scholarly journals Seronegative Miller–Fisher syndrome with bulbar palsy – reference to the spectrum of autoimmune neuropathies with the presence of antiganglioside antibodies. A case report

2018 ◽  
Vol 64 (1) ◽  
Author(s):  
Agnieszka Meller ◽  
Monika Gołąb-Janowska ◽  
Zofia Osuch ◽  
Michał Maj ◽  
Przemysław Nowacki

ABSTRAKTWstęp: Zespół Millera–Fishera jest rzadkim wariantem ostrej zapalnej poliradikulopatii demielinizacyjnej.Opis przypadku: Przedstawiono przypadek rzadkiej klinicznej manifestacji zespołu Millera–Fishera pod postacią dyzartrycznej mowy oraz dysfagii spowodowanej porażeniem podniebienia miękkiego. Objawy były poprzedzone problemami z równowagą, zaburzeniami widzenia oraz drętwieniem kończyn górnych. W surowicy krwi stwierdzono ujemne przeciwciała anty-GQ1b.W leczeniu zastosowano 5 cykli plazmaferezy. W 16. dniu hospitalizacji odnotowano zmniejszenie ataksji, a także poprawę w zakresie ruchomości gałek ocznych oraz chodu. Po 8 tygodniach od początku wystąpienia objawów choroby uzyskano całkowite ustąpienie deficytu neurologicznego.

Author(s):  
A. Peral Quirós ◽  
F. Acebrón ◽  
M. del Carmen Blanco Valero ◽  
F. Labella Álvarez

2021 ◽  
Vol 75 (3) ◽  
pp. 234
Author(s):  
Maja Ravlic ◽  
Lana Knezevic ◽  
Iva Krolo ◽  
Jelena Herman

2018 ◽  
Vol 58 (5) ◽  
pp. 746-749
Author(s):  
David Moreno-Ajona ◽  
Pablo Irimia ◽  
Marta Fernández-Matarrubia

2020 ◽  
Vol 13 (8) ◽  
pp. e236419 ◽  
Author(s):  
Amanda Ray

Beyond the typical respiratory symptoms and fever associated with severe acute respiratory syndrome, we may still have much to learn about other manifestations of the novel SARS-CoV-2 infection. A patient presented with Guillain-Barré syndrome in China with a concurrent SARS-CoV-2 infection. The following case report looks at a patient presenting with the rare Miller Fisher syndrome, a variant of Guillain-Barré while also testing positive for COVID-19.


2019 ◽  
Vol 48 (3) ◽  
pp. 030006051986749
Author(s):  
Yu-Ming Liu ◽  
Yan-Li Chen ◽  
Yan-Hua Deng ◽  
Yan-Ling Liang ◽  
Wei Li ◽  
...  

Miller Fisher syndrome (MFS), a variant of Guillain–Barré syndrome, is characterized by ataxia, areflexia and ophthalmoplegia. This case report describes a 40-year old male that presented with a 3-day history of unsteady walking and numbness on both hands, and a 2-day history of seeing double images and unclear articulation. Lumbar puncture revealed an opening pressure of 260 mm H2O. Plasma serology was positive for anti-ganglioside M1-immunoglobulin M (anti-GM1-IgM) antibodies and negative for anti-ganglioside Q1b (anti-GQ1b) antibodies. The patient was diagnosed with MFS based on the clinical course and neurophysiological findings. On the 4th day of treatment with intravenous immunoglobulin (IVIG), his ataxia and unsteady walking improved, but his bilateral eyeballs were fixed, and over the next few days he developed bilateral peripheral facial paralysis. After 5 days of IVIG treatment, methylprednisolone treatment was offered and the patient's symptoms gradually improved. Early intracranial hypertension and delayed facial nerve palsy may be atypical presentations of MFS. Anti-GM1-IgM antibodies may be the causative antibodies for MFS. If the IVIG therapy does not stop the progression of the disease, the addition of corticosteroid therapy may be effective. However, the relationship between IgM type, anti-GM1 antibody and MFS remains unclear and requires further research.


2012 ◽  
Vol 29 (6) ◽  
pp. 105-110 ◽  
Author(s):  
Seung Min Lee ◽  
Young Seung Ji ◽  
Chang Woo Lee ◽  
Ju Hyun Jeon ◽  
Jung Ho Kim ◽  
...  

2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Jonathan Smith ◽  
Lucy Clarke ◽  
Philip Severn ◽  
Robert Boyce

2021 ◽  
Vol 429 ◽  
pp. 119818
Author(s):  
Giuseppina Barbella ◽  
Simone Tonietti ◽  
Massimo Suardelli ◽  
Fabio Frediani

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