scholarly journals Non-invasive Methods for in vivo Determination of the Skin Barrier Function – Advantages of Confocal Raman Microspectroscopy

2020 ◽  
Vol 20 (3) ◽  
pp. 171-177
Author(s):  
Maxim E. Darvin ◽  
◽  
Chun Sik Choe ◽  
Johannes Schleusener ◽  
Jürgen Lademann ◽  
...  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Raman Microspectroscopy ◽  
Skin Barrier Function ◽  
Non Invasive ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

scholarly journals Current views on non-invasive in vivo determination of physiological parameters of the stratum corneum using confocal Raman microspectroscopy

2022 ◽  
Author(s):  
Maxim E. Darvin ◽  
Johannes Schleusener ◽  
Jürgen Lademann ◽  
Chun-Sik Choe
Keyword(s):  
Stratum Corneum ◽  
Raman Microspectroscopy ◽  
Physiological Parameters ◽  
Skin Barrier Function ◽  
Non Invasive ◽  
Intercellular Lipids ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

Confocal Raman microspectroscopy is widely used in dermatology and cosmetology for analysis of the concentration of skin components (lipids, natural moisturizing factor molecules, water) and the penetration depth of cosmetic/medical formulations in the human stratum corneum (SC) in vivo. In recent years, it was shown that confocal Raman microspectroscopy can also be used for non-invasive in vivo depth-dependent determination of the physiological parameters of the SC, such as lamellar and lateral organization of intercellular lipids, folding properties of keratin, water mobility and hydrogen bonding states. The results showed that the strongest skin barrier function, which is primarily manifested by the orthorhombic organization of intercellular lipids, is provided at ≈20–40% SC depth, which is related to the maximal bonding state of water with surrounding components in the SC. The secondary and tertiary structures of keratin determine water binding in the SC, which is depth-dependent. This paper shows the technical possibility and advantage of confocal Raman microspectroscopy in non-invasive investigation of the skin and summarizes recent results on in vivo investigation of the human SC.

Confocal Raman Microspectroscopy in the Assessment of Skin Barrier Function and Drug Penetration

2021 ◽  
pp. 799-836
Author(s):  
Jacqueline Resende de Azevedo ◽  
Marie-Alexandrine Bolzinger ◽  
Stéphanie Briançon ◽  
Yves Chevalier ◽  
Yuri Dancik
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Raman Microspectroscopy ◽  
Skin Barrier Function ◽  
Drug Penetration ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

scholarly journals In Vivo Confocal Raman Microspectroscopy of the Skin: Noninvasive Determination of Molecular Concentration Profiles

2001 ◽  
Vol 116 (3) ◽  
pp. 434-442 ◽  
Author(s):  
Peter J. Caspers ◽  
Hajo A. Bruining ◽  
Gerwin J. Puppels ◽  
Gerald W. Lucassen ◽  
Elizabeth A. Carter
Keyword(s):  
Raman Microspectroscopy ◽  
Concentration Profiles ◽  
Molecular Concentration ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

Topical Formulation Containing Beeswax-Based Nanoparticles Improved In Vivo Skin Barrier Function

2017 ◽  
Vol 18 (7) ◽  
pp. 2505-2516 ◽  
Author(s):  
Carla Souza ◽  
Luis Alexandre Pedro de Freitas ◽  
Patrícia Maria Berardo Gonçalves Maia Campos
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Topical Formulation

Assessment of the “Skin Reservoir” of Urea by Confocal Raman Microspectroscopy and Reverse Iontophoresis in vivo

2007 ◽  
Vol 24 (10) ◽  
pp. 1897-1901 ◽  
Author(s):  
Valentine Wascotte ◽  
Peter Caspers ◽  
Johanna de Sterke ◽  
Michel Jadoul ◽  
Richard H. Guy ◽  
...  
Keyword(s):  
Raman Microspectroscopy ◽  
Reverse Iontophoresis ◽  
Skin Reservoir ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman
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