scholarly journals MODULATION OF RESPIRATORY REACTIONS AT ELECTRICAL STIMULATION OF MAGNUS RAPHE NUCLEUS OF MIDDLE SEAM BEFORE AND AFTER MICROINJECTION OF GABAZIN

2017 ◽  
Vol 19 (6) ◽  
pp. 196-200
Author(s):  
A.O. Orlova
Keyword(s):  
Electrical Stimulation ◽  
Chemical Stimulation ◽  
Raphe Nucleus ◽  
Inhibitory Effects ◽  
Respiratory Parameters ◽  
Before And After ◽  
Stimulation Of

In the article the inhibitory effects on respiratory parameters during electrical or chemical stimulation of the magnus raphe nucleus are induced mainly by the participation of GABA. To elucidate the involvement of GABA

Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs

2005 ◽  
Vol 288 (6) ◽  
pp. G1195-G1198 ◽  
Author(s):  
Shi Liu ◽  
Lijie Wang ◽  
J. D. Z. Chen
Keyword(s):  
Electrical Stimulation ◽  
Inhibitory Effect ◽  
Adrenergic Blockade ◽  
Rectal Compliance ◽  
Rectal Tone ◽  
Before And After ◽  
Sensory Functions ◽  
Sympathetic Pathway ◽  
Colonic Electrical Stimulation ◽  
Stimulation Of

Gastric electrical stimulation (GES) has been shown to alter motor and sensory functions of the stomach. However, its effects on other organs of the gut have rarely been investigated. The study was performed in 12 dogs implanted with two pairs of electrodes, one on the serosa of the stomach and the other on the colon. The study was composed of two experiments. Experiment 1 was designed to study the effects of GES on rectal tone and compliance in nine dogs compared with colonic electrical stimulation (CES). Rectal tone and compliance were assessed before and after GES or CES. Experiment 2 was performed to study the involvement of sympathetic pathway in 8 of the 12 dogs. The rectal tone was recorded for 30–40 min at baseline and 20 min after intravenous guanethidine. GES or CES was given for 20 min 20 min after the initiation of the infusion. It was found that both GES and CES reduced rectal tone with comparable potency. Rectal compliance was altered neither with GES, nor with CES. The inhibitory effect of GES but not CES on rectal tone was abolished by an adrenergic blockade, guanethidine. GES inhibited rectal tone with a comparable potency with CES but did not alter rectal compliance. The inhibitory effect of GES on rectal tone is mediated by the sympathetic pathway. It should be noted that electrical stimulation of one organ of the gut may have a beneficial or adverse effect on another organ of the gut.

Respiratory responses to aortic and carotid chemoreceptor activation in the dog

1991 ◽  
Vol 70 (6) ◽  
pp. 2539-2550 ◽  
Author(s):  
F. A. Hopp ◽  
J. L. Seagard ◽  
J. Bajic ◽  
E. J. Zuperku
Keyword(s):  
Electrical Stimulation ◽  
Carotid Body ◽  
Carotid Sinus ◽  
Chemical Stimulation ◽  
Respiratory Drive ◽  
Carotid Sinus Nerve ◽  
Nerve Activity ◽  
Respiratory Reflexes ◽  
Respiratory Responses ◽  
Stimulation Of

Respiratory responses arising from both chemical stimulation of vascularly isolated aortic body (AB) and carotid body (CB) chemoreceptors and electrical stimulation of aortic nerve (AN) and carotid sinus nerve (CSN) afferents were compared in the anesthetized dog. Respiratory reflexes were measured as changes in inspiratory duration (TI), expiratory duration (TE), and peak averaged phrenic nerve activity (PPNG). Tonic AN and AB stimulations shortened TI and TE with no change in PPNG, while tonic CSN and CB stimulations shortened TE, increased PPNG, and transiently lengthened TI. Phasic AB and AN stimulations throughout inspiration shortened TI with no changes in PPNG or the following TE; however, similar phasic stimulations of the CB and CSN increased both TI and PPNG and decreased the following TE. Phasic AN stimulation during expiration decreased TE and the following TI with no change in PPNG. Similar stimulations of the CB and CSN decreased TE; however, the following TI and PPNG were increased. These findings differ from those found in the cat and suggest that aortic chemoreceptors affect mainly phase timing, while carotid chemoreceptors affect both timing and respiratory drive.

