Etiology of acute liver atrophy Mayer (Berlin, klirr Woch, 1921, № 31)

V. G.

doi:10.17816/kazmj79230

Etiology of acute liver atrophy Mayer (Berlin, klirr Woch, 1921, № 31)

Kazan medical journal ◽

10.17816/kazmj79230 ◽

2021 ◽

Vol 18 (3) ◽

pp. 105-105

Author(s):

V. G.

Keyword(s):

Liver Atrophy

Mayer (Berlin, klirr Woch, 1921, no. 31) emphasizes the important role that hies play in the etiology of acute atrophy of the liver: out of 25 cases of his material that were submitted for autopsy, in 15 cases of his material, the previous syphilis was undoubted and in 5 - probable.

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Liver atrophy following portacaval shunt in normal rats —a morphometric study—

Research in Experimental Medicine ◽

10.1007/bf01851384 ◽

1977 ◽

Vol 170 (2) ◽

pp. 133-142 ◽

Cited By ~ 13

Author(s):

E. Terlunen ◽

E. Altenähr ◽

K. Becker ◽

F. W. Ossenberg

Keyword(s):

Portacaval Shunt ◽

Morphometric Study ◽

Liver Atrophy

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Toxic cirrhosis resulting form Acute liver Atrophy

The American Journal of the Medical Sciences ◽

10.1097/00000441-192701000-00001 ◽

1927 ◽

Vol 173 (1) ◽

pp. 1-10 ◽

Cited By ~ 9

Author(s):

JOSEPH H. PRATT ◽

ALFRED STENGEL

Keyword(s):

Liver Atrophy

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Significant Improvement of Survival by Intrasplenic Hepatocyte Transplantation in Totally Hepatectomized Rats

Cell Transplantation ◽

10.1177/096368979600500303 ◽

1996 ◽

Vol 5 (3) ◽

pp. 369-378 ◽

Cited By ~ 14

Author(s):

Birgit A.P.M. Vogels ◽

Martinus A.W. Maas ◽

Anne Bosma ◽

Robert A.F.M. Chamuleau

Keyword(s):

Liver Failure ◽

Acute Liver Failure ◽

Survival Time ◽

Histological Examination ◽

Hepatocyte Transplantation ◽

Shunt Operation ◽

Blood Ammonia ◽

Liver Atrophy ◽

Arterial Blood ◽

Clinical Grading

The effect of intrasplenic hepatocyte transplantation (HTX) was studied in an experimental model of acute liver failure in rats with chronic liver atrophy. Rats underwent a portacaval shunt operation on Day -14 to induce liver atrophy, and underwent total hepatectomy on Day 0 as a start of acute liver failure. Intrasplenic hepatocyte or sham transplantation was performed on Day -7, -3, or -1 (n = 4 to 6 per group). During the period following hepatectomy, mean arterial blood pressure was maintained above 80 mm Hg and hypoglycaemia was prevented. Severity of hepatic encephalopathy was assessed by clinical grading and EEG spectral analysis, together with determination of blood ammonia and plasma amino acid concentrations, and “survival” time. Histological examination of the spleen and lungs was performed after sacrifice. Intrasplenic hepatocyte transplantation resulted in a significant improvement in clinical grading in all transplanted groups (p < 0.05), whereas a significant improvement in EEG left index was seen only in the group with transplantation on Day -1 (p < 0.05). In contrast to hepatocyte transplantation 1 day before total hepatectomy, rats with hepatocyte transplantation 3 and 7 days before total hepatectomy showed a significant 3- and 2-fold increase in “survival” time compared to sham transplanted controls: HTX at Day -1: 7.5 ± 0.3 h vs. 5.9 ± 0.6 h (p > 0.05), HTX at Day -3:19.7 ± 3.7 h vs. 6.5 ± 0.3 h (p < 0.05), and HTX at Day -7: 13.8 ± 3.2 h vs. 6.3 ± 0.3 h (p < 0.05). Furthermore, rats with hepatocyte transplantation on Day -3 and -7 showed significantly lower blood ammonia concentrations after total hepatectomy (p < 0.0001). Histological examination of the spleens after sacrifice showed clusters of hepatocytes in the red pulp. Hepatocytes present in the spleen for 3 and 7 days showed bile accumulation and spots of beginning necrosis. The present data show that in a hard model of complete liver failure in portacaval shunted rats, intrasplenic hepatocyte transplantation is able to prolong “survival” time significantly 2- to 3-fold. The relevance of this observation for human application is discussed.

