scholarly journals Effect of Intravenous Tranexamic Acid on Perioperative Blood Loss in Orthognathic Surgery

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Dr Shameer P ◽  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Orthognathic Surgery ◽  
Perioperative Blood Loss

Tranexamic Acid in Thoracic and Lumbar Fusions and Perioperative Blood Loss

2019 ◽  
Vol 32 (10) ◽  
pp. E462-E468 ◽  
Author(s):  
Nathan Wanderman ◽  
William Robinson ◽  
Bayard Carlson ◽  
Mohamad Bydon ◽  
Brad Currier ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Perioperative Blood Loss

scholarly journals Efficacy and Safety of Tranexamic Acid in Bimaxillary Orthognathic Surgery

2020 ◽  
Vol 28 (2) ◽  
pp. 94-104
Author(s):  
Liang Sun ◽  
Rui Guo ◽  
Yi Feng
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Orthognathic Surgery ◽  
Operation Time ◽  
Controlled Trials ◽  
Allogenic Blood Transfusion ◽  
Intraoperative Blood Loss ◽  
Irrigation Fluid ◽  
Allogenic Blood

Background: Tranexamic acid (TXA) has been widely used during craniofacial and orthognathic surgery (OS). However, results of the literature are inconsistent due to specific type of surgery and a small sample of studies. The purpose of this study was to evaluate the role of TXA in bimaxillary OS. Methods: We performed a comprehensive literature search of PubMed, Cochrane Central Register of Controlled Trials, and EMBASE to identify randomized controlled trials (RCTs) that compared effect of TXA on bimaxillary OS with placebo. Outcomes of interests included intraoperative blood loss, allogenic transfusion, operation time, and volume of irrigation fluid. Random effects models were chosen considering that heterogeneity between studies was anticipated, and I 2 statistics were used to test for the presence of heterogeneity. Results: Totally 6 RCTs were identified. Tranexamic acid resulted in significantly reduced intraoperative blood loss (weighted mean difference [WMD] = −264.82 mL; 95% CI: −380.60 to −149.04 mL) and decreased amounts of irrigation fluid (WMD = −229.23 mL; 95% CI: −399.63 to −58.83 mL). However, TXA had no remarkable impact on risk of allogenic blood transfusion (pooled risk ratio = 0.50; 95% CI: 0.20-1.23), operation time (WMD = −8.71 min; 95% CI: −20.98 to 3.57 min), and length of hospital stay (WMD = −0.24 day; 95% CI: −0.62 to 0.14 day). No TXA-associated severe adverse reactions or complications were observed. Conclusions: Currently available meta-analysis reveals that TXA is effective in decreasing intraoperative blood loss; however, it does not reduce the risk of allogenic blood transfusion in bimaxillary OS.

scholarly journals The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis

Medicine ◽  
2018 ◽  
Vol 97 (50) ◽  
pp. e13643 ◽  
Author(s):  
Peng Xue ◽  
Junsong Yang ◽  
Xiaozhou Xu ◽  
Tuanjiang Liu ◽  
Yansheng Huang ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Stenosis ◽  
Efficacy And Safety ◽  
Perioperative Blood Loss ◽  
Thoracic Spinal Stenosis ◽  
Thoracic Spinal

Comparison of Oral and Intravenous Tranexamic Acid for Prevention of Perioperative Blood Loss in Total Knee and Total Hip Arthroplasty

2017 ◽  
Vol 52 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Mary Alice Gortemoller ◽  
Bryan Allen ◽  
Rochelle Forsyth ◽  
Kimberly Theiss ◽  
Kristal Cunningham ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Retrospective Chart Review ◽  
Study Groups ◽  
Total Hip ◽  
Perioperative Blood Loss ◽  
Total Knee ◽  
Noninferiority Margin

Background: Tranexamic acid (TA) is an antifibrinolytic agent that prevents perioperative blood loss in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). This benefit has been established with the intravenous (IV) dosage form, but there is limited evidence evaluating oral TA in this setting. Objective: To compare the effect of oral versus IV TA on perioperative blood loss in those undergoing TKA or THA. Methods: In this single-centered retrospective chart review, participants at least 18 years of age who received IV or oral TA from a single surgeon who performed their THA or TKA were included. The primary outcome evaluated hemoglobin (Hgb) reduction. Power analysis determined that 165 participants were required in each group to achieve 80% power, with a noninferiority margin of 0.3 mg/dL. Results: Both study groups included 165 participants. Oral TA was noninferior to IV TA (Hgb difference = −0.12 g/dL [95% CI = −0.28 to 0.05; P = 0.0250]). A subgroup analysis of THA and TKA revealed that oral TA was noninferior to IV TA in THA (Hgb difference = 0.24 g/dL [95% CI = −0.17 to 0.5]), but oral TA failed to meet the noninferiority margin in the TKA subgroup (Hgb difference = −0.20 [95% CI = −0.38 to −0.02]). Conclusion: This study provides evidence that oral TA is a clinically effective and cost-efficient alternative to IV TA in the setting of THA and TKA.

Tranexamic Acid Reduces Perioperative Blood Loss in Adult Patients Having Spinal Fusion Surgery

2008 ◽  
Vol 107 (5) ◽  
pp. 1479-1486 ◽  
Author(s):  
Jean Wong ◽  
Hossam El Beheiry ◽  
Yoga Raja Rampersaud ◽  
Stephen Lewis ◽  
Henry Ahn ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Adult Patients ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery ◽  
Perioperative Blood Loss

scholarly journals Szükség van szívódrénre elektív csípőprotézis-műtétek során?

2016 ◽  
Vol 157 (29) ◽  
pp. 1171-1176
Author(s):  
Tibor Major ◽  
András Bikov ◽  
Gergely Holnapy ◽  
Zoltán Bejek ◽  
Bernadett Bakos ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Transfusion Requirement ◽  
Postoperative Hemorrhage ◽  
Thrombosis Prophylaxis ◽  
Suction Drainage ◽  
Septic Complications ◽  
Suction Drain ◽  
Perioperative Blood Loss

Introduction: Several studies have been published which questioned the use of suction drain during elective hip arthroplasty. Aim: In this prospective study the authors examined how the use of suction drainage affected complications related to perioperative blood loss and hemorrhage in patients undergoing elective hip arthroplasty. Method: Eighty-six patients undergoing elective hip arthroplasty were divided into two groups. In 54 patients (“drain” group) suction drains were used during operation, whereas in 32 patients no suction drain was applied. Perioperative blood loss, use of tranexamic acid, method of thrombosis prophylaxis, transfusion requirement, incidental postoperative hemorrhage, septic complications, and all other postoperative complications were recorded. Results: Perioperative blood loss was affected with the use of tranexamic acid but not with the use of drainage (p = 0.94). Patients without the use of drain showed a tendency of lower transfusion requirement (p = 0.08). There was no correlation between any complications and the use of drainage. Conclusion: In accordance with published results the authors conclude that the routine use of suction drainage during elective hip arthroplasty is not definitely necessary. Orv. Hetil., 2016, 157(29), 1171–1176.

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