scholarly journals Comparison of peripapillary and macular choroidal thickness and ganglion cell complex thickness in glaucomatous and healthy eyes

2019 ◽  
Vol 11 (4) ◽  
Keyword(s):  
Ganglion Cell ◽  
Choroidal Thickness ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Healthy Eyes

scholarly journals Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yiwei Wang ◽  
Chen Xin ◽  
Meng Li ◽  
David L. Swain ◽  
Kai Cao ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Case Series ◽  
Cell Complex ◽  
Vessel Density ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Percent Reduction ◽  
Healthy Eyes

Abstract Background To evaluate the macular vessel density (VD) and ganglion cell complex (GCC) thickness in pre-perimetric (PPG) and early perimetric primary open-angle glaucoma (PG) eyes, and to compare the diagnostic ability of the two measurements to discriminate PPG and early PG eyes from healthy eyes. Methods Seventy-nine eyes in 72 subjects (31 normal, 26 PPG, and 22 early PG eyes) were included in the consecutive case series. Macular VD and GCC thickness were acquired simultaneously using the 6 × 6 mm2 high-density AngioRetina scanning mode. Diagnostic abilities were assessed using the area under the receiver operating characteristic curve (AUROC). Results Compared to healthy eyes, whole image VD (wiVD) and GCC thickness were significantly lower in PPG and early PG eyes (all P < 0.025). The percent reduction of wiVD was lower than that of GCC thickness in early PG eyes (P < 0.05), while they were similar in PPG eyes (P > 0.05). Regionally, greater VD attenuation and GCC thinning were identified in the perifovea than in the parafovea in both groups (all P < 0.05). Moreover, the percent reduction of VD was less than that of GCC thickness in the perifoveal region in PPG eyes (P < 0.05). The AUROCs for wiVD and GCC thickness were 0.824 and 0.881, respectively, in PPG eyes (P > 0.05), and 0.918 and 0.977, respectively, in early PG eyes (P > 0.05). Conclusions Macular VD and GCC thickness significantly decreased in PPG and early PG eyes. The perifoveal region appeared to be more vulnerable to macular VD attenuation and GCC thinning in early glaucoma. Our results showed that macular VD measurements may be helpful for detecting and understanding early glaucomatous damage.

scholarly journals Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Joanna Gołębiewska ◽  
Andrzej Olechowski ◽  
Marta Wysocka-Mincewicz ◽  
Marta Baszyńska-Wilk ◽  
Artur Groszek ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Type 1 Diabetes ◽  
Ganglion Cell ◽  
Hba1c Level ◽  
Choroidal Thickness ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Significant Difference ◽  
Sd Oct

Aim. To assess the retinal and choroidal thickness and ganglion cell complex (GCC) in pubescent children with type 1 diabetes (T1D) without diabetic retinopathy (DR), using spectral domain optical coherence tomography (SD-OCT). Materials and Method. Sixty-four right eyes of 64 subjects with T1D and 45 right eyes of 45 age-matched healthy volunteers (control group) were enrolled in this study. The mean age of the subjects and controls was 15.3 (±SD = 2.2) and 14.6 (±SD = 1.5), respectively. SD-OCT was performed using RTVue XR Avanti. Ganglion cell complex (GCC), GCC focal loss volume (FLV), GCC global loss volume (GLV), choroidal thickness (CT), foveal (FT) and parafoveal thickness (PFT), and foveal (FV) and parafoveal volume (PFV) data were analyzed. Results. There was no significant difference between subjects and controls in the CT in the fovea and nasal, temporal, superior, and inferior quadrants of the macula. There were no significant correlations between CT, duration of diabetes, and HbA1C level (p=0.272 and p=0.197, resp.). GCC thickness did not differ significantly between the groups (p=0.448), but there was a significant difference in FLV (p=0.037). Significant differences between the groups were found in the PFT and PFV (p=0.004 and p=0.005, resp.). There was a significant negative correlation between PFT, PFV, and HbA1C level (p=0.002 and p=0.001, resp.). Conclusions. Choroidal thickness remains unchanged in children with T1D. Increased GCC FLV might suggest an early alteration in neuroretinal tissue. Parafoveal retinal thickness is decreased in pubescent T1D children and correlates with HbA1C level. OCT can be considered a part of noninvasive screening in children with T1D and a tool for early detection of retinal and choroidal abnormalities. Further OCT follow-up is needed to determine whether any of the discussed OCT measurements are predictive of future DR severity.

scholarly journals Choroidal thickness, ganglion cell complex and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography

2019 ◽  
Author(s):  
Selim Bolukbasi ◽  
Ozge Kandemir Gursel ◽  
Akin Cakir ◽  
Burak Erden ◽  
Gamze Karatas
Keyword(s):  
Ganglion Cell ◽  
Choroidal Thickness ◽  
Outer Segment ◽  
Tamoxifen Therapy ◽  
Cell Complex ◽  
Segment Length ◽  
Ganglion Cell Complex ◽  
Photoreceptor Outer Segment ◽  
Tamoxifen Group ◽  
Sd Oct

Abstract Background To evaluate choroidal thickness, ganglion cell complex and photoreceptor outer segment length in patients with breast cancer undergoing tamoxifen therapy using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes. Methods Fourty four patients with breast cancer undergoing tamoxifen therapy and fourty one healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500 μm, 1000 μm, 1500 μm) and temporal (temporal distance to fovea 500 μm, 1000 μm, 1500 μm) choroidal thickness measurements were performed using enhanced depth imaging mode of SD-OCT. Using an Early Treatment Diagnostic Retinopathy Study (ETDRS) circle at the macular level, the automated retinal segmentation software was applied to determine thicknesses of the ganglion cell complex (GCC) by adding the macular retinal nerve fiber layer, macular ganglion cell layer, and macular internal plexiform layer parameters. The photoreceptor outer segment (PROS) length was determined by manually as the distance from inner surface of ellipsoid zone to inner surface of retina pigment epithelium after automatic retinal segmentation. Results The mean choroidal thickness measurements were statistically greater in tamoxifen group than controls in all quadrants (p<0.001 for all quadrants). Of all tamoxifen users (44 eyes of 44 patients), 33 eyes (75%) had uncomplicated pachychoroid (UCP). Pachychoroid pigment epitheliopathy (PPE) was detected in 5 patients (11.3%) in tamoxifen group. Patients with PPE in one eye had UCP in the fellow eye. Central serous chorioretinopathy findings were observed in one patient. Tamoxifen users had statistically lower GCC thicknesses in all inner rings of ETDRS inlay and only in nasal outer ring (p:0.027, p:0.002, p:0.002, p:0.001 and p:0.030; respectively). No statistically significant difference was found between the groups in terms of mean subfoveal PROS length. Conclusions SD-OCT provides valuable information in identifying the structural changes and evaluation of ocular findings in patients receiving tamoxifen therapy. Increasing choroidal thickness, PPE, thinning GCC were detected in tamoxifen users. These OCT findings may be an early indicator of retinal toxicity for patients undergoing tamoxifen therapy in follow-up period.

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