scholarly journals Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis

Aging ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 21345-21363
Author(s):  
Li Cai ◽  
Beihai Ge ◽  
Shengbo Xu ◽  
Xiangwen Chen ◽  
Hong Yang
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Blood Brain Barrier Damage

Blood-brain barrier damage during the acute stage of subarachnoid hemorrhage, as exemplified by a new animal model

Neurosurgery ◽  
1986 ◽  
Vol 18 (6) ◽  
pp. 733???9 ◽  
Author(s):  
T D??czi ◽  
F Jo?? ◽  
G Ad??m ◽  
B Boz??ky ◽  
P Szerdahelyi
Keyword(s):  
Animal Model ◽  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
Acute Stage ◽  
Brain Barrier ◽  
Blood Brain ◽  
Blood Brain Barrier Damage

Blood-Brain Barrier Damage during the Acute Stage of Subarachnoid Hemorrhage, as Exemplified by a New Animal Model

Neurosurgery ◽  
1986 ◽  
Vol 18 (6) ◽  
pp. 733-739 ◽  
Author(s):  
Tamás Dóczi ◽  
Ferenc Joó ◽  
Géza Ádám ◽  
Béla Bozóky ◽  
Péter Szerdahelyi
Keyword(s):  
Animal Model ◽  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
Acute Stage ◽  
Brain Barrier ◽  
Blood Brain ◽  
Blood Brain Barrier Damage

scholarly journals MAP4K4 induces early blood-brain barrier damage in a murine subarachnoid hemorrhage model

2021 ◽  
Vol 16 (2) ◽  
pp. 325
Author(s):  
Peng-Yu Pan ◽  
Guo-Biao Liang ◽  
Zheng Zou ◽  
Yu-Shu Dong ◽  
Dong-Dong Liu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Blood Brain Barrier Damage

Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S266-S266
Author(s):  
Roland Veltkamp ◽  
Li Sun ◽  
Dirk A Siebing ◽  
Katja Bieber ◽  
Sabine Heiland ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Hyperbaric Oxygen ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Transient Focal Cerebral Ischemia ◽  
Blood Brain Barrier Damage

Baicalin protects LPS-induced blood–brain barrier damage and activates Nrf2-mediated antioxidant stress pathway

2021 ◽  
Vol 96 ◽  
pp. 107725
Author(s):  
Xin Wang ◽  
Jia-ying Yu ◽  
Yan Sun ◽  
Heng Wang ◽  
Hu Shan ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Antioxidant Stress ◽  
Stress Pathway ◽  
Blood Brain Barrier Damage

scholarly journals Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172784 ◽  
Author(s):  
Yanjiang Li ◽  
Heng Yang ◽  
Wei Ni ◽  
Yuxiang Gu
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

scholarly journals The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats Are Possibly Mediated by Preventing Blood–Brain Barrier Disruption and RIP3-Mediated Necroptosis

2019 ◽  
Vol 28 (11) ◽  
pp. 1358-1372 ◽  
Author(s):  
Jingsen Chen ◽  
Hanghuang Jin ◽  
Hangzhe Xu ◽  
Yucong Peng ◽  
Liyong Jie ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
New Drugs ◽  
Brain Barrier ◽  
Lesion Volume ◽  
Brain Swelling ◽  
Neuroprotective Effects ◽  
Pharmaceutical Therapy ◽  
Blood Brain

Despite the substantial efforts to elucidate the role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues to be unavailable. This study aims to reveal the role of necroptosis after SAH, and explore whether the disruption of the blood–brain barrier (BBB) and RIP3-mediated necroptosis following SAH in a rat SAH model are altered by necrostatin-1 via its selective inhibition of receptor-interacting protein kinase 1 (RIP1). Sixty-five rats were used in the experiments. The SAH model was established using endovascular perforation. Necrostatin-1 was intracerebroventricularly injected 1 h before SAH induction. The neuroprotective effects of necrostatin-1 were evaluated with multiple methods such as magnetic resonance imaging (MRI) scanning, immunohistochemistry, propidium iodide (PI) labeling, and western blotting. Pretreatment with necrostatin-1 attenuated brain swelling and reduced the lesion volume on T2 sequence and ventricular volume on MRI 72 h after SAH induction. Albumin leakage and the degradation of tight junction proteins were also ameliorated by necrostatin-1 administration. In addition, necrostatin-1 decreased the number of PI-positive cells in the basal cortex, reduced the levels of the RIP3 and MLKL proteins, and inhibited the production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Based on the findings from the present study, the selective RIP1 inhibitor necrostatin-1 functioned as a neuroprotective agent after SAH by attenuating brain swelling and BBB disruption. Moreover, the necrostatin-1 pretreatment prevented SAH-induced necroptosis by suppressing the activity of the RIP3/MLKL signaling pathway. These results will provide insights into new drugs and pharmacological targets to manage SAH, which are worth further study.

scholarly journals Semaphorin 3A Contributes to Secondary Blood–Brain Barrier Damage After Traumatic Brain Injury

2019 ◽  
Vol 13 ◽  
Author(s):  
Mengchen Yang ◽  
Xiaoxue Wang ◽  
Yueshan Fan ◽  
Yaqing Chen ◽  
Dongdong Sun ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Semaphorin 3A ◽  
Blood Brain ◽  
Blood Brain Barrier Damage

Angiopoietin-like protein 1 decreases blood brain barrier damage and edema following focal cerebral ischemia in mice

2008 ◽  
Vol 52 (3) ◽  
pp. 470-477 ◽  
Author(s):  
Dar-Ming Lai ◽  
Hung Li ◽  
Chin-Cheng Lee ◽  
Yi-Shiuan Tzeng ◽  
Yu-Hsuan Hsieh ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Blood Brain Barrier Damage
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