Clinical Effects of Periodontal Therapy on the Severity of Cyclosporin A-Induced Gingival Hyperplasia

Sitafloxacin (STFX) is a newly developed quinolone that has robust antimicrobial activity against periodontopathic bacteria. We previously reported that oral administration of STFX during supportive periodontal therapy was as effective as conventional mechanical debridement under local anesthesia microbiologically and clinically for 3 months. The aim of the present study was to examine the short-term and long-term microbiological and clinical effects of systemic STFX and azithromycin (AZM) on active periodontal pockets during supportive periodontal therapy. Fifty-one patients receiving supportive periodontal therapy were randomly allocated to the STFX group (200 mg/day of STFX for 5 days) or the AZM group (500 mg/day of AZM for 3 days). The microbiological and clinical parameters were examined until 12 months after the systemic administration of each drug. The concentration of each drug in periodontal pockets and the antimicrobial susceptibility of clinical isolates were also analyzed. The proportions of red complex bacteria, i.e.,Porphyromonas gingivalis,Treponema denticola, andTannerella forsythia, which are the representative periodontopathic bacteria, were significantly reduced at 1 month and remained lower at 12 months than those at baseline in both the STFX and AZM groups. Clinical parameters were significantly improved over the 12-month period in both groups. An increase in the MIC of AZM against clinical isolates was observed in the AZM group. These results indicate that monotherapy with systemic STFX and AZM might be an alternative treatment during supportive periodontal therapy in patients for whom invasive mechanical treatment is inappropriate. (This study has been registered with the University Hospital Medical Information Network-Clinical Trials Registry [UMIN-CTR] under registration number UMIN000007834.)

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Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis

Biomolecules ◽

10.3390/biom11101491 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1491

Author(s):

Iwona Olszewska-Czyz ◽

Kristina Kralik ◽

Jelena Prpic

Keyword(s):

Hyaluronic Acid ◽

Clinical Results ◽

Periodontal Therapy ◽

Control Group ◽

Controlled Clinical Trial ◽

Clinical Effects ◽

Clinical Parameters ◽

Randomized Controlled ◽

Probing Depth ◽

Dental Applications

The biological activity of hyaluronic acid (HA) has been well-researched during the past decades; however, there are few randomized, controlled trials of its clinical effects in periodontal therapy. The purpose of this study was to evaluate the effect of hyaluronic acid on the principal parameters of periodontal healing. A specific, commercially available formulation designed and registered for professional dental application, composed of 16 mg/mL of cross-linked and 2 mg/mL of non-cross-linked HA, was used as an adjunctive to non-surgical periodontal therapy, and clinical parameters were evaluated after 3 months. The addition of HA to periodontal therapy demonstrated more favorable clinical results regarding reduction in inflammation, measured by bleeding on probing (−6% compared to the control group) and gain in periodontal attachment (1 mm more than control group), while it had no effect on probing depth reduction. No side effects were reported. Our study demonstrated that HA is a safe and easy-to-use biological agent; due to its wide array of properties, it may significantly improve the results of periodontal therapy. However, more long-term studies are needed to investigate whether these favorable effects remain over time.

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Clinical Effects of Electromagnetic Stimulation as an Adjunct to Periodontal Therapy

Journal of Periodontology ◽

10.1902/jop.1988.59.1.46 ◽

1988 ◽

Vol 59 (1) ◽

pp. 46-52 ◽

Cited By ~ 4

Author(s):

B. Steffensen ◽

R. G. Caffesse ◽

C. T. Hanks ◽

J. K. Avery ◽

N. Wright

Keyword(s):

Periodontal Therapy ◽

Clinical Effects ◽

Electromagnetic Stimulation

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Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists

Journal Of Clinical Periodontology ◽

10.1111/j.1600-051x.1993.tb00360.x ◽

1993 ◽

Vol 20 (4) ◽

pp. 286-293 ◽

Cited By ~ 85

Author(s):

Gaston N. King ◽

Robert Fullinfaw ◽

Thomas J. Higgins ◽

Rowan G. Walker ◽

David M. A. Francis ◽

...

Keyword(s):

Cyclosporin A ◽

Calcium Antagonists ◽

Renal Allograft ◽

Gingival Hyperplasia

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Cyclosporin-A Treatment in Steroid Nonresponsive Nephrotic Syndrome

Paediatrica Indonesiana ◽

10.14238/pi34.1-2.1994.1-7 ◽

2018 ◽

Vol 34 (1-2) ◽

pp. 1-7

Author(s):

IGN Wila Wirya ◽

Taralan Tambunan ◽

Husein Alatan

Keyword(s):

Nephrotic Syndrome ◽

Cyclosporin A ◽

Partial Remission ◽

Good Alternative ◽

Major Advance ◽

Gingival Hyperplasia ◽

Steroid Dependent ◽

Function Impairment ◽

Frequent Relapsers ◽

Total Remission

Fifteen patients with steroid nonresponsive nephrotic syndrome (NS) aged 4-16 years received oral cyclosporin-A (CyA) for 12 weeks. Nine of the patients were boys. Out of the 15 patients, 7 were frequent relapsers, 3 were steroid dependents, 4 were steroid resistants and one with toxic steroid. After 12 weeks of CyA treatment;, 6 patients showed complete remission, 7 showed partial remission, and 2 patients did not respond at all. Side effects observed were slight renal function impairment, gingival hyperplasia, and a hump on the breast; all disappeared gradually after stopping CyA. Patients with total remission experienced relapse 2 to 12 months after discontinuation of CyA, while patients with partial remission experienced relapse 2 weeks to 3 months after CyA was discontinued A tentative conclusion can be drawn that CyA is a good alternative in the treatment of idiopathic NS, especially in steroid dependent patients who are at risk of developing steroid toxicity. CyA represent a major advance in the treatment selected SN patients who have failed with the conventional modes of therapy.

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