Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Composite Nanosilver (AgNPs) - Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study

Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim: the aim was to evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried, and the results showed that the percentage of a reduction rate of the ulcer by the third week of the treatment as in the hydrogel/nano silver-based dressing group was higher (15.11%) than traditional wound dressing group (33.44%). Moreover, the mean ulcers size "sq mm" in the hydrogel/nano silver-based dressing group recognized a faster healing rate (15.11 ± 7.89), and considerably lesser in comparison to the traditional by the third week (21.65 ± 8.4). Conclusion: The hydrogel/nanosilver-based dressing showed better results than traditional dressing in managing diabetic ulcer foot. Keywords: Diabetes, Wound, Diabetic ulcer, Wound dressing, Nanomedicine, Nano-silver.

Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Nanosilver Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study

Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim:To evaluate the effectiveness of using hydrogel/nanosilver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods:Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried Results: The results showed that the percentage of a reduction rate of the ulcer by the third week of the treatment as in the hydrogel/nanosilver-based dressing group was higher (15.11%) than traditional wound dressing group (33.44%). Moreover, the mean ulcers size "sq mm" in the hydrogel/nanosilver-based dressing group recognized a faster healing rate (15.11±7.89), and considerably lesser in comparison to the traditional in the third week (21.65±8.4). Conclusion: The hydrogel/nanosilver-based dressing showed better results than traditional dressing in managing diabetic ulcer foot. Keywords: Diabetes, Wound Care, Diabetic Foot, Wound dressing, Hydrogel Nanosilver

COMPARISON OF KETOFOLAND PROPOFOL IN INTRACRANIALANEURYSMAL CLIPPING SURGERY: A PROSPECTIVE RANDOMIZED CONTROL STUDY

Background: Haemodynamic stability is the major goal of anaesthesia during intracranial aneurysm clipping . In the present study, we compared the effects of ketofol with propofol alone, used as an induction and maintenance agent during surgical clipping of intracranial aneurysm. Material and methods - Forty patients aged 18 to 75 years, posted for aneurysm neck clipping following aneurysmal Subarachnoid haemorrhage (SAH) were included in the study. The patients were randomized into two groups. One group received combination of ketamine and propofol (1:5 ratio) (Group KP) and the other propofol (Group P) for induction and maintenance of anaesthesia. Results - Combination of Ketamine and propofol ( in the ratio of 1:5) which was used in this study provided for better maintenance of Mean Arterial Pressure(MAP) during induction and maintenance of anaesthesia. Conclusion – Ketofol compared to propofol alone provides better hemodynamic stability on induction as well as during maintenance of anaesthesia in intracranial aneurysmal clipping surgery without increasing intracranial pressure.