Artificial Neural Network Analysis of Geo Database in Diagnosing Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
zhoujing zhang ◽  
di xu ◽  
Ozioma Akakuru ◽  
wenjing xu ◽  
yewei zhang
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Artificial Neural Network ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Network Models ◽  
Papillary Thyroid ◽  
Neural Network Models ◽  
Artificial Neural ◽  
Artificial Neural Network Models

The diagnosis of papillary thyroid carcinoma has always been a concerned and challenging issue and it is very important and meaningful to have a definite diagnosis before the operation. In this study, we tried to use an artificial intelligence algorithm instead of medical statistics to analyze the genetic fingerprint from gene chip results to identify papillary thyroid carcinoma. We trained 20 artificial neural network models with differential genes and other important genes related to the cell metabolic cycle as the list of input features, and apply them to the diagnosis of papillary thyroid cancer in the independent validation data set. The results showed that when we used the DEGs and all genes lists as input features the models got the best diagnostic performance with AUC=98.97% and 99.37% and the accuracy were both 96%. This study revealed that the proposed artificial neural network models constructed with genetic fingerprints could achieve a prediction of papillary thyroid carcinoma. Such models can support clinicians to make more accurate clinical diagnoses. At the same time, it provides a novel idea for the application of artificial intelligence in clinical medicine.

Automatic Electrocardiographic Analysis Using Artificial Neural Network Models

2011 ◽  
Vol 403-408 ◽  
pp. 3587-3593
Author(s):  
T.V.K. Hanumantha Rao ◽  
Saurabh Mishra ◽  
Sudhir Kumar Singh
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Radial Basis Function ◽  
Basis Function ◽  
Network Models ◽  
Neural Network Models ◽  
Radial Basis ◽  
Artificial Neural ◽  
Artificial Neural Network Models ◽  
Self Organizing

In this paper, the artificial neural network method was used for Electrocardiogram (ECG) pattern analysis. The analysis of the ECG can benefit from the wide availability of computing technology as far as features and performances as well. This paper presents some results achieved by carrying out the classification tasks by integrating the most common features of ECG analysis. Four types of ECG patterns were chosen from the MIT-BIH database to be recognized, including normal sinus rhythm, long term atrial fibrillation, sudden cardiac death and congestive heart failure. The R-R interval features were performed as the characteristic representation of the original ECG signals to be fed into the neural network models. Two types of artificial neural network models, SOM (Self- Organizing maps) and RBF (Radial Basis Function) networks were separately trained and tested for ECG pattern recognition and experimental results of the different models have been compared. The trade-off between the time consuming training of artificial neural networks and their performance is also explored. The Radial Basis Function network exhibited the best performance and reached an overall accuracy of 93% and the Kohonen Self- Organizing map network reached an overall accuracy of 87.5%.

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