scholarly journals New insights into mullerian inhibiting substance and its mechanism of action

1998 ◽  
Vol 158 (1) ◽  
pp. 1-6 ◽  
Author(s):  
AH Lane ◽  
PK Donahoe
Keyword(s):  
Mechanism Of Action ◽  
Sexual Development ◽  
Cell Types ◽  
Signaling Cascade ◽  
Downstream Signaling ◽  
Müllerian Inhibiting Substance ◽  
Primary Function ◽  
Therapeutic Uses ◽  
Mullerian Inhibiting Substance

The primary function of MIS in mammals is to initiate regression of Mullerian structures in males as part of normal sexual development. As we learn more about its other roles, particularly its influence on the growth and differentiation of cell types within the gonad, a more thorough understanding of the receptors that MIS stimulates and the downstream signaling cascade with which it interacts will help in the development of diagnostic and therapeutic uses of MIS.

Müllerian-inhibiting substance function during mammalian sexual development

Cell ◽  
1994 ◽  
Vol 79 (3) ◽  
pp. 415-425 ◽  
Author(s):  
Richard R. Behringer ◽  
Milton J. Finegold ◽  
Richard L. Cate
Keyword(s):  
Sexual Development ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Mechanism of Action of Mullerian Inhibiting Substance

1984 ◽  
Vol 46 (1) ◽  
pp. 53-65 ◽  
Author(s):  
P K Donahoe ◽  
J M Hutson ◽  
M E Fallat ◽  
S Kamagata ◽  
G P Budzik
Keyword(s):  
Mechanism Of Action ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substance

Nature ◽  
1990 ◽  
Vol 345 (6271) ◽  
pp. 167-170 ◽  
Author(s):  
Richard R. Behringer ◽  
Richard L. Cate ◽  
Glenda J. Froelick ◽  
Richard D. Palmiter ◽  
Ralph L. Brinster
Keyword(s):  
Transgenic Mice ◽  
Sexual Development ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Müllerian Inhibiting Substance: Gene Structure and Mechanism of Action of a Fetal Regressor

1987 ◽  
pp. 431-467
Author(s):  
PATRICIA K. DONAHOE ◽  
RICHARD L. CATE ◽  
DAVID T. MACLAUGHLIN ◽  
JAMES EPSTEIN ◽  
ARLAN F. FULLER ◽  
...  
Keyword(s):  
Gene Structure ◽  
Mechanism Of Action ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Gubernacular development in Müllerian inhibiting substance receptor-deficient mice

2002 ◽  
Vol 89 (1) ◽  
pp. 113-118 ◽  
Author(s):  
J.E. Bartlett ◽  
S.M.Y. Lee ◽  
Y. Mishina ◽  
R.R. Behringer ◽  
N. Yang ◽  
...  
Keyword(s):  
Müllerian Inhibiting Substance ◽  
Deficient Mice ◽  
Mullerian Inhibiting Substance

scholarly journals Photocontrolled apoptosis induction using precursor miR-664a and an RNA carrier-conjugated with photosensitizer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kazunori Watanabe ◽  
Tomoko Nawachi ◽  
Ruriko Okutani ◽  
Takashi Ohtsuki
Keyword(s):  
Cancer Therapy ◽  
Cell Types ◽  
Drug Candidate ◽  
Apoptosis Induction ◽  
Delivery Method ◽  
Apoptotic Pathway ◽  
Photochemical Internalization ◽  
Therapeutic Uses ◽  
Induction Of Apoptosis ◽  
Nucleic Acid Drug

AbstractMethods to spatially induce apoptosis are useful for cancer therapy. To control the induction of apoptosis, methods using light, such as photochemical internalization (PCI), have been developed. We hypothesized that photoinduced delivery of microRNAs (miRNAs) that regulate apoptosis could spatially induce apoptosis. In this study, we identified pre-miR-664a as a novel apoptosis-inducing miRNA via mitochondrial apoptotic pathway. Further, we demonstrated the utility of photoinduced cytosolic dispersion of RNA (PCDR), which is an intracellular RNA delivery method based on PCI. Indeed, apoptosis is spatially regulated by pre-miR-664a and PCDR. In addition, we found that apoptosis induced by pre-miR-664a delivered by PCDR was more rapid than that by lipofection. These results suggest that pre-miR-664a is a nucleic acid drug candidate for cancer therapy and PCDR and pre-miR-664a-based strategies have potential therapeutic uses for diseases affecting various cell types.

Sign in / Sign up

Export Citation Format

Share Document