scholarly journals Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients

Aging ◽  
2021 ◽  
Author(s):  
Do Thi Minh Xuan ◽  
Chung-Che Wu ◽  
Tzu-Jen Kao ◽  
Hoang Dang Khoa Ta ◽  
Gangga Anuraga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Immune Infiltration ◽  
Proteasome 26S

scholarly journals Correlation of immune infiltration with clinical outcomes in breast cancer patients: The 25‐gene prognostic signatures model

2021 ◽  
Author(s):  
Yushan Liu ◽  
Wenfen Fu ◽  
Wei Chen ◽  
Yuxiang Lin ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Breast Cancer Patients ◽  
Immune Infiltration

scholarly journals CXCL2 as a Prognostic Marker in Breast Cancer is Associated with Immune Infiltration and Regulated by miR-215

2020 ◽  
Author(s):  
Jia-Xiang An ◽  
Ying-Ying Chen ◽  
Zhao-Sheng Ma ◽  
Wen-Jie Yu ◽  
Jin-Xi Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Time ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Clinical Prognosis ◽  
Immune Infiltration ◽  
Kaplan Meier ◽  
The Impact ◽  
Kaplan Meier Plotter ◽  
Low Expression

Abstract Background: CXCL2 is a part of chemokine superfamily, which encodes secretory proteins involved in immune regulation and inflammation. The correlation between CXCL2 and prognosis of different cancers, tumor infiltrating lymphocytes are not clear. Methods: We analyzed the expression of CXCL2 and its effect on clinical prognosis through Oncomine database, Tumor Immune Estimation Resource (TIMER) website, Kaplan-Meier plotter, PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA). TIMER and GEPIA were used to analyze the correlation between CXCL2 and the gene marker of immune infiltration. StarBase was used to predict the miRNA that may regulate CXCL2. The relationship between miR-532-5p and CXCL2 was detected by qRT-PCR. Kaplan-Meier plotter was used to evaluate the impact of miR-532-5p on clinical prognosis. Results: PrognoScan, Kaplan-Meier plotter and GEPIA database analysis showed that low expression of CXCL2 was associated with poor disease-specific survival time (DSS), relapse-free survival time (RFS) and overall disease survival (OS) in breast cancer patients. In addition, low expression of CXCL2 was associated with poor OS and RFS in patients with lymph node positive breast cancer. CXCL2 expression was positively correlated with the infiltration of B cells, CD4+T and CD8+T cells, neutrophils and dendritic cells (DCs) in BRCA, mainly in Luminal breast cancer. MiR-532-5p can directly regulate CXCL2 expression. High miR-532-5p expression is significantly correlated with HER2 negative, grade 2 and 3 and poor OS in patients with HER+ER- breast cancer. Conclusion: CXCL2 is closely related to the prognosis and immune infiltration level of breast cancer patients, it can be regulated by miR-532-5p.

scholarly journals Interaction between Molecular Subtypes and Stromal Immune Infiltration before and after Treatment in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

2019 ◽  
Vol 25 (22) ◽  
pp. 6731-6741 ◽  
Author(s):  
Anne-Sophie Hamy ◽  
Hélène Bonsang-Kitzis ◽  
Diane De Croze ◽  
Enora Laas ◽  
Lauren Darrigues ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Molecular Subtypes ◽  
Breast Cancer Patients ◽  
Immune Infiltration ◽  
Before And After

scholarly journals High expression of DLL3 is associated with a poor prognosis and immune infiltration in invasive breast cancer patients

2021 ◽  
Vol 14 (7) ◽  
pp. 101080
Author(s):  
Chong Yuan ◽  
Kaili Chang ◽  
Chenyue Xu ◽  
Qingquan Li ◽  
Zunguo Du
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Breast Cancer ◽  
Poor Prognosis ◽  
High Expression ◽  
Breast Cancer Patients ◽  
Immune Infiltration

Bisphosphonates in Breast Cancer Patients with Skeletal Metastases

1994 ◽  
Vol 8 (1) ◽  
pp. 153-163 ◽  
Author(s):  
Charles L. Shapiro
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Skeletal Metastases ◽  
Breast Cancer Patients
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