Hyperbaric oxygen reduces edema and necrosis of skeletal muscle in compartment syndromes associated with hemorrhagic hypotension.

1986 ◽  
Vol 68 (8) ◽  
pp. 1218-1224 ◽  
Author(s):  
M J Skyhar ◽  
A R Hargens ◽  
M B Strauss ◽  
D H Gershuni ◽  
G B Hart ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hyperbaric Oxygen ◽  
Compartment Syndromes ◽  
Hemorrhagic Hypotension

Reduction of skeletal muscle necrosis using intermittent hyperbaric oxygen in a model compartment syndrome.

1983 ◽  
Vol 65 (5) ◽  
pp. 656-662 ◽  
Author(s):  
M B Strauss ◽  
A R Hargens ◽  
D H Gershuni ◽  
D A Greenberg ◽  
A G Crenshaw ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Compartment Syndrome ◽  
Hyperbaric Oxygen ◽  
Muscle Necrosis

Morphologic Analysis of the Microcirculation During Reperfusion of Ischemic Skeletal Muscle and the Effect of Hyperbaric Oxygen

1993 ◽  
Vol 91 (6) ◽  
pp. 1110-1123 ◽  
Author(s):  
William A. Zamboni ◽  
Allan C. Roth ◽  
Robert C. Russell ◽  
Brent Graham ◽  
Hans Suchy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hyperbaric Oxygen ◽  
Morphologic Analysis

Enhancement of satellite cell differentiation and functional recovery in injured skeletal muscle by hyperbaric oxygen treatment

2014 ◽  
Vol 116 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Masaki Horie ◽  
Mitsuhiro Enomoto ◽  
Manabu Shimoda ◽  
Atsushi Okawa ◽  
Shumpei Miyakawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Hyperbaric Oxygen ◽  
Functional Recovery ◽  
Muscle Regeneration ◽  
Muscle Injury ◽  
Muscle Fibers ◽  
Maximum Force ◽  
Pcr Analysis ◽  
Regulatory Factor

Recently, the use of hyperbaric oxygen (HBO) treatments by elite athletes to accelerate recovery from muscle injuries has become increasingly popular. However, the mechanism of promoting muscle regeneration under HBO conditions has not yet been defined. In this study, we investigated whether HBO treatments promoted muscle regeneration and modulated muscle regulatory factor expression in a rat skeletal muscle injury model. Muscle injury was induced by injecting cardiotoxin (CTX) into the tibialis anterior (TA) muscles. As the HBO treatment, rats were placed in an animal chamber with 100% oxygen under 2.5 atmospheres absolute for 2 h/day, 5 days/wk for 2 wk. We then performed histological analyses, measured the maximum force-producing capacity of the regenerating muscle fibers, and performed quantitative RT-PCR analysis of muscle regulatory factor mRNAs. The cross-sectional areas and maximum force-producing capacity of the regenerating muscle fibers were increased by HBO treatment after injury. The mRNA expression of MyoD, myogenin, and IGF-1 increased significantly in the HBO group at 3 and 5 days after injury. The number of Pax7+/MyoD+, Pax7−/MyoD+, and Pax7+/BrdU+-positive nuclei was increased by HBO treatment. In this study, we demonstrated that HBO treatment accelerated satellite cell proliferation and myofiber maturation in rat muscle that was injured by a CTX injection. These results suggest that HBO treatment accelerates healing and functional recovery after muscle injury.

Sign in / Sign up

Export Citation Format

Share Document