scholarly journals Systemic lupus erythematosus with lupus-nephritis at advanced age (case report)

2017 ◽  
Vol 95 (2) ◽  
pp. 168-172
Author(s):  
Mariya Z. Kanevskaya ◽  
O. M. Kuznetsova
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Case Report ◽  
Lupus Nephritis ◽  
Renal Insufficiency ◽  
Total Dose ◽  
Lupus Erythematosus ◽  
Clinical Case ◽  
Systemic Lupus ◽  
Good Outcome

We report a clinical case of SLE in a women affected at the age of 63 years who had recurrent nephrotic syndrome with the development of renal insufficiency at the onset and a good outcome of therapy with a large total dose cyclophosphamide.

scholarly journals A patient with systemic lupus erythematosus and lupus nephritis: A 12-year follow-up

2011 ◽  
Vol 68 (8) ◽  
pp. 705-708
Author(s):  
Natasa Jovanovic ◽  
Jasmina Markovic-Lipkovski ◽  
Stevan Pavlovic ◽  
Biljana Stojimirovic
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Mycophenolate Mofetil ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Kidney Biopsy ◽  
Immunosuppressive Drugs ◽  
Systemic Lupus ◽  
Younger Women ◽  
The Right

Introduction. Systemic lupus erythematosus (SLE) is a chronic immunological disease causing a significant morbidity and mortality in younger women and involving several organs and systems, most often the kidneys, being consequently the incidence of lupus nephritis (LN) about 60%. Case report. We reported a 57 year-old patient with the diagnosed SLE in 1995. Pathohistological analysis of kidney biopsy revealed LN type V. The patient was treated with corticosteroid pulses and azathioprine during one year. A remission was achieved and maintained with prednisone, 15 mg daily. Nephrotic relapse was diagnosed in 2006 and the second kidney biopsy revealed recent kidney infarction due to extensive vasculitis. Soon, a cerebrovascul insult developed and CT-scan revealed endocranial infarctus. The patient was treated with corticosteroids and cyclophosphamide pulses (totally VI monthly pulses), and also with low-molecular heparine, anticoagulants and salicylates because of the right leg phlebothrombosis. After the pulses, the patient was adviced to take prednisone 20 mg daily and azothioprine 100 mg daily, and 6 months later mycophenolate mofetil because of persistent active serological immunological findings (ANA 1 : 320) and nephrotic syndrome. Mycophenolate mofetil was efficient in inducing and maintaining remission of nephrotic syndrome. Conclusion. The aim of LN treatment is to achieve and maintain remission, improve patients? outcome, reduce the toxicity of immunosuppressive drugs and the incidence of relapses. Mycophenolate mofetil was shown to be efficient in inducing and maintaining remission of nephrotic syndrome in the frame of LN.

Gastrointestinal vasculitis due to systemic lupus erythematosus treated with rituximab: a case report

Lupus ◽  
2020 ◽  
Vol 29 (6) ◽  
pp. 640-643
Author(s):  
Gökçe Kenar ◽  
Kadri Atay ◽  
Gül Emek Yüksek ◽  
Burak Öz ◽  
Süleyman Serdar Koca
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Abdominal Pain ◽  
Case Report ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Immunosuppressive Treatment ◽  
Rapid Progression ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Systemic Lupus

Background Patients with systemic lupus erythematosus may present with variable gastrointestinal manifestations including peritonitis, pancreatitis, enteritis, and vasculitis. Gastrointestinal vasculitis is one of the most devastating complications of systemic lupus erythematosus, with a mortality rate of 50% when it progresses to bowel ischemia and is complicated by hemorrhage or perforation. Case report A young female patient known to have systemic lupus erythematosus, lupus nephritis, and antiphospholipid antibody syndrome, on immunosuppressive treatment presented to the emergency department with acute abdominal pain and nausea. The clinical findings were first associated with an acute flare of lupus nephritis according to the assessments with active laboratory parameters. However, over a short time the abdominal pain worsened and was accompanied by peritonitis and gastrointestinal hemorrhage. The computed tomography scans demonstrated a dilated bowel and thickening of the bowel compatible with gastrointestinal vasculitis. The upper and lower gastrointestinal endoscopy supported the diagnosis of vasculitis by showing multiple ulcerative lesions along the gastrointestinal tract. The patient was successfully treated with pulse corticosteroids urgently, with a fast response to subsequent rituximab therapy without any relapses. Treatment with cyclophosphamide was not preferred because the patient had a high cumulative dose. Conclusion Gastrointestinal vasculitis should be a primary differential diagnosis in patients with systemic lupus erythematosus presenting with abdominal pain because of its rapid progression and high mortality. The treatment choice has been suggested as cyclophosphamide for severe cases in the literature. In this case report, a patient successfully treated with rituximab without any relapses was documented.

