scholarly journals Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases.

2003 ◽  
Vol 50 (4) ◽  
pp. 1147-1154 ◽  
Author(s):  
Jolanta Czuczejko ◽  
Bronisław A Zachara ◽  
Ewa Staubach-Topczewska ◽  
Waldemar Halota ◽  
Józef Kedziora
Keyword(s):  
Liver Disease ◽  
Glutathione Peroxidase ◽  
Chronic Liver Disease ◽  
Peroxidase Activity ◽  
Chronic Liver ◽  
Red Cell ◽  
Glutathione Peroxidase Activity ◽  
Group 2 ◽  
Cryptogenic Chronic Liver Disease ◽  
Group 1

Disturbances in the antioxidant system could play a role in pathogenesis of chronic liver disease. The aim of our study was to evaluate the levels/activities of antioxidants in blood of patients with chronic liver disease. We estimated selenium and glutathione concentrations and glutathione peroxidase activities in blood of 59 patients with chronic hepatitis B or C virus infection (group 1) and 64 patients with alcoholic, autoimmune or cryptogenic chronic liver disease (group 2). The results were compared with 50 healthy controls. Whole blood and plasma selenium and red cell glutathione concentrations were significantly lower in the patients compared with the controls. Red cell glutathione peroxidase activity was slightly reduced in both subgroups of group 1 and in group 2 with normal alanine aminotransferase values. Plasma glutathione peroxidase activity was slightly but significantly higher in patients with elevated aminotransferase values. The findings suggest that disturbances in antioxidant parameters in blood of patients with chronic liver disease may be the cause of the peroxidative damage of cells.

Serum antibodies to thymus epithelial cells in non-A, non-B and cryptogenic chronic liver disease

2008 ◽  
Vol 9 (5) ◽  
pp. 279-287 ◽  
Author(s):  
Fabio Cassaniy ◽  
Federico Tremolada ◽  
Francesco B. Bianchi ◽  
Laura Baffoni ◽  
Luca Selleri ◽  
...  
Keyword(s):  
Liver Disease ◽  
Epithelial Cells ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Serum Antibodies ◽  
Thymus Epithelial Cells ◽  
Cryptogenic Chronic Liver Disease

scholarly journals HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Andreia Silva Evangelista ◽  
Maria Cristina Nakhle ◽  
Thiago Ferreira de Araújo ◽  
Clarice Pires Abrantes-Lemos ◽  
Marta Mitiko Deguti ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Serum Iron ◽  
Genetic Diseases ◽  
Hereditary Hemochromatosis ◽  
Transferrin Saturation ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Chronic Liver ◽  
Group 2

Iron abnormalities in chronic liver disease may be the result of genetic diseases or secondary factors. The present study aimed to identify subjects with HFE-HH in order to describe the frequency of clinical manifestations, identify risk factors for iron elevation, and compare the iron profile of HFE-HH to other genotypes in liver disease patients. A total of 108 individuals with hepatic disease, transferrin saturation (TS) > 45%, and serum ferritin (SF) > 350 ng/mL were tested for HFE mutations. Two groups were characterized: C282Y/C282Y or C282Y/H63D genotypes (n=16) were the HFE hereditary hemochromatosis (HFE-HH) group; and C282Y and H63D single heterozygotes, the H63D/H63D genotype, and wild-type were considered group 2 (n=92). Nonalcoholic liver disease, alcoholism, and chronic hepatitis C were detected more frequently in group 2, whereas arthropathy, hepatocarcinoma, diabetes, and osteoporosis rates were significantly higher in the HFE-HH group. TS > 82%, SF > 2685 ng/mL, and serum iron > 178 μg/dL were the cutoffs for diagnosis of HFE-HH in patients with liver disease. Thus, in non-Caucasian populations with chronic liver disease, HFE-HH diagnosis is more predictable in those with iron levels higher than those proposed in current guidelines for the general population.

Hepatitis G infection: role in cryptogenic chronic liver disease and primary liver cell cancer in the UK

1998 ◽  
Vol 5 (3) ◽  
pp. 165-169 ◽  
Author(s):  
R. C. Hollingsworth ◽  
E. J. Minton ◽  
C. Fraser‐Moodie ◽  
E. Metivier ◽  
P. M. Rizzi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Liver Cell ◽  
Cell Cancer ◽  
Chronic Liver ◽  
Hepatitis G ◽  
Cryptogenic Chronic Liver Disease ◽  
The Uk

scholarly journals Increased glutathione peroxidase activity in alpha-thalassemia

Blood ◽  
1977 ◽  
Vol 50 (4) ◽  
pp. 647-655
Author(s):  
E Beutler ◽  
F Matsumoto ◽  
D Powars ◽  
J Warner
Keyword(s):  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Beta Thalassemia ◽  
Red Cell ◽  
Glutathione Peroxidase Activity ◽  
Alpha Thalassemia ◽  
Thalassemia Trait ◽  
Gshpx Activity ◽  
Increased Activity ◽  
Hemoglobin H Disease

Glutathione peroxidase (GSHPx) activity was found to be greatly elevated in members of a family with alpha-thalassemia. Eleven other families with proven alpha-thalassemia were investigated, and all but one subject with hemoglobin H disease had increased red cell GSHPx. Most persons with alpha-thalassemia trait also had increased activity of red cell GSHPx. In contrast, only very modest increases in glutathione peroxidase activity were observed in subjects with various forms of beta-thalassemia.

Are hepatitis G virus and TT virus involved in cryptogenic chronic liver disease?

2002 ◽  
Vol 34 (1) ◽  
pp. 53-58 ◽  
Author(s):  
R. Di Stefano ◽  
D. Ferraro ◽  
C. Bonura ◽  
G. Pizzolanti ◽  
O. Lo Iacono ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis G Virus ◽  
Tt Virus ◽  
Hepatitis G ◽  
Cryptogenic Chronic Liver Disease

Cryptogenic Chronic Liver Disease and Serum or Liver Hepatitis B Virus Markers

Digestion ◽  
1988 ◽  
Vol 39 (4) ◽  
pp. 251-256 ◽  
Author(s):  
Giulio Diodati ◽  
Patrizia Pontisso ◽  
Paola Bonetti ◽  
Duilio Stenico ◽  
Franco Noventa ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
B Virus ◽  
Cryptogenic Chronic Liver Disease ◽  
Hepatitis B Virus Markers

scholarly journals Hepatitis G virus infection in chronic liver disease

Gut ◽  
1998 ◽  
Vol 42 (1) ◽  
pp. 107-111 ◽  
Author(s):  
M Guilera ◽  
J C Sáiz ◽  
F X López-Labrador ◽  
E Olmedo ◽  
S Ampurdanés ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Blood Donors ◽  
Chronic Liver ◽  
Hepatitis G Virus ◽  
Cryptogenic Chronic Liver Disease

Background—The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood.Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease.Subjects—Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied.Methods—HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5′ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared.Results—The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found.Conclusions—The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.

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