scholarly journals Connective Tissue Growth Factor in Normal and Pathological Processes

2020 ◽  
Vol 10 (4) ◽  
pp. 254-261
Author(s):  
S. V. Topolyanskaya
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Potential Role ◽  
Tissue Growth ◽  
Matrix Proteins ◽  
Cellular Functions ◽  
Different Types ◽  
Oncological Diseases

Modern concepts about the role of connective tissue growth factor in various physiological and pathological processes are described in the review. Connective tissue growth factor regulates a variety of cellular functions, including proliferation, migration, adhesion, differentiation and synthesis of extracellular matrix proteins in cells of different types. This factor is also involved in more complex biological processes of angiogenesis, chondrogenesis, wound healing, fibrosis and oncogenesis. Increased expression of connective tissue growth factor is observed in different cardiovascular and oncological diseases. Potential role of this growth factor in regulation of cellular senescence and aging processes is also discussed.

scholarly journals The pathogenic role of connective tissue growth factor in osteoarthritis

2019 ◽  
Vol 39 (7) ◽  
Author(s):  
Min Tu ◽  
Yao Yao ◽  
Feng Hua Qiao ◽  
Li Wang
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Therapeutic Target ◽  
Surface Damage ◽  
Nuclear Factor Κb ◽  
Cartilage Degradation ◽  
Tissue Growth ◽  
Cartilage Homeostasis

Abstract Osteoarthritis (OA) is the most common form of arthritis, and connective tissue growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage surface damage. CTGF is present in osteophytes of late stage OA. In the present study, we have reviewed association of CTGF in the development and progression of OA and the potential effects of CTGF as a therapeutic agent for the treatment of OA. We have reviewed the recent articles on CTGF and OA in databases like PubMed, google scholar, and SCOPUS and collected the information for the articles. CTGF is usually up-regulated in synovial fluid of OA that stimulates the production of inflammatory cytokines. CTGF also activates nuclear factor-κB, increases the production of chemokines and cytokines, and up-regulates matrix metalloproteinases-3 (MMP-3) that in turn leads to the reduction in proteoglycan contents in joint cartilage. Consequently, cartilage homeostasis is imbalanced that might contribute to the pathogenesis of OA by developing synovial inflammation and cartilage degradation. CTGF might serve as a useful biomarker for the prognosis and treatment of OA, and recent studies have taken attempt to use CTGF as therapeutic target of OA. However, more investigations with clinical trials are necessary to validate the possibility of use of CTGF as a biomarker in OA diagnosis and therapeutic target for OA treatment.

scholarly journals Role of Connective Tissue Growth Factor in the Retinal Vasculature during Development and Ischemia

2011 ◽  
Vol 52 (12) ◽  
pp. 8701 ◽  
Author(s):  
Liya Pi ◽  
Huiming Xia ◽  
Jianwen Liu ◽  
Anitha K. Shenoy ◽  
William W. Hauswirth ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Retinal Vasculature

EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR AND ITS POTENTIAL ROLE IN CHOROIDAL NEOVASCULARIZATION

Retina ◽  
2005 ◽  
Vol 25 (7) ◽  
pp. 911-918 ◽  
Author(s):  
DAISUKE WATANABE ◽  
HITOSHI TAKAGI ◽  
KIYOSHI SUZUMA ◽  
HIDEYASU OH ◽  
HIROKAZU OHASHI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Choroidal Neovascularization ◽  
Connective Tissue Growth Factor ◽  
Potential Role ◽  
Tissue Growth
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