Ovulation Induction in Patients with Polycystic Ovarian Syndrome (PCOS) & Hyperprolactinemia (HPRL): Efficacy of Letrozole (LE) Combined with Cabergoline (CE) in Comparison to (LE) Alone

ABSTRACT Introduction The polycystic ovary syndrome (PCOS) is the most common condition associated with chronic anovulation affecting 4 to 6% of reproductive age women. Aim To compare the effectiveness of laparoscopic ovarian drilling (LOD) for ovulation induction with gonadotropins in clomiphene-resistant PCOS in terms of ovulation, pregnancy, live birth, abortion, multiple pregnancies, and complication like ovarian hyperstimulation syndrome (OHSS). Setting and design A prospective hospital-based randomized trial. Materials and methods It was a prospective study, which was carried out from January 2012 to May 2015. Totally, 89 women were evaluated in the study, out of which 44 women were in gonadotropin group and 45 were in LOD group. Statistical analysis Standard statistical analysis was done and significance of difference in results was tested by chi-square test. Results Ovulation rate in gonadotropin group was 75.0% at 6 months, whereas in LOD group, it was 20% at 3 months and was increased up to 66.66% after addition of clomiphene citrate and gonadotropin. The primary outcome in terms of pregnancy in gonadotropin group was 45.45% after 6 cycles and in LOD group was 11.11% after 3 cycles and 40.00% after 6 cycles with supplementation of clomiphene citrate and gonadotropin. Conclusion The ongoing pregnancy rate from ovulation induction with LOD alone was significantly less but if supplemented by clomiphene citrate and gonadotropin, it seems equivalent to ovulation induction with gonadotropin, but the former procedure carries a lower risk of multiple pregnancies. How to cite this article Yadav P, Singh S, Singh R, Jain M, Awasthi S, Raj P. To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):336-340.

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Prevalence of gestational diabetes mellitus in polycystic ovarian syndrome (PCOS) patients pregnant after ovulation induction with gonadotrophins

Australian and New Zealand Journal of Obstetrics and Gynaecology ◽

10.1111/j.1479-828x.2000.tb03167.x ◽

2000 ◽

Vol 40 (1) ◽

pp. 54-58 ◽

Cited By ~ 33

Author(s):

Beverley Vollenhoven ◽

Suzanne Clark ◽

Gabor Kovacs ◽

Henry Burger ◽

David Healy

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Ovulation Induction ◽

Polycystic Ovarian Syndrome ◽

Ovarian Syndrome

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Clomiphene, Metformin, or Both for Infertility With Polycystic Ovarian Syndrome

50 Studies Every Obstetrician-Gynecologist Should Know ◽

10.1093/med/9780190947088.003.0044 ◽

2021 ◽

pp. 240-245

Author(s):

Tana Kim ◽

Zaraq Khan

Keyword(s):

Treatment Option ◽

Ovulation Induction ◽

Polycystic Ovarian Syndrome ◽

Randomized Study ◽

Induction Treatment ◽

Multiple Gestation ◽

Double Blind ◽

Subsequent Fertility ◽

Ovarian Syndrome ◽

Pharmacologic Therapies

The PPCOS trial examines and compares ovulation induction treatments for infertile women with a diagnosis of polycystic ovarian syndrome (PCOS). Both clomiphene and metformin are pharmacologic therapies that have been utilized to promote ovulation and subsequent fertility in women with PCOS. However, it is uncertain if clomiphene, metformin, or a combination of both should be the first-line ovulation induction treatment option for women with PCOS. This study examines fertility and pregnancy outcomes for PCOS women by performing a double-blind, randomized study utilizing 3 different study arms: clomiphene, metformin, and clomiphene plus metformin. This study not only reviews differences in ovulation, pregnancy loss, live birth, and multiple gestation rates between the 3 different study arms, but it also concludes which treatment option is superior for infertile PCOS women seeking treatment.

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