In present study, ionic profile of pharmaceutical drug molecule ferric pyrophosphate citrate by ion
exchange chromatography using conductivity detection was carried out. Ferric pyrophosphate citrate
is an iron organic complex used for hemodialysis for the chronic kidney disease patients. The drug is
used as iron supplementation to balance the iron loss during the dialysis for the kidney affected patients.
Anions, cation and metal ion were analyzed by ion chromatographic method. Relevant anions sulphate,
phosphate, citrate and pyrophosphate were analyzed by suppressed conductivity detection. Both isocratic
and gradient separation methods were developed for the anions analysis. Cation sodium was analyzed
by non-suppressed conductivity detection. Metal iron was determined by direct conductivity detection.
All the analyses were done covering selectivity, precision, linearity and accuracy aspects of analysis.
Calibration outcome of RSD 0.4 to 3.0% and correlation coefficient values greater than 0.999 were
observed during the studies. Spiking studies were done to check the accuracy of the analysis and the
recovery values ranging from 93 to 110% were observed. Around 90% ionic content of the drug
molecule can be characterized using the developed ion chromatographic methods. These methods can
be directly applied for the routine analysis of drug in the pharmaceutical industries.
Retrospective observational analysis of ferric pyrophosphate citrate (triferic®) administered via dialysate. Experience at a single facility over 2 years
