scholarly journals Synthesis of novel Schiff base derivatives of tacrine and investigation of their acetylcholinesterase inhibition potency

2019 ◽  
Vol 38 (1) ◽  
pp. 75 ◽  
Author(s):  
Elif Koyuncu ◽  
Ahmet Yaşar ◽  
Fatma Arslan ◽  
Nurşen Sari
Keyword(s):  
Schiff Base ◽  
Potent Inhibitor ◽  
Water Soluble ◽  
Acetylcholinesterase Inhibition ◽  
Ache Inhibitor ◽  
Schiff Base Derivatives ◽  
Ic50 Value ◽  
Ft Ir ◽  
Inhibition Potency ◽  
Derivatives Of

Investigation of acetylcholinesterase (AChE) inhibition potency of some new Schiff base derivatives of tacrine (9-amino-1,2,3,4-tetrahydroacridine) was reported in this paper. Novel Schiff base derivatives of tacrine (3a–g) have been synthesized, and they have been characterized by several methods (FT-IR, 1H-NMR, 13C-NMR, etc.). Then, inhibition effects on AChE by the synthesized compounds have been investigated by the spectrophotometric Ellman method. IC50, Ki, KM and Vmax values and inhibition types have been determined. It was seen that all compounds had the property of a water-soluble reversible AChE inhibitor. Structure 3a was found to be the most potent inhibitor, with the IC50 value of 22.1 ± 1.11  nM (tacrine's IC50 value was calculated as 34.1 nM).

scholarly journals Synthesis, Spectral and Microbial Studies of Some Novel Schiff Base Derivatives of 4-Methylpyridin-2-amine

2009 ◽  
Vol 6 (4) ◽  
pp. 1205-1210 ◽  
Author(s):  
J. J. Vora ◽  
S. B. Vasava ◽  
K. C. Parmar ◽  
S. K. Chauhan ◽  
S. S. Sharma
Keyword(s):  
Schiff Base ◽  
Antimicrobial Activities ◽  
Dilution Method ◽  
Mass Spectral ◽  
H Nmr ◽  
Schiff Base Derivatives ◽  
Ft Ir ◽  
Acid Catalyzed ◽  
Derivatives Of ◽  
Broth Dilution

Schiff base derivatives ofN-{(1E)-[3-(mono or di-substituted aryl)-1-phenyl-1H-pyrazol-4-yl]methylene{-4-methylpyridin-2-amine were synthesized by the acid catalyzed condensation of 3-(mono- or di- substituted aryl)-1-phenyl-1H-pyrazole-4-carbaldehyde derivatives with 4-methylpyridin-2-amine. Schiff base derivatives were characterized by FT-IR,1H-NMR, Mass spectral analysis and elemental analysis. All the synthesized compounds have been screened for their antimicrobial activities by using broth dilution method.

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

2014 ◽  
Vol 74 ◽  
pp. 742-750 ◽  
Author(s):  
Chengyuan Liang ◽  
Juan Xia ◽  
Dong Lei ◽  
Xiang Li ◽  
Qizheng Yao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antitumor Activity ◽  
Schiff Base Derivatives ◽  
In Vivo Antitumor Activity ◽  
Derivatives Of

New Helical Zinc Complexes with Schiff Base Derivatives of β-Diketonates or β-Keto Esters and Ethylenediamine

2009 ◽  
Vol 2009 (23) ◽  
pp. 3467-3474 ◽  
Author(s):  
Oxana Kotova ◽  
Sergey Semenov ◽  
Svetlana Eliseeva ◽  
Sergey Troyanov ◽  
Konstantin Lyssenko ◽  
...  
Keyword(s):  
Schiff Base ◽  
Zinc Complexes ◽  
Keto Esters ◽  
Schiff Base Derivatives ◽  
Derivatives Of

Synthesis, Crystal Structures and DFT Calculations of Two Schiff Base Derivatives of (2-Amino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methanone

2015 ◽  
Vol 45 (4) ◽  
pp. 193-201 ◽  
Author(s):  
Manpreet Kaur ◽  
Jerry P. Jasinski ◽  
Brian J. Anderson ◽  
Hemmige S. Yathirajan ◽  
K. Byrappa
Keyword(s):  
Schiff Base ◽  
Dft Calculations ◽  
Crystal Structures ◽  
Schiff Base Derivatives ◽  
Derivatives Of

scholarly journals Synthesis, Antimicrobial Screening, Homology Modeling, and Molecular Docking Studies of a New Series of Schiff Base Derivatives as Prospective Fungal Inhibitor Candidates

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3250 ◽  
Author(s):  
Yahya Toubi ◽  
Farid Abrigach ◽  
Smaail Radi ◽  
Faiza Souna ◽  
Abdelkader Hakkou ◽  
...  
Keyword(s):  
Schiff Base ◽  
Homology Modeling ◽  
Condensation Reaction ◽  
Docking Studies ◽  
Antifungal Effect ◽  
1H And 13C Nmr ◽  
Schiff Base Derivatives ◽  
Ft Ir ◽  
Antibacterial And Antifungal

Twelve new Schiff base derivatives have been prepared by the condensation reaction of different amino substituted compounds (aniline, pyridin-2-amine, o-toluidine, 2-nitrobenzenamine, 4-aminophenol, and 3-aminopropanol) and substituted aldehydes such as nicotinaldehyde, o,m,p-nitrobenzaldehyde, and picolinaldehyde in ethanol using acetic acid as a catalyst. The envisaged structures of the all the synthesized ligands have been confirmed on the basis of their spectral analysis FT-IR, mass spectroscopy, 1H- and 13C-NMR. In vitro screening of their antibacterial and antifungal potential against Escherichia coli bacterium and Fusarium oxysporum f.sp albedinis (F.o.a) fungus, respectively, revealed that all the ligands showed no significant antibacterial activity, whereas most of them displayed good antifungal activity. Homology modeling and docking analysis were performed to explain the antifungal effect of the most and least active compound against two F.o.a fungus proteins.

Schiff base derivatives of chromium carbonyl

1985 ◽  
Vol 98 (1) ◽  
pp. 19-23 ◽  
Author(s):  
S.C. Tripathi ◽  
S.C. Srivastava ◽  
A.K. Shrimal ◽  
O.P. Singh
Keyword(s):  
Schiff Base ◽  
Schiff Base Derivatives ◽  
Chromium Carbonyl ◽  
Derivatives Of

Schiff base derivatives of lanthanons

1975 ◽  
Vol 106 (1) ◽  
pp. 261-270 ◽  
Author(s):  
S. K. Agarwal ◽  
Jai P. Tandon
Keyword(s):  
Schiff Base ◽  
Schiff Base Derivatives ◽  
Derivatives Of
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