A study of surgical outcome of necrotizing pancreatitis

Background: Increasing understanding and literature regarding the management of Necrotizing Pancreatitis has laid paths for surgical and conservative management. Although a conservative approach is increasingly used, this study depicts the importance of surgical management in today’s era. The objective was to evaluate the surgical role in patients of documented Necrotizing Pancreatitis, with or without organ failure and debilitating symptoms by putting conservative management on a complementary part.Methods: Sixteen consecutive patients were reviewed with Necrotizing Pancreatitis managed at DVVPF’s Medical college and hospital, Ahmednagar between January 1, 2014, and July 1, 2017 documented by contrast-enhanced computed tomography (CECT).Results: Out of sixteen patients of Necrotizing Pancreatitis recruited for the study, 13 (81%) patients were surgically managed; among which death rate was 7%. Of the other 3(19%) patients which were conservatively managed, there was 1 (33%) death. Patient who died while conservative management would have been candidate for earlier surgical intervention.Conclusions: The results suggest that surgical approach can be applied successfully to manage most patients with Necrotizing Pancreatitis, still further evaluation being required for indication and timing of surgery.

Download Full-text

Dynamic contrast-enhanced computed tomography to assess early activity of cetuximab in squamous cell carcinoma of the head and neck

Radiology and Oncology ◽

10.2478/raon-2014-0030 ◽

2015 ◽

Vol 49 (1) ◽

pp. 17-25 ◽

Cited By ~ 7

Author(s):

Sandra Schmitz ◽

Denis Rommel ◽

Nicolas Michoux ◽

Renaud Lhommel ◽

François-Xavier Hanin ◽

...

Keyword(s):

Computed Tomography ◽

Squamous Cell Carcinoma ◽

The Other ◽

Time Points ◽

Dynamic Contrast Enhanced ◽

Contrast Enhanced ◽

Vascular Markers ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography ◽

Early Activity

Abstract Background. Cetuximab, a monoclonal antibody targeting the Epidermal Growth Factor Receptor (EGFR), has demonstrated activity in various tumor types. Using dynamic contrast-enhanced computed tomography (DCE-CT), we investigated the early activity of cetuximab monotherapy in previously untreated patients with squamous cell carcinoma of the head and neck (SCCHN). Methods. Treatment-naïve patients with SCCHN received cetuximab for 2 weeks before curative surgery. Treatment activity was evaluated by DCE-CT at baseline and before surgery. Tumor vascular and interstitial characteristics were evaluated using the Brix two-compartment kinetic model. Modifications of the perfusion parameters (blood flow Fp, extravascular space ve, vascular space vp, and transfer constant PS) were assessed between both time points. DCE data were compared to FDG-PET and histopathological examination obtained simultaneously. Plasmatic vascular markers were investigated at different time points. Results. Fourteen patients had evaluable DCE-CT parameters at both time points. A significant increase in the extravascular extracellular space ve accessible to the tracer was observed but no significant differences were found for the other kinetic parameters (Fp, vp or PS). Significant correlations were found between DCE parameters and the other two modalities. Plasmatic VEGF, PDGF-BB and IL-8 decreased as early as 2 hours after cetuximab infusion. Conclusions. Early activity of cetuximab on tumor interstitial characteristics was detected by DCE-CT. Modifications of plasmatic vascular markers are not sufficient to confirm anti-angiogenic cetuximab activity in vivo. Further investigation is warranted to determine to what extent DCE-CT parameters are modified and to evaluate whether they are able to predict treatment outcome.

Download Full-text

A Study of Neoplastic and Non-neoplastic Sinonasal Masses at a Tertiary Center

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1310 ◽

2017 ◽

Vol 10 (2) ◽

pp. 66-69

Author(s):

Kavita Sachdeva ◽

Saurav Naskar

Keyword(s):

X Ray ◽

Medical College ◽

Adenoid Cystic ◽

Neoplastic Lesion ◽

Contrast Enhanced ◽

Tertiary Center ◽

Neoplastic Lesions ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography ◽

Nasal Biopsy

ABSTRACT Aim The aim of this study was to evaluate all the cases of sinonasal masses based on histopathology into neoplastic and non-neoplastic lesions and to study their clinical and radiological presentations. Materials and methods The present study was carried out in 42 patients coming to the outpatient and inpatient Department of ENT of Netaji Subhash Chandra Bose Medical College & Hospital with the complaint of nasal obstruction during the period of March 2015 to August 2016. Patients were subjected to thorough clinical examinations and radiological investigations, which included digital X-ray paranasal sinus (PNS) and contrast-enhanced computed tomography PNS, and diagnosis was confirmed by nasal biopsy for histopathology reports. Results and observations A total of 42 patients were studied, of which 71.43% were non-neoplastic and 28.57% were neoplastic. Nasal polyps were the commonest non-neoplastic lesions (61.91%). Most common benign neoplastic lesion was angiofibroma (11.9%), while the commonest malignant neoplastic mass was found to be squamous cell carcinoma (7.14%). There was one case of adenoid cystic carcinoma. Conclusion Patients with sinonasal masses may present with trivial complaints, but proper evaluation of all the cases will enable us to make specific diagnosis and treat them accordingly. How to cite this article Sachdeva K, Naskar S. A Study of Neoplastic and Non-neoplastic Sinonasal Masses at a Tertiary Center. Clin Rhinol An Int J 2017;10(2):66-69.