Putative mechanisms involved in excitatory and inhibitory effects of somatostatin on intestinal motility

1989 ◽  
Vol 257 (4) ◽  
pp. G532-G538 ◽  
Author(s):  
T. Takeda ◽  
K. Taniyama ◽  
S. Baba ◽  
C. Tanaka
Keyword(s):  
Electrical Stimulation ◽  
Longitudinal Muscle ◽  
Cholinergic Neuron ◽  
Gamma Aminobutyric Acid ◽  
Inhibitory Effects ◽  
Guinea Pig Ileum ◽  
Excitatory Effect ◽  
Ergic Neuron ◽  
Gabaa Antagonist ◽  
Stimulation Of

The mechanism of action of somatostatin on the motility of intestine was examined in the entire preparation and the longitudinal muscle attached with Auerbach's plexus (LA) preparation of guinea pig ileum, in relation to the cholinergic neuron and gamma-aminobutyric acid (GABA)ergic neuron. Somatostatin produced a transient potentiation of electrical stimulation-induced twitch contractions followed by an inhibition. The excitatory effect of somatostatin was associated with an increase in the release of [3H]acetylcholine (ACh) from the preparations preloaded with [3H]choline. Bicuculline, a GABAA antagonist, inhibited the somatostatin-induced excitatory effect. Somatostatin inhibited the electrical stimulation-induced twitch contraction and release of [3H]ACh, and the inhibition was greater in the entire preparation than in the LA. Phaclofen, a GABAB antagonist, prevented the inhibitory effects of somatostatin. Somatostatin induced a Ca2+ -dependent, tetrodotoxin-sensitive release of [3H]GABA from the preparations preloaded with [3H]GABA. Therefore somatostatin exerts excitatory and inhibitory effects on the cholinergic neuron due to the stimulation of the GABAergic neuron, and the motility of the intestine is regulated.

Electrical Stimulation of the Guinea Pig Cochlea

1987 ◽  
Vol 96 (4) ◽  
pp. 349-361 ◽  
Author(s):  
Mark J. Maslan ◽  
Josef M. Miller
Keyword(s):  
Electrical Stimulation ◽  
Low Frequency ◽  
Damage Threshold ◽  
Auditory Brainstem ◽  
Cochlear Prosthesis ◽  
Before And After ◽  
Auditory Brainstem Evoked Responses ◽  
Straight Lines ◽  
Histopathologic Findings ◽  
Stimulation Of

As a result of practical considerations, histopathologic findings of the temporal bone in humans with cochlear prosthesis implants have been limited. This project attempts to better define safe parameters of electrical stimulation of the inner ear and compare the safe limits of intracochlear vs. extracochlear stimulation sites. Guinea pigs were implanted with single electrodes either on the promontory or in the scala tympani and were stimulated relative to a remote indifferent for 12 hours distributed over a 4-week period. Electrical auditory brainstem evoked responses (EABRs) were tested before and after each of four 3-hour stimulation sessions. Six weeks after implantation, the animals were killed, and their cochleas were examined under the scanning electron microscope. Intracochlear electrodes exhibited thresholds for damage well below one half of that found for most extracochlear stimulation sites. The function-relating damage threshold (in amperes) to frequency of intracochlear stimulation is represented by two straight lines, with an intercept of 1 kHz. The low-frequency limb exhibited a slope of 3 to 4 dB/octave, whereas the high-frequency limb exhibited a slope of 9 to 10 dB/octave. Extracochlear results were too variable to permit speculation. Changes in EABRs were only variably related to histopathologic findings.

Corticofugal Projection Inhibits the Auditory Thalamus Through the Thalamic Reticular Nucleus

2008 ◽  
Vol 99 (6) ◽  
pp. 2938-2945 ◽  
Author(s):  
Zhuo Zhang ◽  
Chun-Hua Liu ◽  
Yan-Qin Yu ◽  
Kenji Fujimoto ◽  
Ying-Shing Chan ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Medial Geniculate Body ◽  
Thalamic Reticular Nucleus ◽  
Reticular Nucleus ◽  
Inhibitory Effects ◽  
Inhibitory Pathway ◽  
Inhibitory Postsynaptic Potentials ◽  
Medial Geniculate ◽  
Inferior Colliculi ◽  
Stimulation Of

Electrical stimulation of the auditory cortex (AC) causes both facilitatory and inhibitory effects on the medial geniculate body (MGB). The purpose of this study was to identify the corticofugal inhibitory pathway to the MGB. We assessed two potential circuits: 1) the cortico-colliculo-thalamic circuit and 2) cortico-reticulo-thalamic one. We compared intracellular responses of MGB neurons to electrical stimulation of the AC following bilateral ablation of the inferior colliculi (IC) or thalamic reticular nucleus (TRN) in anesthetized guinea pigs. Cortical stimulation with intact TRN could cause strong inhibitory effects on the MGB neurons. The corticofugal inhibition remained effective after bilateral IC ablation, but it was minimized after the TRN was lesioned with kainic acid. Synchronized TRN neuronal activity and MGB inhibitory postsynaptic potentials (IPSPs) were observed with multiple recordings. The results suggest that corticofugal inhibition traverses the corticoreticulothalamic pathway, indicating that the colliculi-geniculate inhibitory pathway is probably only for feedforward inhibition.

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