Research and Nursing Experience of Recombinant Human Epidermal Growth Factor Gel Promoting Oral Mucosal Erosion Lesion Healing

2021 ◽  
Vol 7 (5) ◽  
pp. 3905-3915
Author(s):  
Bo Yu ◽  
Bing Xu ◽  
Chonggui Qiu ◽  
Yang Liu

Erosion is a primary clinical manifestation of oral mucosal lesions. Contact between food and the mucosal surface during chewing can easily cause oral mucosal infection and adversely affect the daily lives of patients. Conventional clinical treatment cannot overcome the problems of oral mucosal erosion. This study aimed to analyze the application effect of recombinant human epidermal growth factor (rhEGF) gel on oral mucosal erosion lesions. The subjects of this study were 120 patients with oral mucosal erosion lesions, who were divided, according to random number table method, into a contrast group and rhEGF group with 60 cases in each. The patients in the contrast group were treated with ethacridine lactate, and the rhEGF group patients were treated with rhEGF gel. Patients in both groups received corresponding nursing measures. Compared with the contrast group, the rhEGF group had a lower visual analog scale score, Reticulation/keratosis, erythema, and ulceration score, and inflammatory cytokine levels, as well as a higher total effective rate and faster patient recovery, indicating that the rhEGF gel had significant efficacy and is worthy of promotion.

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e035802
Author(s):  
Qiancheng Hu ◽  
Xin Wang ◽  
Ye Chen ◽  
Xiaofen Li ◽  
Ting Luo ◽  
...  

IntroductionControversy regarding optimum duration of trastuzumab treatment remains in patients with human epidermal growth factor receptor-2 (HER2) positive early breast cancer. The objective of applying network meta-analysis (NMA) is to integrate existing evidence based on direct and indirect comparisons of efficacy and safety, and then to determine the duration of trastuzumab treatments with the greatest impact on therapeutic outcomes in HER2-positive early breast cancers.Methods and analysisElectronic searching of trastuzumab treatments for early breast cancer by titles and abstracts will be conducted for the period from inception to 16 June 2019 in PubMed, Cochrane Library, Embase and ClinicalTrils.gov, as well as the annual meetings of San Antonio Breast Cancer Symposium (SABCS), European Society of Medical Oncology (ESMO) and American Society of Clinical Oncology (ASCO) online archives. The outcomes of interest are overall survival, disease-free survival, acceptability, cardiotoxicities and grade 3 to 4 non-haematological toxicities. Two independent reviewers will screen and extract eligible data based on the inclusion and exclusion criteria, and then assess the risk of bias and evidence quality of individual studies using Cochrane Collaboration’s tool and Grades of Recommendation, Assessment, Development and Evaluation (GRADE). The heterogeneity, transitivity and inconsistency of NMA will be evaluated. In addition, we will perform subgroup and sensitivity analyses to assess the robustness and reliability of findings in our NMA.Ethics and disseminationEthics approval is not required for our NMA. Findings from our NMA will be submitted as peer-reviewed journal manuscripts and international conference reports.Trial registration numberCRD42019139109.


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