Antiphospholipid antibodies and combined pathology of small pelvis in women with tumors and tumoroid ovary formations, who suffer with infertility, and correction of revealed disorders

Histological Investigation ◽

Operative Laparoscopy

It is given in an article the obtained investigation results in studying antiphospholipid antibodies contains and combined pathology of small pelvis organs in 32 women with tumors and timorous ovary formations, who suffered with infertility. Analysis of anamnesis and clinic-laboratorial data, echography, operative laparoscopy and histological investigation is presented.

IgA Antiphospholipid Antibodies

10.1055/s-0037-1614467 ◽

1999 ◽

Vol 81 (02) ◽

pp. 319-320 ◽

Cited By ~ 3

Author(s):

Lynn Keil ◽

Hiroshi Eguchi ◽

Vincent DeBari

Keyword(s):

Antiphospholipid Antibodies

No Increase of β2-Glycoprotein I Levels in Patients with Antiphospholipid Antibodies

10.1055/s-0038-1646331 ◽

1992 ◽

Vol 68 (05) ◽

pp. 624-624 ◽

Cited By ~ 16

Author(s):

E De Benedetti ◽

G Reber ◽

P A Miescher ◽

P de Moerloose

Keyword(s):

Glycoprotein I

Antiphospholipid Antibodies: Prevalence, Clinical Significance and Correlation to Cytokine Levels in Acute Myeloid Leukemia and Non-Hodgkin’s Lymphoma

10.1055/s-0038-1649628 ◽

1993 ◽

Vol 70 (04) ◽

pp. 568-572 ◽

Cited By ~ 53

Author(s):

Roberto Stasi ◽

Elisa Stipa ◽

Mario Masi ◽

Felicia Oliva ◽

Alessandro Sciarra ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Clinical Significance ◽

Myeloid Leukemia ◽

Hodgkin’S Lymphoma ◽

Hodgkin's Lymphoma ◽

Tnf Alpha ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma ◽

Acute Myeloid

SummaryThis study was designed to explore the prevalence and clinical significance of elevated antiphospholipid antibodies (APA) titres in patients affected by acute myeloid leukemia (AML) and highgrade non-Hodgkin’s lymphoma (NHL). We also analyzed possible correlations with circulating levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and the soluble form of the receptor for interleukin-2 (sIL-2r). Nineteen patients with de novo AML and 14 patients with newly-diagnosed NHL were investigated. Tests for APA included the measurement of anticardiolipin antibodies (ACA) with a solid-phase immunoassay, and the detection of the lupus-like anticoagulant (LA) activity. Five patients with AML (26.3%) and 5 patients with NHL (35.7%) presented elevated APA at diagnosis, as compared to 3 of 174 persons of the control group (p <0.0001). APA titres became normal in all patients responding to treatment, whereas nonresponders retained elevated levels. In addition, 6 patients (4 with AML and 2 with NHL), who had normal APA at diagnosis and were either refractory to treatment or in relapse, subsequently developed LA and/or ACA positivity. At presentation, the mean levels of IgG- and IgM-ACA in patients were not significantly different from Controls, and concordance between ACA and LA results reached just 30%. With regard to the clinical course, we were not able to detect any statistically significant difference between patients with normal and elevated APA. Pretreatment concentrations of IL-6 and TNF-alpha in AML, and sIL-2r in NHL were found significantly elevated compared to Controls (p = 0.003, p = 0.009 and p = 0.024 respectively). In addition, the levels of these cytokines correlated with IgG-ACA at the different times of laboratory investigations. These results demonstrate that APA may have a role as markers of disease activity and progression in some haematological malignancies.

Antiphospholipid Antibodies, Recurrent Thromboembolism, and Intensity of Warfarin Anticoagulation

10.1055/s-0038-1650380 ◽

1996 ◽

Vol 75 (05) ◽

pp. 859-859 ◽

Cited By ~ 21

Author(s):

Paolo Prandoni ◽

Paolo Simioni ◽

Antonio Girolami

Keyword(s):

Antiphospholipid Antibodies

Autoantibodies to Phospholipids and to the Coagulation Proteins in AIDS

10.1055/s-0038-1656067 ◽

1997 ◽

Vol 77 (05) ◽

pp. 0856-0861 ◽

Cited By ~ 65

Author(s):

N Abuaf ◽

S Laperche ◽

B Rajoely ◽

R Carsique ◽

A Deschamps ◽

...

Keyword(s):

Lupus Erythematosus ◽

Blood Donors ◽

Heterogeneous Mixture ◽

Systemic Lupus ◽

Hematological Disorders ◽

False Positive Test ◽

Glycoprotein I ◽

Coagulation Proteins ◽

Hiv 1

SummaryIn HIV-1 infection, an increased prevalence of anticardiolipin autoantibodies (aCL) and lupus anticoagulant (LA) has been described. In order to see if these antibodies are isolated or, like in autoimmune diseases, associated with hematological disorders and with antibodies to other phospholipids and to proteins of coagulation, we investigated 3 groups of patients: 1. 342 HIV-1 infected patients, 2. 145 control patients including 61 systemic lupus erythematosus (SLE) patients, 58 patients with a connective tissue disease, 15 patients with stroke, 11 patients with syphilis and 3.100 blood donors. In HIV-1 infection antiprothrombin (aPrT) antibodies were present in 25% of patients, the prevalence of antiphosphatidylcholine antibodies (aPC) (50%) was almost as high as aCL (64%), and 39% had both antibodies. Absorption on liposomes of the latter revealed an heterogeneous mixture of aCL and aPC or cross-reacting antibodies. In contrast with SLE, anti-β2-glycoprotein I (4%), LA (1%), biological false positive test for syphilis (0.3%), thrombosis (p <0.001) were uncommon. In HIV-1 infection, antiphospholipid antibodies do not associate with features linked to them in SLE or syphilis.