scholarly journals Understanding Process Performance Parameters in a Two-Step Monoclonal Antibody Chromatographic Purification Process

2016 ◽  
Author(s):  
Shaojie Zhang
Keyword(s):  
Monoclonal Antibody ◽  
Process Performance ◽  
Performance Parameters ◽  
Purification Process ◽  
Chromatographic Purification

A novel method for the non-chromatographic purification of technetium-99m-labeled monoclonal antibodies: a study with B72.3 monoclonal antibody

1994 ◽  
Vol 21 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Howard S. Rosenzweig ◽  
Girish N. Ranadive ◽  
Troy Seskey ◽  
Michael W. Epperly ◽  
William D. Bloomer
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Chromatographic Purification ◽  
Technetium 99M ◽  
Novel Method

scholarly journals Manipulation of the ATP pool as a tool for metabolic engineering

2015 ◽  
Vol 43 (6) ◽  
pp. 1140-1145 ◽  
Author(s):  
Oliver Hädicke ◽  
Steffen Klamt
Keyword(s):  
Metabolic Engineering ◽  
Product Yield ◽  
Volumetric Productivity ◽  
Special Focus ◽  
Process Performance ◽  
Performance Parameters ◽  
Cofactor Engineering ◽  
Atp Pool ◽  
Fine Tune

Cofactor engineering has been long identified as a valuable tool for metabolic engineering. Besides interventions targeting the pools of redox cofactors, many studies addressed the adenosine pools of microorganisms. In this mini-review, we discuss interventions that manipulate the availability of ATP with a special focus on ATP wasting strategies. We discuss the importance to fine-tune the ATP yield along a production pathway to balance process performance parameters like product yield and volumetric productivity.

Purification process development of a recombinant monoclonal antibody expressed in glycoengineered Pichia pastoris

2011 ◽  
Vol 76 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Youwei Jiang ◽  
Fang Li ◽  
Dongxing Zha ◽  
Thomas I. Potgieter ◽  
Teresa Mitchell ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Pichia Pastoris ◽  
Process Development ◽  
Purification Process ◽  
Recombinant Monoclonal Antibody

scholarly journals Recovery and purification process development for monoclonal antibody production

mAbs ◽  
2010 ◽  
Vol 2 (5) ◽  
pp. 480-499 ◽  
Author(s):  
Hui F. Liu ◽  
Junfen Ma ◽  
Charles Winter ◽  
Robert Bayer
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Production ◽  
Process Development ◽  
Purification Process ◽  
Monoclonal Antibody Production

Establishment of Operating Ranges in a Purification Process for a Monoclonal Antibody

1998 ◽  
pp. 80-92 ◽  
Author(s):  
Thomas M. Smith ◽  
Eileen Wilson ◽  
Robert G. Scott ◽  
John W. Misczak ◽  
John M. Bodek ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Purification Process

Impact of controlled ice nucleation on process performance and quality attributes of a lyophilized monoclonal antibody

2013 ◽  
Vol 450 (1-2) ◽  
pp. 70-78 ◽  
Author(s):  
David Awotwe-Otoo ◽  
Cyrus Agarabi ◽  
Erik K. Read ◽  
Scott Lute ◽  
Kurt A. Brorson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Quality Attributes ◽  
Ice Nucleation ◽  
Process Performance
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