Download Full-text

COMBINED USE OF ULTRASONOGRAPHY AND CONTRAST ENHANCED COMPUTED TOMOGRAPHY TO EVALUATE ACUTE NECROTIZING PANCREATITIS IN TWO DOGS

Veterinary Radiology & Ultrasound ◽

10.1111/j.1740-8261.2003.tb01453.x ◽

2003 ◽

Vol 44 (1) ◽

pp. 72-79 ◽

Cited By ~ 37

Author(s):

Jordan Q. Jaeger ◽

John S. Mattoon ◽

Shane W. Bateman ◽

Federica Morandi

Keyword(s):

Computed Tomography ◽

Necrotizing Pancreatitis ◽

Acute Necrotizing Pancreatitis ◽

Contrast Enhanced ◽

Combined Use ◽

Acute Necrotizing ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography

Download Full-text

Contrast-Enhanced Computed Tomography and Microangiography of the Pancreas in Acute Human Hemorrhagic/Necrotizing Pancreatitis

Pancreas ◽

10.1097/00006676-198802000-00010 ◽

1988 ◽

Vol 3 (1) ◽

pp. 53-60 ◽

Cited By ~ 31

Author(s):

Pekka Nuutinen ◽

Leena Kivisaari ◽

Tom Schröder

Keyword(s):

Computed Tomography ◽

Necrotizing Pancreatitis ◽

Contrast Enhanced ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography

Download Full-text

ROLE OF TRIPLE PHASE CONTRAST ENHANCED COMPUTED TOMOGRAPHY IN HEPATIC LESIONS AND THEIR CYTOPATHOLOGICAL CORRELATION

10.36106/ijar/1201308 ◽

2021 ◽

pp. 29-33

Author(s):

Sandeep Kaur ◽

Chaitanya Tapasvi ◽

Sarita Nibhoria ◽

Divya Soin

Keyword(s):

Computed Tomography ◽

Phase Contrast ◽

Imaging Modality ◽

Medical College ◽

Contrast Enhanced ◽

Highly Sensitive ◽

Hepatic Lesions ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography

AIMS: To evaluate the enhancement patterns of hepatic lesions on triple phase contrast enhanced computed tomography and to correlate the CT ndings of hepatic lesions with cytological ndings on ne needle aspiration cytology (FNAC). Settings and Design: This prospective observational study was carried out at Department of Radiodiagnosis, Gobind Singh Medical College and Hospital, Faridkot. The study was approved by the Institutional Ethics Committee. Source of Data: A total of 75 patients who had hepatic lesions on ultrasonography and clinical suspicion of focal hepatic lesions were referred for CECT abdomen. Findings of Triple phase CT for hepatic lesions were correlated with cytopathological ndings. Methods and Material: A Triphasic CECT abdomen was performed on Siemens Somatom Perspective 128 slice scanner in the Department of Radiodiagnosis, Guru Gobind Singh Medical College and Hospital, Faridkot. The entire liver was scanned successively, in arterial, portovenous and delayed phases. A 5mm collimation and 5mm/sec table speed were used. After obtaining a digital scout view, unenhanced scan of the liver was obtained.1.5ml/kg body weight of 300mgI/ml iodinated contrast material was administered by using a pressure injector at a rate of 3.0 mL/s using a pressure injector.USG/CT guided FNAC was done. CT imaging ndings were classied as benign or malignant by correlating them with cytopathological ndings. Results: The present study inferred that Triple phase CECT is a highly sensitive and specic imaging modality for detection and characterization of hepatic lesions with an overall sensitivity and specicity of 100.00 % (95% C.I. 92.45% to 100%) and 92.86% (95% C.I. 76.50% to 99.12%)respectively when correlated with cytopathological ndings. Conclusions: It is inferred from our study that triple phase CECT is highly sensitive and specic imaging modality for detection and characterization of hepatic lesions with wide availability in the present scenario.

Download Full-text

An unusual presentation of giant pancreatic pseudocyst in the parietal wall

Indian Journal of Case Reports ◽

10.32677/ijcr.v7i8.2993 ◽

2021 ◽

pp. 366-368

Author(s):

Ishita Laha ◽

Swapnil Sen ◽

Achintya Kumar Das

Keyword(s):

Pancreatic Pseudocyst ◽

Necrotizing Pancreatitis ◽

Fluid Collection ◽

Outlet Obstruction ◽

Exploratory Laparotomy ◽

Contrast Enhanced ◽

Acute Necrotizing ◽

True Cyst ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography

A true cyst is a localized fluid collection covered by a capsule lined by epithelium, whereas, a pseudocyst does not consist specific lining of cells. We report one such case of a 37-year-old gentleman with giant pancreatic pseudocyst in the anterior abdominal wall which had developed secondary to acute necrotizing pancreatitis. A contrast-enhanced computed tomography scan showed a pseudocyst in the lesser sac and left pre-renal fossa. He was planned for exploration but within a month, he was at the emergency with yet another episode of gastric outlet obstruction with a huge hypogastric swelling compressing the stomach. The patient was resuscitated and immediately posted for exploratory laparotomy. To the surprise of surgeons, the lump was just below the umbilicus with whatsoever no relation with the pancreas. However, the expert opinion of the histopathologists suggested it to be a pseudocyst.

Download Full-text