Background: University students being energetic, active, and robust engage proactively in their lives. Students’ coping styles are important to deal with daily life issues. The current study investigated the mediating role of coping style between social support and psychological well-being among students of Karachi University, Pakistan. Method: To test the hypotheses, a sample of 105 university students (males 51 & females 55) with the age ranging between 19 to 36 years (mean age= 24.85; SD=.478) belonging to different socioeconomic status were selected from the University of Karachi, Pakistan. After taking permission from HOD of concerned departments, Demographic Information Form, Multidimensional Perceived Social Support Scale Coping styles scale, and Psychological Well-Being Scale were administered on participants in group settings. Descriptive statistics, correlation analysis, and Hayes’ PROCESS macro and bootstrap analysis were performed.Results: Problem-focused coping contributes 18 % variance in the psychological well-being of university students. Moreover, Social support brings 35 % and 46 % variation in the relationship of problem-focused coping; emotion-focused coping, and psychological well-being.Conclusion: Problem-focused coping was shown as an important mediating factor for social support and psychological wellbeing.