scholarly journals Comparative study of anti-inflammatory property of calcium channel blocker and aspirin in albino rats

2018 ◽  
Vol 8 (1) ◽  
pp. 21
Author(s):  
Anjum Begum
Keyword(s):  
Inflammatory Response ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Control Group ◽  
Albino Rats ◽  
Standard Group ◽  
Channel Blockers ◽  
Treatment Of Hypertension ◽  
The Mean ◽  
Anti Inflammatory

Background: Calcium channel blockers are being used in the treatment of hypertension, ischemic heart disease, cardiac arrhythmias etc. They act by blocking the slow calcium channels. Influx of calcium is an essential step in the release of histamine and 5HT from mast cells and in the synthesis and release of prostaglandins. They are the main mediators in the process of inflammation. The aim of the present study was to compare anti-inflammatory properties of calcium channel blockers and aspirin in albino rats.Methods: Present study was prospective intervention study carried out to compare anti-inflammatory properties of calcium channel blockers and aspirin in albino rats. Total 30 albino rats were used, and they were divided into 5 groups of 6 each. First group of rats was control group where normal saline was used. Second group was standard group where aspirin was used. Remaining three groups were test groups and given nifedipine, amlodipine and diltiazem respectively. Effects were observed and compared between the groups.Results: In carrageenan method, the anti-inflammatory response of Aspirin was significantly higher. Nifedipine response was <aspirin but >diltiazem. The response of amlodipine was not significantly > that of control percent inhibition. In histamine method, the anti-inflammatory response of aspirin was significantly highest. Anti-inflammatory response of nifedipine was < aspirin but > diltiazem. Diltiazem response was < nifedipine but > amlodipine. In formaldehyde method, aspirin inhibition was highest at 96.2% followed by nifedipine (90.7%), diltiazem (75.9%) and amlodipine (3.7%). In cotton wool pellet granuloma, the mean dry granuloma weight was least for aspirin and percent anti-inflammatory activity was significantly high.Conclusions: Calcium channel blockers (nifedipine, diltiazem) have shown comparable anti-inflammatory property with that of aspirin. Further clinical studies are required for confirmation.

scholarly journals To evaluate the anti-inflammatory activity of ramipril in albino rats

2017 ◽  
Vol 7 (1) ◽  
pp. 16
Author(s):  
Siddamma Amoghimath ◽  
Suresha R. N. ◽  
Jayanthi M. K.
Keyword(s):  
Angiotensin Ii ◽  
Oxidant Stress ◽  
Inflammatory Activity ◽  
Control Group ◽  
Albino Rats ◽  
Standard Group ◽  
Paw Oedema ◽  
Cotton Pellet ◽  
The Mean ◽  
Anti Inflammatory

Background: Angiotensin II (Ang II) is a product of Renin angiotensin aldosterone system (RAAS). Angiotensin‑II regulates vascular tone, stimulates the release of pro‑inflammatory cytokines, activates nuclear factor‑kappa B (NF‑κB), increases oxidant stress and functions as an inflammatory molecule. Ramipril an ACE inhibitor act by inhibiting angiotensin converting enzyme, decreases angiotensinogen II activity. Hence the present was to evaluate the anti-inflammatory activity of Ramipril.Methods: Eighteen Wistar albino rats weighing around 150-200gms of either sex were randomly selected from central animal facility and divided into three groups. The control group received normal saline 25ml/kg, standard group received Indomethacin 10mg/kg and test group received Ramipril (0.9mg/kg) orally for six days. The animals were subjected to carrageenan induced paw oedema and cotton pellet induced granuloma model.Results: Ramipril significantly decreased the mean paw oedema in carrageenan induced paw oedema when compared to control and in cotton pellet induced granuloma Ramipril decreased the mean granuloma weight when compared to control.Conclusions: Ramipril showed anti-inflammatory activity when given for 6 consecutive days per orally in albino rats in carrageenan induced paw oedema and cotton pellet induced granuloma model.

Effect of Calcium-Channel Blockers on Cyclosporine Clearance and Use in Renal Transplant Patients

1994 ◽  
Vol 28 (11) ◽  
pp. 1227-1231 ◽  
Author(s):  
Ingrida S. Sketris ◽  
Michelle E. Methot ◽  
David Nicol ◽  
Philip Belitsky ◽  
Margot G. Knox
Keyword(s):  
Calcium Channel ◽  
Continuous Infusion ◽  
Calcium Channel Blockers ◽  
Graft Function ◽  
Control Group ◽  
Channel Blockers ◽  
Kidney Graft ◽  
Blood Concentrations ◽  
Significant Difference ◽  
The Mean

