scholarly journals Circulating immune complex-like materials which bind to heat inactivated C1q interfere with the C1q solid phase assay for immune complexes.

1985 ◽  
Vol 146 (4) ◽  
pp. 449-456 ◽  
Author(s):  
KAZUO FUKUDA ◽  
JIN SEINO ◽  
YASUMICHI KINOSHITA ◽  
KATSUHIKO SUDO ◽  
IKUO HORIGOME ◽  
...  
1982 ◽  
Vol 68 (6) ◽  
pp. 469-472 ◽  
Author(s):  
Raffaele D'Amelio ◽  
Brian Cooke ◽  
John R. Hobbs

The sera from 34 patients with malignant melanoma at various clinical stages of the disease were examined for the presence of circulating immune complexes (CIC) by the C1q solid-phase assay. Their urine and serum samples had been previously examined for the presence of an urinary melanoma-specific protein (MSP) and the corresponding serum antibody. Low levels of CIC (only in the third stage of the disease) and no positive correlation with the presence of MSP were found. The discordance between our and other author's data stresses again the fact that the different laboratory methods for CIC evaluation reveal in a different way the various CIC populations occurring in several diseases.


1993 ◽  
Vol 16 (4) ◽  
pp. 280-289
Author(s):  
Tetsuya Tsuzuki ◽  
Naoto Kawamura ◽  
Kazutaka Murakami ◽  
Midori Hasegawa ◽  
Shiro Kawashima

1989 ◽  
Vol 117 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Aloke Mohimen ◽  
Tushar K. Maitra ◽  
Kamal N. Jalan ◽  
Soumen Mehra

1981 ◽  
Author(s):  
M W Hilgartner ◽  
R D Inman ◽  
C H Miller

Elevated levels of circulating immune complexes (CIC) have been reported in a significant proportion of hemophilia patients tested by Raji cell, Clq binding, and staphylococcal binding (SBA) methods. The clinical significance of these complexes is unclear, as is their relationship to transfused material. By SBA, we found elevated CIC levels (>10 ug/ml) in 90% of severe hemophiliacs and 75% of multiply-transfused controls, all more than 72 hours post-transfusion. This was in contrast to our previous finding elevated CIC in 50% of hemophiliacs and 29% of controls by Raji cell assay.Using the SBA, seven patients were tested at intervals after Factor VIII concentrate infusion. Five showed increased CIC levels. The peak level occurred after the Factor VIII clotting activity had peaked and was declining. Two subjects showed rapid clearance of the complexes, while the others remained elevated at 24 hours. Factor VIII-related antigen was detected in isolated complexes from 2 patients. Our previous finding of HBsAg in such complexes suggests heterogeneity and perhaps different clearance patterns.


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