute to Hypertension in the Spontaneously Hypertensive Rat Model

1993 ◽  
Vol 85 (5) ◽  
pp. 585-591 ◽  
Author(s):  
Robert I Norman ◽  
Navtej Achall
Keyword(s):  
Blood Pressure ◽  
Atpase Activity ◽  
Spontaneously Hypertensive Rats ◽  
Spontaneously Hypertensive Rat ◽  
Hypertensive Rats ◽  
Membrane Microviscosity ◽  
Spontaneously Hypertensive ◽  
Blood Pressures ◽  
Wistar Kyoto ◽  
Spontaneously Hypertensive Rat Model

1. The relationships between systolic blood pressure and altered erythrocyte Ca2+-Mg2+-ATPase activity and membrane microviscosity were assessed in membranes prepared from 20-week-old female Wistar-Kyoto normotensive and spontaneously hypertensive rats obtained from two different sources (Charles River and Harlan OLAC) and a second filial (F2) generation derived from a cross between Wistar-Kyoto rats and spontaneously hypertensive rats from one source (Charles River). 2. Spontaneously hypertensive rats from both sources had systolic blood pressures significantly higher than those of Wistar-Kyoto animals (P <0.05; 151 + 4 and 110 + 3 mmHg, Charles River; 155 + 4 and 122 + 4 mmHg, Harlan OLAC). The systolic blood pressures for the F2 rat population ranged between 73 and 168 mmHg. 3. Ca2+-Mg2+-ATPase activity was measured as ATP-dependent 45Ca2+ uptake into inside-out vesicles and microviscosity assessed by the measurement of polarization anisotropy of membrane incorporated fluorescent probes including 1,6-diphenyl-1,3,5-hexatriene, trimethylamino-1,6-diphenyl-1,3,5-hexatriene and a series of anthroyloxy fatty acids. 4. Contrary to previous studies, no relationship between adult systolic blood pressure and erythrocyte Ca2+-Mg2+-ATPase activity or general or localized membrane microviscosity was indicated by the comparison of spontaneously hypertensive and Wistar-Kyoto animals or in the analysis of the F2 rat population. 5. These results suggest that Ca2+-Mg2+-ATPase activity and membrane microviscosity are causally unrelated to hypertension in these animals. On the assumption that biophysical properties of the erythrocyte membrane reflect those of smooth muscle, our results suggest that membrane alteration does not play a significant role in the pathogenesis of hypertension in the spontaneously hypertensive rat model.

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