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Liver atrophy and regeneration in noncirrhotic portal vein thrombosis: Effect of surgical shunts

Liver Transplantation ◽

10.1002/lt.25024 ◽

2018 ◽

Vol 24 (7) ◽

pp. 881-887 ◽

Cited By ~ 2

Author(s):

Abdulrhman S. Elnaggar ◽

Adam D. Griesemer ◽

Stuart Bentley-Hibbert ◽

Robert S. Brown ◽

Mercedes Martinez ◽

...

Keyword(s):

Portal Vein ◽

Portal Vein Thrombosis ◽

Liver Atrophy ◽

Vein Thrombosis

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Rapid liver atrophy and refractory ascites due to hepatoportal sclerosis in a patient after haploidentical stem cell transplantation

Leukemia & Lymphoma ◽

10.1080/10428194.2022.2027400 ◽

2022 ◽

pp. 1-4

Author(s):

Daisuke Ikeda ◽

Takafumi Tsushima ◽

Ami Fukumoto ◽

Ayumi Kuzume ◽

Rikako Tabata ◽

...

Keyword(s):

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Refractory Ascites ◽

Liver Atrophy ◽

Hepatoportal Sclerosis ◽

Haploidentical Stem Cell Transplantation

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Mirizzi syndrome associated with liver atrophy

Journal of Hepatology ◽

10.1016/s0168-8278(87)80087-9 ◽

1987 ◽

Vol 4 (2) ◽

pp. 245-249 ◽

Cited By ~ 6

Author(s):

Nicholas S. Hadjis ◽

Andrew Adam ◽

Gregory Hatzis ◽

Leslie H. Blumgart

Keyword(s):

Mirizzi Syndrome ◽

Liver Atrophy

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Comparison of the metabolic disturbances caused by end-to-side and side-to-side portacaval shunts

Journal of Applied Physiology ◽

10.1152/jappl.1996.80.3.885 ◽

1996 ◽

Vol 80 (3) ◽

pp. 885-891 ◽

Cited By ~ 10

Author(s):

P. A. Hawkins ◽

M. R. DeJoseph ◽

J. R. Vina ◽

R. A. Hawkins

Keyword(s):

Amino Acid Content ◽

Portacaval Shunt ◽

Glucose Consumption ◽

Fundamental Question ◽

Sham Operation ◽

Metabolic Disturbances ◽

Normal Pattern ◽

Liver Atrophy ◽

Portacaval Shunting ◽

At Will

Portacaval shunting causes liver atrophy, hyperammonemia, and hepatic encephalopathy. A fundamental question is whether the changes, especially those to brain, are permanent. To answer this, it is necessary to have a model whereby a portacaval shunt can be created for a period of time and then the normal pattern of circulation to the liver restored at will. An end-to-side shunt, the most extensively studied model of liver dysfunction, is permanent. However, a side-to-side shunt can be constructed that results in a somewhat different pattern of circulation but with the potential to be reversed. The purpose of the present study was to compare the severity of the metabolic disturbances caused by the two models. Rats with an end-to-side shunt, a side-to-side shunt, or sham operation were prepared and studied after 14-19 days. Both models of shunting caused the same degree of liver atrophy, hyperammonemia, and indistinguishable disturbances in the amino acid content of plasma and brain. Furthermore, both models produced the same degree of cerebral depression as measured by glucose consumption.

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