A rare case of Mucinous, tubular and spindle cell carcinoma of kidney and Histomorphological study of renal cell tumours

Abstract Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare renal cell carcinoma that initially presents as low-grade renal cell carcinoma. However, cases of MTSCC with high-grade histology and poor prognosis have been reported. Here, we report a case of MTSCC with high-grade histological features and metastasis. A 77-year-old woman consulted a hospital following frequent and painful micturition. Computed tomography scan revealed a tumor of the left kidney. First, chemotherapy was performed, with no effects. Therefore, nephrectomy was subsequently performed. Histologically, the tumor showed the features of MTSCC with sarcomatoid component. Metastasis of the tumor into the lymph node was also observed. Although adjuvant chemotherapy was performed after nephrectomy, metastasis to the lungs and bone and local recurrence was observed. The patient is still alive 2 years after nephrectomy with metastasis and recurrence of the tumor. High-grade MTSCC shows a relatively poor prognosis, specifically MTSCC with metastasis upon nephrectomy.

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Papillary renal cell carcinoma with low grade spindle cell foci, mimicking renal mucinous tubular and spindle cell carcinoma

Pathology ◽

10.1016/j.pathol.2017.11.029 ◽

2018 ◽

Vol 50 ◽

pp. S133

Author(s):

Tamara Welham ◽

Namita Mittal ◽

Genevieve Bennett ◽

Adrienne Morey

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Spindle Cell ◽

Papillary Renal Cell Carcinoma ◽

Spindle Cell Carcinoma ◽

Low Grade

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Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma

Case Reports in Pathology ◽

10.1155/2018/8734823 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Gang Wang ◽

Ren Yuan ◽

Tracy Tucker ◽

Allan B. Gates ◽

Christopher D. Bellamy ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Spindle Cell ◽

Neuroendocrine Differentiation ◽

Papillary Renal Cell Carcinoma ◽

Spindle Cell Carcinoma ◽

Unique Case ◽

Primary Neoplasm

A unique case of combined papillary renal cell carcinoma (PRCC) and mucinous tubular and spindle cell carcinoma (MTSCC) presenting in a man aged 67 years is reported. The two separate components were distinct on morphological, immunohistochemical (IHC), and genetic grounds, while type 2 PRCC predominated. Three years after the initial diagnosis, the PRCC component metastasized to the lungs where it morphologically mimicked a pulmonary neuroendocrine tumor. Retrospectively focal neuroendocrine differentiation was demonstrated by IHC in the PRCC component of the primary neoplasm.

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ALK Rearrangement-Associated Renal Cell Carcinoma Morphologically Mimicking Mucinous Tubular And Spindle Cell Carcinoma: A Case Report

10.21203/rs.3.rs-812298/v1 ◽

2021 ◽

Author(s):

Keita Kai ◽

Shohei Tobu ◽

Shinichi Kido ◽

Shuji Mikami ◽

Kengo Takeuchi ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Tumor Cells ◽

Renal Cell ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Renal Tumors ◽

Alk Rearrangement ◽

Anaplastic Lymphoma

Abstract Background: Anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC) is a very rare tumor and no single case report of ALK-RCC that mimics mucinous tubular and spindle cell carcinoma (MTSCC) has been reported.Case presentation: A 42-year-old Japanese woman was admitted to our hospital for the treatment of a left renal tumor measuring approximately 5 × 4 cm in diameter. She underwent a laparoscopic left nephrectomy. Histologically, the tumor formed tubular or focally papillary structures with a small amount of spindle-shaped tumor cells against the background of prominent extracellular mucin. Although the tumor cells were negative for immunohistochemistry (IHC) of alpha-methylacyl-CoA racemase (AMACR) and lymph node metastasis was presented (these are atypical findings for MTSCC), we initially diagnosed the tumor as MTSCC based on its morphological characteristics with mucin deposition. However, an additional IHC analysis revealed that the tumor cells were diffusely positive for ALK-IHC. In addition, TPM3 exon 8 – ALK exon 20 fusion gene was detected by RNA sequencing. The tumor was thus correctly diagnosed as ALK rearrangement-associated renal cell carcinoma (ALK-RCC). Conclusions: Since the use of molecular targeted therapy with an ALK inhibitor for ALK-RCC is promising, the correct pathological diagnosis of ALK-RCC is quite important. We strongly recommend that ALK-IHC be routinely performed for renal tumors with negative AMACR staining that mimic MTSCC.

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