OBJECTIVE: To determine the effect of calcium-channel blockers (CCBs) on cyclosporine dose, clearance, and cost, and their effect on kidney graft function and survival in patients who underwent kidney transplant. DESIGN: A total of 176 adults receiving 177 transplants were studied retrospectively. Patients were stratified as follows: no CCB (n=57), diltiazem (n=13), nifedipine (n=37), and verapamil (n=70). Patients received cyclosporine 3–4 mg/kg by continuous infusion for 5 days followed by cyclosporine 10 mg/kg/d po to maintain initial whole blood concentrations of 300–400 ng/mL. Clearance of intravenously administered cyclosporine was calculated following at least 48 hours of the same dose by continuous infusion. The amount and cost of cyclosporine used during the first 10 days of oral therapy were also calculated. RESULTS: Patients receiving diltiazem, but not verapamil or nifedipine, had decreased clearance of intravenously administered cyclosporine compared with that of the mean control group. The mean clearance of intravenously administered cyclosporine ± SD in patients receiving no CCB was 5.1 ± 1.5 mL/min/kg, diltiazem was 3.7 ± 0.8 mL/min/kg, nifedipine was 6.4 ± 1.9 mL/min/kg, and verapamil was 5.2 ± 2.2 mL/min/kg. The amount and cost of 10 days of oral cyclosporine therapy was decreased in the verapamil group (5.7 ± 1.5 g and $257 ± 69) compared with that of the control group (6.7 ± 1.6 g and $304 ± 72) (p<0.001). There was no significant difference among the groups with respect to immediate graft function, 1-year serum creatinine concentration, or 1-year graft survival. CONCLUSIONS: Diltiazem decreased the clearance of intravenously administered cyclosporine. Although verapamil did not decrease the clearance of intravenously administered cyclosporine, it allowed a significant reduction in oral cyclosporine cost without apparent adverse effects on graft function. Further work is needed to determine the effect of CCBs on cyclosporine pharmacokinetics, especially with respect to their metabolism by gut and hepatic cytochrome P-450 enzymes, and their effect on patient outcome.

scholarly journals Impact of Calcium Channel Blockers on Aspirin Reactivity in Patients With Coronary Artery Disease

2021 ◽  
Author(s):  
Afek Kodesh ◽  
Eli Lev ◽  
Dorit Leshem-Lev ◽  
Alejandro Solodky ◽  
Ran Kornowski ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Platelet Reactivity ◽  
Aspirin Resistance ◽  
Control Group ◽  
Channel Blockers ◽  
Artery Disease ◽  
Stable Cad

Abstract Purpose: Calcium channel blockers (CCBs) do not reduce the risk of initial or recurrent myocardial infarction (MI) in patients diagnosed with stable coronary artery disease (CAD). The aim of this current study was to evaluate the association between CCBs and aspirin resistance in patients with CAD. Methods: Patients with stable CAD who were regularly taking aspirin (75-100 mg qd) for at least one month prior to enrollment in the study were included. The VerifyNow system was used for platelet function testing with high on-aspirin platelet reactivity (HAPR) defined as aspirin reaction units (ARU) >550. We compared patients treated with CCBs versus control group. Results: 503 patients with CAD were included in this study, 88 were treated with CCBs; Mean age (67.9±9.7 in the CCB group vs 66.5±11.4 in the control group, p=0.288), gender (77.3 male vs. 82.9%, p=0.214) and rates of diabetes mellitus (34.7 vs. 36.9%, p=.121) were similar. Rates of hypertension were higher in the CCB group (83.9 vs. 63.5%, p<0.01), but rates of past MI were lower (47.1 vs. 59.7%, p=0.039). The mean ARU was 465.4P70.0 for patients treated with CCBs versus 445.2u60.0 in controls (p=0.006). Similarly, 15.9% of CCB patients demonstrated HAPR compared to 7.0% (p=0.006). In a multivariate analysis, the administration of CCBs was independently associated with HAPR (OR- 1.72, 95% CI 1.04 – 8.91, p=0.047). Conclusions: Usage of CCBs is positively correlated with aspirin resistance. These findings may suggest an adverse pharmacologic effect of CCBs among patients with stable CAD treated with aspirin.

Calcium channel blockers and carcinogenesis in the elderly

1997 ◽  
Vol 78 (5) ◽  
pp. 398-399
Keyword(s):  
Medical Journal ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
The Elderly ◽  
Channel Blockers ◽  
Medical Institutions ◽  
Treatment Of Hypertension ◽  
The Usa

Lancet August 24, 1996 published an article by M. Pahor, J.M. Guralnick, L. Ferrucci, M.-C. Corti, M.E. Salive, J.R. Cerhan, R.B. Wallace, R.J. Havlik from different universities and medical institutions of Italy and the USA, where the problem of carcinogenesis risk as the result of widely used calcium channel blockers (CCBs) in treatment of hypertension is discussed. The editorial board of the Kazan Medical Journal, due to the importance of this problem, decided to introduce the main points of this article to its readers.

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