Mullerian Inhibiting Substance: Studies on its Mechanism of Action and Activity as an Anti-Tumor Agent

1989 ◽  
pp. 85-95
Author(s):  
David T. MacLaughlin ◽  
James Epstein ◽  
Patricia K. Donahoe
Keyword(s):  
Mechanism Of Action ◽  
Müllerian Inhibiting Substance ◽  
Tumor Agent ◽  
Mullerian Inhibiting Substance

scholarly journals New insights into mullerian inhibiting substance and its mechanism of action

1998 ◽  
Vol 158 (1) ◽  
pp. 1-6 ◽  
Author(s):  
AH Lane ◽  
PK Donahoe
Keyword(s):  
Mechanism Of Action ◽  
Sexual Development ◽  
Cell Types ◽  
Signaling Cascade ◽  
Downstream Signaling ◽  
Müllerian Inhibiting Substance ◽  
Primary Function ◽  
Therapeutic Uses ◽  
Mullerian Inhibiting Substance

The primary function of MIS in mammals is to initiate regression of Mullerian structures in males as part of normal sexual development. As we learn more about its other roles, particularly its influence on the growth and differentiation of cell types within the gonad, a more thorough understanding of the receptors that MIS stimulates and the downstream signaling cascade with which it interacts will help in the development of diagnostic and therapeutic uses of MIS.

Mechanism of Action of Mullerian Inhibiting Substance

1984 ◽  
Vol 46 (1) ◽  
pp. 53-65 ◽  
Author(s):  
P K Donahoe ◽  
J M Hutson ◽  
M E Fallat ◽  
S Kamagata ◽  
G P Budzik
Keyword(s):  
Mechanism Of Action ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Müllerian Inhibiting Substance: Gene Structure and Mechanism of Action of a Fetal Regressor

1987 ◽  
pp. 431-467
Author(s):  
PATRICIA K. DONAHOE ◽  
RICHARD L. CATE ◽  
DAVID T. MACLAUGHLIN ◽  
JAMES EPSTEIN ◽  
ARLAN F. FULLER ◽  
...  
Keyword(s):  
Gene Structure ◽  
Mechanism Of Action ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Gubernacular development in Müllerian inhibiting substance receptor-deficient mice

2002 ◽  
Vol 89 (1) ◽  
pp. 113-118 ◽  
Author(s):  
J.E. Bartlett ◽  
S.M.Y. Lee ◽  
Y. Mishina ◽  
R.R. Behringer ◽  
N. Yang ◽  
...  
Keyword(s):  
Müllerian Inhibiting Substance ◽  
Deficient Mice ◽  
Mullerian Inhibiting Substance

Ferriman-Gallwey Scores, Serum Androgen and Mullerian Inhibiting Substance Levels in Hirstute Adolescent Girls

2012 ◽  
Vol 25 (5) ◽  
pp. 300-304 ◽  
Author(s):  
S.P. Hertweck ◽  
J.L. Yoost ◽  
M.E. McClure ◽  
Y. Siow ◽  
G.N. Brock ◽  
...  
Keyword(s):  
Adolescent Girls ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Cellular Localization of Mullerian Inhibiting Substance in the Developing Rat Ovary

Endocrinology ◽  
1989 ◽  
Vol 124 (2) ◽  
pp. 1000-1006 ◽  
Author(s):  
SHIGERU UENO ◽  
MASAHIKO TAKAHASHI ◽  
THOMAS F. MANGANARO ◽  
RICHARD C. RAGIN ◽  
PATRICIA K. DONAHOE
Keyword(s):  
Cellular Localization ◽  
Müllerian Inhibiting Substance ◽  
Rat Ovary ◽  
Developing Rat ◽  
Mullerian Inhibiting Substance

Müllerian-inhibiting substance function during mammalian sexual development

Cell ◽  
1994 ◽  
Vol 79 (3) ◽  
pp. 415-425 ◽  
Author(s):  
Richard R. Behringer ◽  
Milton J. Finegold ◽  
Richard L. Cate
Keyword(s):  
Sexual Development ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

Müllerian inhibiting substance: New perspectives and future directions

1993 ◽  
Vol 25 (2) ◽  
pp. 121-133 ◽  
Author(s):  
Elizabeth A. Catlin ◽  
David T. MacLaughlin ◽  
Patricia K. Donahoe
Keyword(s):  
Future Directions ◽  
Müllerian Inhibiting Substance ◽  
Mullerian Inhibiting Substance

scholarly journals Müllerian inhibiting substance contributes to sex-linked biases in the brain and behavior

2009 ◽  
Vol 106 (17) ◽  
pp. 7203-7208 ◽  
Author(s):  
Pei-Yu Wang ◽  
Anna Protheroe ◽  
Andrew N. Clarkson ◽  
Floriane Imhoff ◽  
Kyoko Koishi ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Reproductive Tract ◽  
Behavioral Traits ◽  
Spinal Motor Neurons ◽  
Müllerian Inhibiting Substance ◽  
Males And Females ◽  
Brain And Behavior ◽  
And Behavior ◽  
The Brain ◽  
Mullerian Inhibiting Substance

Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.

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