Pediatric Tenosynovial Giant Cell Tumor of the Flexor Hallucis Longus Tendon Sheath

2020 ◽  
Vol 10 (2) ◽  
pp. e0519-e0519
Author(s):  
Richard D. Williams ◽  
M. Wesley Honeycutt ◽  
Elizabeth A. Manci ◽  
Prasit Nimityongskul
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Flexor Hallucis Longus ◽  
Longus Tendon ◽  
Tenosynovial Giant Cell Tumor

Giant Cell Tumor of the Flexor Hallucis Longus Tendon Sheath

2011 ◽  
Vol 101 (2) ◽  
pp. 187-189 ◽  
Author(s):  
Jeff Findling ◽  
Natalie K. LaScola ◽  
Thomas W. Groner
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Flexor Hallucis Longus ◽  
Resonance Imaging ◽  
Longus Tendon ◽  
Complete Surgical Excision

Giant cell tumor of tendon sheath is infrequently documented in the foot and even less near the ankle. This case report involves such a tumor of the flexor hallucis longus tendon presenting at the posterior ankle. Diagnosis was aided by magnetic resonance imaging, and treatment consisted of complete surgical excision. Pathologic examination verified the diagnosis of giant cell tumor of tendon sheath, and follow-up magnetic resonance imaging revealed no remnants or recurrence of tumor 1 year after surgery. (J Am Podiatr Med Assoc 101(2): 187–189, 2011)

Atypical Tenosynovial Giant Cell Tumor of the Extensor Hallucis Longus Tendon

2006 ◽  
Vol 96 (4) ◽  
pp. 359-361 ◽  
Author(s):  
Keiichi Muramatsu ◽  
Takatomo Mine ◽  
Kazuhiko Ichihara
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Resonance Imaging ◽  
Characteristic Appearance ◽  
Longus Tendon ◽  
Tenosynovial Giant Cell Tumor ◽  
Extensor Hallucis Longus ◽  
Multiple Nodules

We present a case of atypical giant cell tumor of the tendon sheath originating from the extensor hallucis longus tendon. The tumor contained multiple nodules and overlay the tendon 16 cm. Magnetic resonance imaging was the most useful preoperative investigation and showed the characteristic appearance of giant cell tumor of the tendon sheath, thus allowing local excision to be planned and executed. We discuss how local recurrence of this tumor could be prevented. (J Am Podiatr Med Assoc 96(4): 359–361, 2006)

Giant Cell Tumor of the Tendon Sheath Around the Foot and Ankle

2015 ◽  
Vol 105 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Gauresh Vargaonkar ◽  
Vikramadittya Singh ◽  
Sumit Arora ◽  
Abhishek Kashyap ◽  
Vikas Gupta ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Surgical Excision ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Flexor Hallucis Longus ◽  
Rare Clinical Entity ◽  
Foot And Ankle ◽  
Peroneus Brevis

The foot and ankle are rare sites of involvement for giant cell tumor of tendon sheath. We present three rare cases of giant cell tumor of tendon sheath arising from the tendon sheaths of the flexor hallucis longus, peroneus brevis, and extensor hallucis brevis tendons, along with a literature review of such cases in the foot and ankle region. All of the patients were treated with surgical excision of the mass and were asymptomatic after minimum follow-up of 18 months. Giant cell tumor of tendon sheath involving the foot and ankle region is a rare clinical entity, and good results can be expected after surgical excision.

scholarly journals ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT)

2020 ◽  
Vol 16 (25) ◽  
pp. 1875-1878 ◽  
Author(s):  
William Tap
Keyword(s):  
Side Effects ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Liver Function Tests ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Hair Color ◽  
Plain Language ◽  
Clinical Trial Registration ◽  
Tenosynovial Giant Cell Tumor

Pexidartinib is the first approved medication in the USA for people with tenosynovial giant cell tumor (TGCT). The drug was approved based on the ENLIVEN study, which looked at pexidartinib (brand name, Turalio™), a medication taken by mouth (orally) for people with TGCT (also known as giant cell tumor of the tendon sheath [GCTTS] and pigmented villonodular synovitis [PVNS]) who are not able to have surgery because of the location and/or the size of the tumor. The study showed that pexidartinib is effective in treating people with TGCT because it shrunk the size of their tumors and improved their symptoms and their ability to function. In general, people treated with pexidartinib had side effects that were mostly mild that went away after treatment with pexidartinib was stopped. The most common side effects were hair color changes and tiredness (fatigue). Pexidartinib was also associated with liver problems (or hepatotoxicity), which started within the first 2 months of treatment. Due to the risk of liver problems, which may be severe and potentially life threatening, the researchers closely monitored participants’ blood liver function tests before, during, and after participants in the study took pexidartinib. To read the full Plain Language Summary of this article, click on the View Article button above and download the PDF. Clinical Trial Registration: NCT02371369 ( ClinicalTrials.gov )

Localized Tenosynovial Giant Cell Tumor of Tendon Sheath

2000 ◽  
Vol 44 (3) ◽  
pp. 463-466 ◽  
Author(s):  
Monisha Choudhury ◽  
Renu Jain ◽  
Anita Nangia ◽  
K.B. Logani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Tenosynovial Giant Cell Tumor

scholarly journals Management of a Huge Tenosynovial Giant Cell Tumor of the Wrist

2021 ◽  
Author(s):  
Woo Jong Kim ◽  
Sang Mi Lee ◽  
Byungsung Kim ◽  
Jae-Hwi Nho ◽  
Jun Bum Kim ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rare Case ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Benign Neoplasms ◽  
Diffuse Type ◽  
Giant Cell Tumors ◽  
Tenosynovial Giant Cell Tumor

Tenosynovial giant cell tumors (TGCTs) are typically benign neoplasms of the joint, bursa, and tendon sheath. Usually, TGCT presents as a small localized tumor on the hand and wrist. The diffuse-type TGCT is more aggressive and mainly affects large joints such as knees, hips, ankles, and elbows. Diffuse-type TGCT of small joints is rare. To our knowledge, this is a very rare case of a huge diffuse-type TGCT on the wrist. We report a huge TGCT, which grew gradually over 10 years.

scholarly journals Tenosynovial giant cell tumor of the tendon sheat

2021 ◽  
Vol 24 (2) ◽  
pp. 100-107
Author(s):  
M. A. Khodorkovskiy
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Kinase Inhibitors ◽  
Benign Neoplasm ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Adjuvant Radiation ◽  
Tenosynovial Giant Cell Tumor ◽  
Optical Magnification ◽  
Plastic Reconstructive Surgery

The review article outlines modern aspects of the nomenclature, etiopathogenesis, diagnosis and treatment of tenosynovial giant cell tumor of the tendon sheath. This is the second most common benign neoplasm of the hand. Non-radical surgical treatment of this disease leads to a large number of recurrence. To avoid tumor recurrence, surgeon must to have the basics of plastic reconstructive surgery, use delicate instruments and optical magnification. In some cases, adjuvant radiation therapy and administration of tyrosine kinase inhibitors may be required.

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