scholarly journals Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report

2013 ◽  
pp. 71 ◽  
Author(s):  
Shafaat Husain Talib ◽  
Sonali Bhattu ◽  
Ravindra Bhattu ◽  
Shreyas Deshpande ◽  
Devidas Dhiphale
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Nephritis ◽  
Dengue Fever ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals COVID-19 triggered systemic lupus erythematosus in a child: a case report

2021 ◽  
Vol 8 (7) ◽  
pp. 1304
Author(s):  
Krishna Prasad Maram ◽  
Venkata Rama Rao Paturi ◽  
Lalitha Sudha Alla ◽  
Murali Krishna Bhagavatula
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Nephritis ◽  
Inflammatory Response ◽  
Organ Dysfunction ◽  
Lupus Erythematosus ◽  
Immune Disorders ◽  
Systemic Lupus ◽  
Pediatric Systemic Lupus Erythematosus ◽  
Second Wave

The COVID-19 pandemic has continued to wreak havoc globally during the second wave. Even though it tends to be asymptomatic or cause only a trivial illness in children, it is reported to be associated with a delayed hyper-inflammatory response syndrome resulting in multi-organ dysfunction in children. It is possible that through unknown mechanisms, it could also result in triggering of other auto-immune disorders. We report a case of pediatric systemic lupus erythematosus (SLE) with lupus nephritis suspected to be triggered by SARS-CoV-2 virus which is not reported in the literature so far.

scholarly journals Pincer nails in a patient with systemic lupus erythematosus and lupus nephritis: A case report

2016 ◽  
Vol 2 (3) ◽  
pp. 233-235 ◽  
Author(s):  
Emily V. Twigg ◽  
Nicole A. Weitz ◽  
Richard K. Scher ◽  
Marc E. Grossman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Postpartum nephrotic syndrome related to new onset of systemic lupus erythematosus: A case report

2018 ◽  
Vol 20 ◽  
pp. e00083
Author(s):  
Charalampos Karachalios ◽  
Panagiotis Bakas ◽  
Anastasia Beta ◽  
Efthimios Deligeoroglou
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
New Onset

scholarly journals Síndrome nefrótica em mulher jovem – Nem tudo é Lupus! - Nephrotic syndrome in young woman - Not everything is Lupus!

2017 ◽  
Vol 5 (1) ◽  
pp. 75
Author(s):  
Isabel Carolina Veríssimo Vendramini ◽  
Danielle Pereira Barros ◽  
Úrsula Soares Barbosa ◽  
Vanessa De Oliveira Magalhães ◽  
Nilzio Antônio da Silva ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Laboratory Tests ◽  
Young Female ◽  
Sexual History ◽  
Systemic Lupus ◽  
Oral Ulcers ◽  
Systemic Lupus Erythematosus Case

ResumoObjetivo: Apresentar um caso de síndrome nefrótica, secundária a sífilis, mimetizando Lupus Eritematoso Sistemico. Relato do caso: Mulher jovem, de 26 anos, evoluiu com úlceras orais dolorosas, artralgia e síndrome nefrótica, sendo aventada, inicialmente, a possibilidade de doença autoimune. Os resultados dos exames laboratoriais afastaram a possibilidade de lupus eritematoso sistêmico e confirmaram o diagnóstico de sífilis. Considerações finais: A presença de síndrome nefrótica, em paciente jovem do gênero feminino, deve suscitar a investigação da história sexual pregressa, sendo a sífilis uma possibilidade obrigatória nesta investigação, a qual pode mimetizar o LES, retardando o diagnóstico precoce e o tratamento eficaz.Palavras-chave:Lupus eritematoso sistêmico. Síndrome nefrótica. SífilisAbstractObjective: To present a case of nephrotic syndrome, secondary to syphilis, mimicking systemic lupus erythematosus. Case report: 26-year-old woman who developed painful oral ulcers, arthralgia and nephrotic syndrome, and the possibility of autoimmune disease was initially suggested. The results of the laboratory tests removed the possibility of systemic lupus erythematosus and confirmed the diagnosis of syphilis. Final considerations: The presence of nephrotic syndrome in a young female patient should trigger the investigation of previous sexual history, and syphilis is a mandatory possibility in this investigation, which can mimic SLE, delaying early diagnosis and effective treatment.Keyword:Systemic lupus erythematosus. Nephrotic syndrome. Syphilis.

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