Early vagus nerve stimulator implantation as a main predictor of positive outcome in pediatric patients with epileptic encephalopathy

2021 ◽  
Vol 23 (4) ◽  
pp. 563-571
Author(s):  
Angelo Russo ◽  
Ann Hyslop ◽  
Valentina Gentile ◽  
Antonella Boni ◽  
Ian Miller ◽  
...  
2012 ◽  
Vol 9 (4) ◽  
pp. 389-393 ◽  
Author(s):  
Aaron J. Clark ◽  
Rachel A. Kuperman ◽  
Kurtis I. Auguste ◽  
Peter P. Sun

Vagus nerve stimulation (VNS) is used as palliation for adult and pediatric patients with intractable epilepsy who are not candidates for curative resection. Although the treatment is generally safe, complications can occur intraoperatively, perioperatively, and in a delayed time frame. In the literature, there are 2 reports of pediatric patients with implanted VNS units who had refractory bradycardia that resolved after the stimulation was turned off. The authors report the case of a 13-year-old boy with a history of vagus nerve stimulator placement at 2 years of age, who developed intractable episodic bradycardia that persisted despite the cessation of VNS and whose imaging results suggested vagus nerve tethering by the leads. He was subsequently taken to the operating room for exploration, where it was confirmed that the stimulator lead was exerting traction on the vagus nerve, which was displaced from the carotid sheath. After the vagus nerve was untethered and the leads were replaced, the bradycardia eventually resolved with continual effective VNS therapy. When placing a VNS unit in a very young child, accommodations must be made for years of expected growth. Delayed intractable bradycardia can result from a vagus nerve under traction by tethered stimulator leads.


2021 ◽  
Vol 71 ◽  
pp. 110193
Author(s):  
Arthur Chyan ◽  
Sangeeta Kumaraswami ◽  
Suryanarayana Pothula

2016 ◽  
Vol 30 ◽  
pp. 83-87 ◽  
Author(s):  
Sandi Lam ◽  
Yimo Lin ◽  
Daniel J. Curry ◽  
Gaddum D. Reddy ◽  
Peter C. Warnke

2009 ◽  
Vol 41 (5) ◽  
pp. 383-387 ◽  
Author(s):  
Naoaki Tanaka ◽  
Elizabeth A. Thiele ◽  
Joseph R. Madsen ◽  
Blaise F. Bourgeois ◽  
Steven M. Stufflebeam

2016 ◽  
Vol 11 (2) ◽  
pp. 151 ◽  
Author(s):  
Hinaesh Upadhyay ◽  
Sushanth Bhat ◽  
Divya Gupta ◽  
Martha Mulvey ◽  
Sue Ming

2012 ◽  
Vol 10 (3) ◽  
pp. 226-229 ◽  
Author(s):  
Will P. Rodgers ◽  
Andrew J. Durnford ◽  
Fenella J. Kirkham ◽  
Andrea Whitney ◽  
Mark A. Mullee ◽  
...  

Object Interrater reliability as measured by the kappa (κ) statistic is a widely used and valuable tool to measure the robustness of a scoring system. Seizure frequency reduction is a central outcome measure following vagus nerve stimulation (VNS). A specific VNS scoring system has been proposed by McHugh, but its interrater reliability has not been tested. The authors assessed its interrater reliability and compared it with that of the Engel and International League Against Epilepsy (ILAE) systems. Methods Using the Engel, ILAE, and McHugh scoring systems, 3 observers independently rated the medical records of children who had undergone vagus nerve stimulator implantation between January 2001 and April 2011 at the Southampton University Hospital. The interrater agreements were then calculated using the κ statistic. Results Interrater reliability for the McHugh scale (κ0.693) was very good and was superior to those of the Engel (κ0.464) and ILAE (κ0.491) systems for assessing outcome in patients undergoing VNS. Conclusions The authors recommend considering the McHugh scoring system when assessing outcomes following VNS.


2022 ◽  
pp. 373-375
Author(s):  
John M. Stern ◽  
Noriko Salamon

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