Asle Eikrem: God as Sacrificial Love: A Systematic Exploration of a Controversial NotionAsleEikremGod as Sacrificial Love: A Systematic Exploration of a Controversial NotionLondon: Bloomsbury Academic 2018 (Paperback 2019)

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.

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Discovery of a Difluoroglycine Synthesis Method through Quantum Chemical Calculations

10.26434/chemrxiv.11550057 ◽

2020 ◽

Author(s):

Tsuyoshi Mita ◽

Yu Harabuchi ◽

Satoshi Maeda

Keyword(s):

Quantum Chemical Calculations ◽

Experimental Verification ◽

Quantum Chemical ◽

Synthesis Method ◽

Target Product ◽

Systematic Exploration ◽

Hands On ◽

Retrosynthetic Analysis ◽

Synthetic Routes ◽

Verification Process

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.

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Faculty Opinions recommendation of The bioplex network: A systematic exploration of the human interactome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725636362.793517053 ◽

2016 ◽

Author(s):

Laura Trinkle-Mulcahy

Keyword(s):

Human Interactome ◽

Systematic Exploration

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The New Testament and Intellectual Humility

10.1093/oso/9780198799856.001.0001 ◽

2018 ◽

Cited By ~ 1

Author(s):

Grant Macaskill

Keyword(s):

New Testament ◽

Jesus Christ ◽

Holy Spirit ◽

Intellectual Humility ◽

Christian Communities ◽

The New Testament ◽

The Holy Spirit ◽

Sacrificial Love ◽

The One ◽

The Mind

This book examines how the New Testament scriptures might form and foster intellectual humility within Christian communities. It is informed by recent interdisciplinary interest in intellectual humility, and concerned to appreciate the distinctive representations of the virtue offered by the New Testament writers on their own terms. It argues that the intellectual virtue is cast as a particular expression of the broader Christian virtue of humility, which proceeds from the believer’s union with Christ, through which personal identity is reconstituted by the operation of the Holy Spirit. Hence, we speak of ‘virtue’ in ways determined by the acting presence of Jesus Christ, overcoming sin and evil in human lives and in the world. The Christian account of the virtue is framed by this conflict, as believers within the Christian community struggle with natural arrogance and selfishness, and come to share in the mind of Christ. The new identity that emerges creates a fresh openness to truth, as the capacity of the sinful mind to distort truth is exposed and challenged. This affects knowledge and perception, but also volition: for these ancient writers, a humble mind makes good decisions that reflect judgments decisively shaped by the sacrificial love of Jesus Christ. By presenting ‘humility of mind’ as a characteristic of the One who is worshipped—Jesus Christ—the New Testament writers insist that we acknowledge the virtue not just as an admission of human deficiency or limitation, but as a positive affirmation of our rightful place within the divine economy.

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