scholarly journals Exam 1: Endoscopic Ultrasound Imaging Detection of Gastric Cancer in Familial Adenomatous Polyposis

2017 ◽  
Vol 153 (2) ◽  
pp. e14-e15
2017 ◽  
Vol 153 (2) ◽  
pp. 353-354 ◽  
Author(s):  
Gautam Mankaney ◽  
Carol A. Burke ◽  
Michael Cruise ◽  
James Church ◽  
Vaibhav Wadhwa ◽  
...  

Endoscopy ◽  
2020 ◽  
Author(s):  
Isabel Martin ◽  
Victorine H. Roos ◽  
Chukwuemeka Anele ◽  
Sarah-Jane Walton ◽  
Victoria Cuthill ◽  
...  

Abstract Background Patients with familial adenomatous polyposis (FAP) are at increased risk of developing gastric adenomas. There is limited understanding of their clinical course and no consensus on management. We reviewed the management of gastric adenomas in patients with FAP from two centers. Methods Patients with FAP and histologically confirmed gastric adenomas were identified between 1997 and 2018. Patient demographics, adenoma characteristics, and management/surveillance outcomes were collected. Results Of 726 patients with FAP, 104 (14 %; 49 female) were diagnosed with gastric adenomas at a median age of 47 years (range 19 – 80). The median size of gastric adenomas was 6 mm (range 1.5 – 50); 64 (62 %) patients had adenomas located distally to the incisura. Five patients (5 %) had gastric adenomas demonstrating high-grade dysplasia (HGD) on initial diagnosis, distributed equally within the stomach. The risk of HGD was associated with adenoma size (P = 0.04). Of adenomas > 20 mm, 33 % contained HGD. Two patients had gastric cancer at initial gastric adenoma diagnosis. A total of 63 patients (61 %) underwent endoscopic therapy for gastric adenomas. Complications occurred in three patients (5 %) and two (3 %) had recurrence, all following piecemeal resection of large (30 – 50 mm) lesions. Three patients were diagnosed with gastric cancer at median follow-up of 66 months (range 66 – 115) after initial diagnosis. Conclusions We observed gastric adenomas in 14 % of patients with FAP. Of these, 5 % contained HGD; risk of HGD correlated with adenoma size. Endoscopic resection was feasible, with few complications and low recurrence rates, but did not completely eliminate the cancer risk.


2013 ◽  
Vol 229 (2) ◽  
pp. 143-146 ◽  
Author(s):  
Chikashi Shibata ◽  
Hitoshi Ogawa ◽  
Koh Miura ◽  
Takeshi Naitoh ◽  
Jun-ichiro Yamauchi ◽  
...  

2018 ◽  
Vol 19 (6) ◽  
pp. 1682 ◽  
Author(s):  
Mara Fornasarig ◽  
Raffaella Magris ◽  
Valli De Re ◽  
Ettore Bidoli ◽  
Vincenzo Canzonieri ◽  
...  

2004 ◽  
Vol 49 (2) ◽  
pp. 260-265 ◽  
Author(s):  
Shouji Shimoyama ◽  
Fumio Aoki ◽  
Masaki Kawahara ◽  
Naohisa Yahagi ◽  
Toru Motoi ◽  
...  

2021 ◽  
pp. 919-940

This chapter provides a list of eponymous terms and rare diseases. These include acanthosis nigricans, which is pigmentation of the axillary skin associated with breast or gastric cancer; Baker’s cyst, which is almost always associated with knee joint pathology such as arthritis or torn meniscus; and Cloquet’s (Callisen’s) hernia, which is a deep femoral hernia that cannot protrude from the saphenous opening as it lies deep to the femoral vessels. The chapter then deals with DeQuervain’s disease, encephalocele, and familial adenomatous polyposis (FAP). It also describes gamekeeper’s thumb, hereditary osteodystrophy, inspissated bile syndrome, Jansen’s disease, Kaposi’s sarcoma, and livedo reticularis. Finally, the chapter defines McMurray’s test, which is used to identify medial meniscal tears; nutcracker oesophagus, which is an alternative name for diffuse oesophageal spasm; and osteogenesis imperfecta, which is an inherited collagen disorder, resulting in fragile bones that fracture easily, blue sclera, deafness, and soft teeth.


2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 535-535
Author(s):  
Tatsuhiro Ito ◽  
Moriya Iwaizumi ◽  
Hong Tao ◽  
Satoshi Osawa ◽  
Kiyotaka Kurachi ◽  
...  

535 Background: Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary colorectal tumor syndrome characterized by the formation of a number of adenomatous polyps throughout the entire colon. Clinically, a precise family history together with surveillance of the colon as well as extra-colonic organs for people at risk is important to prevent cancer progression because of an almost 100% lifetime risk of colorectal cancer if the colon is not removed. Although there are fascinating correlations between the location of the APC mutation and the clinical phenotype, none has reported about genotype-phenotype correlation of gastric cancer in FAP, which occupies 2.1-4.2% in East Asia. Methods: Peripheral blood samples were obtained from 29 probands that was clinically diagnosed with FAP and DNA was extracted from the peripheral blood. All the coding exons of APC and their boundary regions were amplified using PCR and were directly sequenced. For large deletion/insertion analysis, an MLPA was performed using MLPA kit (P043 APC, MRC-Holland). Using results from the APC mutation analysis, we examined correlation between location of APCgermline mutation and clinical phenotype including gastric cancer. Results: Among 16 probands (3 cases were severe FAP, 12 cases classical FAP, and one case attenuated FAP) that were identified APC germline mutation, correlation between density of colonic adenomatous polypsosis and distribution of the APC mutation donated the same tendency of previous report. Among the 16 probands, 11 had fundic gland polyposis (FGPs) of the stomach and three had gastric adenocarcinoma (one case with FGPs and others without FGPs). Interestingly, all the three cases did not have severe adenomatous polyposis of the colon and their APC mutations were distributed at the location that is reported to be correlated with attenuated FAP. Conclusions: Patients with gastric cancer in FAP clinically have a tendency of having non-severe adenomatous polyposis of the colon and their location of APC mutation may be correlated to the hot spot location of attenuated FAP, suggesting that patient with non-severe colonic adenomatous polyp should have upper GI screening for gastric cancer prevention.


Sign in / Sign up

Export Citation Format

Share Document