scholarly journals Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice

Oncotarget ◽  
2016 ◽  
Vol 7 (28) ◽  
pp. 43907-43923 ◽  
Author(s):  
Anne-Maria Pajari ◽  
Essi Päivärinta ◽  
Lassi Paavolainen ◽  
Elina Vaara ◽  
Tuuli Koivumäki ◽  
...  
Keyword(s):  
Cell Migration ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Colon Carcinoma ◽  
Carcinoma Cells ◽  
Phosphatidylinositol 3 Kinase ◽  
Akt Activation ◽  
Colon Carcinoma Cells ◽  
Hepatocyte Growth ◽  
Phosphatidylinositol 3

scholarly journals N-WASP and WAVE2 Acting Downstream of Phosphatidylinositol 3-Kinase Are Required for Myogenic Cell Migration Induced by Hepatocyte Growth Factor

2004 ◽  
Vol 279 (52) ◽  
pp. 54862-54871 ◽  
Author(s):  
Kazuhiro Kawamura ◽  
Kazunori Takano ◽  
Shiro Suetsugu ◽  
Shusaku Kurisu ◽  
Daisuke Yamazaki ◽  
...  
Keyword(s):  
Cell Migration ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Myogenic Cell ◽  
Phosphatidylinositol 3 Kinase ◽  
Hepatocyte Growth ◽  
Phosphatidylinositol 3

Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway

1998 ◽  
Vol 111 (8) ◽  
pp. 1039-1049 ◽  
Author(s):  
R. Herrera
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Motility ◽  
Tyrosine Phosphorylation ◽  
Colon Carcinoma ◽  
Mapk Pathway ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Ht29 Cells ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF)/scatter factor modulates the motility of HT29 colon carcinoma cells in vitro by inducing morphological changes that depend on the type of extra-cellular matrix (ECM) ligand; HGF-induced scattering of HT29 cells is observed if cells are grown on plastic coated with serum proteins but not laminin. The absence of scattering correlates with a lack of cell spreading on laminin and it is not due to impaired HGF induced tyrosine phosphorylation of the E-cadherin/desmosome component, (gamma)-catenin, or lack of activation of mitogen activated protein kinase (MAPK). Treatment of HT29 cells with phorbol 12-myristate, 13-acetate (PMA), but not arachidonic acid, restored the ability of the cells to spread on laminin in an integrin-dependent manner. Moreover, the addition of both PMA and HGF restored the ability of these cells to scatter on laminin in a synergistic manner. This event correlated with increased tyrosine phosphorylation of paxillin and activation of MAPK. Moreover, when the MEK (MAPK kinase)/MAPK pathway was blocked by the MEK inhibitor PD098059, HGF-induced scattering of HT29 cells was blocked. Thus, HGF modulation of HT29 cell motility is regulated by both integrin and growth factor-dependent signaling and implicates MAPK in the modulation of intercellular adhesion and epithelial cell motility.

scholarly journals Hepatocyte Growth Factor Induces Glucose Uptake in 3T3-L1 Adipocytes through A Gab1/Phosphatidylinositol 3-Kinase/Glut4 Pathway

2007 ◽  
Vol 282 (14) ◽  
pp. 10325-10332 ◽  
Author(s):  
Adeline Bertola ◽  
Stéphanie Bonnafous ◽  
Mireille Cormont ◽  
Rodolphe Anty ◽  
Jean-François Tanti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Glucose Uptake ◽  
Phosphatidylinositol 3 Kinase ◽  
Hepatocyte Growth ◽  
Phosphatidylinositol 3
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