scholarly journals Myocardial Protection in Neonates and Infants: What have we Learnt? Where do we Go?

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Sachin Talwar ◽  
Vikas K. Keshri ◽  
Shiv K. Choudhary ◽  
Balram Airan
Keyword(s):  
Myocardial Protection ◽  
Neonates And Infants

Truncal valve repair in neonates and infants

2020 ◽  
Author(s):  
Phillip S. Naimo ◽  
Igor E. Konstantinov ◽  
Edward Buratto
Keyword(s):  
Valve Repair ◽  
Neonates And Infants

Results of aortic arch reconstruction in neonates and infants

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
L Ben Mime ◽  
M Emmel ◽  
N Sreeram ◽  
K Brockmeier ◽  
G Bennink ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Aortic Arch Reconstruction ◽  
Neonates And Infants ◽  
Arch Reconstruction

Flexible retractor system for neonates and infants

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
R von Wattenwyl ◽  
J Schöllhorn ◽  
F Beyersdorf
Keyword(s):  
Neonates And Infants

The new St Thomas' Hospital polarized cardioplegia: improved efficacy of myocardial protection in pigs on CPB

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
D. Santer ◽  
W. Dietl ◽  
K. Trescher ◽  
M. Kreibich ◽  
E. Dzilic ◽  
...  
Keyword(s):  
Myocardial Protection

Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

2015 ◽  
Vol 18 (4) ◽  
pp. 171 ◽  
Author(s):  
Tolga Demir ◽  
Mehmet Umit Ergenoglu ◽  
Hale Bolgi Demir ◽  
Nursen Tanrikulu ◽  
Mazlum Sahin ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Myocardial Protection ◽  
Troponin T ◽  
Artery Bypass ◽  
Control Group ◽  
Study Group ◽  
Cabg Surgery ◽  
Anti Inflammatory ◽  
Pump Coronary Artery Bypass

<strong>Background</strong>: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).<br /><strong>Methods</strong>: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. <br /><strong>Results</strong>: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: <br />P &lt; .001; T4: P &lt; .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group <br />(P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001).<br /><strong>Conclusions</strong>: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.<br /><br />

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