scholarly journals Clinical Characteristics of Gastric Cancer in Patients with Familial Adenomatous Polyposis

2013 ◽  
Vol 229 (2) ◽  
pp. 143-146 ◽  
Author(s):  
Chikashi Shibata ◽  
Hitoshi Ogawa ◽  
Koh Miura ◽  
Takeshi Naitoh ◽  
Jun-ichiro Yamauchi ◽  
...  
Endoscopy ◽  
2020 ◽  
Author(s):  
Isabel Martin ◽  
Victorine H. Roos ◽  
Chukwuemeka Anele ◽  
Sarah-Jane Walton ◽  
Victoria Cuthill ◽  
...  

Abstract Background Patients with familial adenomatous polyposis (FAP) are at increased risk of developing gastric adenomas. There is limited understanding of their clinical course and no consensus on management. We reviewed the management of gastric adenomas in patients with FAP from two centers. Methods Patients with FAP and histologically confirmed gastric adenomas were identified between 1997 and 2018. Patient demographics, adenoma characteristics, and management/surveillance outcomes were collected. Results Of 726 patients with FAP, 104 (14 %; 49 female) were diagnosed with gastric adenomas at a median age of 47 years (range 19 – 80). The median size of gastric adenomas was 6 mm (range 1.5 – 50); 64 (62 %) patients had adenomas located distally to the incisura. Five patients (5 %) had gastric adenomas demonstrating high-grade dysplasia (HGD) on initial diagnosis, distributed equally within the stomach. The risk of HGD was associated with adenoma size (P = 0.04). Of adenomas > 20 mm, 33 % contained HGD. Two patients had gastric cancer at initial gastric adenoma diagnosis. A total of 63 patients (61 %) underwent endoscopic therapy for gastric adenomas. Complications occurred in three patients (5 %) and two (3 %) had recurrence, all following piecemeal resection of large (30 – 50 mm) lesions. Three patients were diagnosed with gastric cancer at median follow-up of 66 months (range 66 – 115) after initial diagnosis. Conclusions We observed gastric adenomas in 14 % of patients with FAP. Of these, 5 % contained HGD; risk of HGD correlated with adenoma size. Endoscopic resection was feasible, with few complications and low recurrence rates, but did not completely eliminate the cancer risk.


2017 ◽  
Vol 153 (2) ◽  
pp. 353-354 ◽  
Author(s):  
Gautam Mankaney ◽  
Carol A. Burke ◽  
Michael Cruise ◽  
James Church ◽  
Vaibhav Wadhwa ◽  
...  

2018 ◽  
Vol 19 (6) ◽  
pp. 1682 ◽  
Author(s):  
Mara Fornasarig ◽  
Raffaella Magris ◽  
Valli De Re ◽  
Ettore Bidoli ◽  
Vincenzo Canzonieri ◽  
...  

2004 ◽  
Vol 49 (2) ◽  
pp. 260-265 ◽  
Author(s):  
Shouji Shimoyama ◽  
Fumio Aoki ◽  
Masaki Kawahara ◽  
Naohisa Yahagi ◽  
Toru Motoi ◽  
...  

2021 ◽  
pp. 919-940

This chapter provides a list of eponymous terms and rare diseases. These include acanthosis nigricans, which is pigmentation of the axillary skin associated with breast or gastric cancer; Baker’s cyst, which is almost always associated with knee joint pathology such as arthritis or torn meniscus; and Cloquet’s (Callisen’s) hernia, which is a deep femoral hernia that cannot protrude from the saphenous opening as it lies deep to the femoral vessels. The chapter then deals with DeQuervain’s disease, encephalocele, and familial adenomatous polyposis (FAP). It also describes gamekeeper’s thumb, hereditary osteodystrophy, inspissated bile syndrome, Jansen’s disease, Kaposi’s sarcoma, and livedo reticularis. Finally, the chapter defines McMurray’s test, which is used to identify medial meniscal tears; nutcracker oesophagus, which is an alternative name for diffuse oesophageal spasm; and osteogenesis imperfecta, which is an inherited collagen disorder, resulting in fragile bones that fracture easily, blue sclera, deafness, and soft teeth.


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