scholarly journals Association between peripheral blood/bronchoalveolar lavage eosinophilia and significant oxygen requirements in patients with acute eosinophilic pneumonia

2020 ◽  
Author(s):  
Joon Young Choi ◽  
Jeong Uk Lim ◽  
Ho Jung Jeong ◽  
Ji Eun Lee ◽  
Chin Kook Rhee
Keyword(s):  
Logistic Regression ◽  
Bronchoalveolar Lavage ◽  
Roc Curve ◽  
Oxygen Supply ◽  
Eosinophilic Pneumonia ◽  
Blood Eosinophil ◽  
Multiple Logistic Regression ◽  
Acute Eosinophilic Pneumonia ◽  
Correlation Analyses ◽  
Oxygen Requirements

Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP). Methods We retrospectively reviewed the medical records of patients with AEP treated at the Armed Forces Capital Hospital between May 2012 and May 2017. We used correlation analyses to assess the association between PEC/BEP and clinical outcomes in AEP patients. Receiver operating characteristic (ROC) curve analyses were used to calculate the cut-off value for BEP that categorised patients requiring a significant oxygen supply. The BAL/blood eosinophil (BBE) score was introduced to stratify patients with peripheral eosinophilia and elevated BEP. Clinical characteristics and outcomes were compared between the different groups. Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). Results Among the 338 patients, 99.7% were male, and their mean age was 20.4 ± 1.4 years. Only 0.6% of patients were never smokers and the mean number of smoking days was 26.2 ± 25.4. Correlation analyses revealed that both the PaO2/FiO2 ratio and duration of oxygen supply were associated with BEP. ROC curve analyses indicated a cut-off level of 41.5%. Patients with a high BBE score had favourable outcomes in terms of hypoxemia, hospital days, intensive care unit admission, oxygen supply days, and steroid treatment days. Multiple logistic regression revealed that BEP and BBE score tended to be associated with significant oxygen requirements. Conclusions In this study, we revealed that both peripheral and BAL eosinophilia is associated with favourable outcomes in AEP patients.

scholarly journals Association between peripheral blood/bronchoalveolar lavage eosinophilia and significant oxygen requirements in patients with acute eosinophilic pneumonia

2019 ◽  
Author(s):  
Joon Young Choi ◽  
Jeong Uk Lim ◽  
Ho Jung Jeong ◽  
Ji Eun Lee ◽  
Chin Kook Rhee
Keyword(s):  
Logistic Regression ◽  
Bronchoalveolar Lavage ◽  
Roc Curve ◽  
Oxygen Supply ◽  
Eosinophilic Pneumonia ◽  
Blood Eosinophil ◽  
Multiple Logistic Regression ◽  
Acute Eosinophilic Pneumonia ◽  
Correlation Analyses ◽  
Oxygen Requirements

Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP). Methods We retrospectively reviewed the medical records of patients with AEP treated at the Armed Forces Capital Hospital between May 2012 and May 2017. We used correlation analyses to assess the association between PEC/BEP and clinical outcomes in AEP patients. Receiver operating characteristic (ROC) curve analyses were used to calculate the cut-off value for BEP that categorised patients requiring a significant oxygen supply. The BAL/blood eosinophil (BBE) score was introduced to stratify patients with peripheral eosinophilia and elevated BEP. Clinical characteristics and outcomes were compared between the different groups. Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). Results Among the 338 patients, 99.7% were male, and their mean age was 20.4 ± 1.4 years. Only 0.6% of patients were never smokers and the mean number of smoking days was 26.2 ± 25.4. Correlation analyses revealed that both the PaO2/FiO2 ratio and duration of oxygen supply were associated with BEP. ROC curve analyses indicated a cut-off level of 41.5%. Patients with a high BBE score had favourable outcomes in terms of hypoxemia, hospital days, intensive care unit admission, oxygen supply days, and steroid treatment days. Multiple logistic regression revealed that BEP and BBE score tended to be associated with significant oxygen requirements. Conclusions In this study, we revealed that both peripheral and BAL eosinophilia is associated with favourable outcomes in AEP patients.

scholarly journals Association between peripheral blood/bronchoalveolar lavage eosinophilia and significant oxygen requirements in patients with acute eosinophilic pneumonia

2020 ◽  
Author(s):  
Joon Young Choi ◽  
Jeong Uk Lim ◽  
Ho Jung Jeong ◽  
Ji Eun Lee ◽  
Chin Kook Rhee
Keyword(s):  
Logistic Regression ◽  
Bronchoalveolar Lavage ◽  
Roc Curve ◽  
Oxygen Supply ◽  
Eosinophilic Pneumonia ◽  
Blood Eosinophil ◽  
Multiple Logistic Regression ◽  
Acute Eosinophilic Pneumonia ◽  
Correlation Analyses ◽  
Oxygen Requirements

Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP). Methods We retrospectively reviewed the medical records of patients with AEP treated at the Armed Forces Capital Hospital between May 2012 and May 2017. We used correlation analyses to assess the association between PEC/BEP and clinical outcomes in AEP patients. Receiver operating characteristic (ROC) curve analyses were used to calculate the cut-off value for BEP that categorised patients requiring a significant oxygen supply. The BAL/blood eosinophil (BBE) score was introduced to stratify patients with peripheral eosinophilia and elevated BEP. Clinical characteristics and outcomes were compared between the different groups. Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). Results Among the 338 patients, 99.7% were male, and their mean age was 20.4 ± 1.4 years. Only 0.6% of patients were never smokers and the mean number of smoking days was 26.2 ± 25.4. Correlation analyses revealed that both the PaO2/FiO2 ratio and duration of oxygen supply were associated with BEP. ROC curve analyses indicated a cut-off level of 41.5%. Patients with a high BBE score had favourable outcomes in terms of hypoxemia, hospital days, intensive care unit admission, oxygen supply days, and steroid treatment days. Multiple logistic regression revealed that BEP and BBE score tended to be associated with significant oxygen requirements. Conclusions In this study, we revealed that both peripheral and BAL eosinophilia is associated with favourable outcomes in AEP patients.

scholarly journals Association between peripheral blood/bronchoalveolar lavage eosinophilia and significant oxygen requirements in patients with acute eosinophilic pneumonia

2020 ◽  
Author(s):  
Joon Young Choi ◽  
Jeong Uk Lim ◽  
Ho Jung Jeong ◽  
Ji Eun Lee ◽  
Chin Kook Rhee
Keyword(s):  
Logistic Regression ◽  
Bronchoalveolar Lavage ◽  
Roc Curve ◽  
Oxygen Supply ◽  
Eosinophilic Pneumonia ◽  
Blood Eosinophil ◽  
Multiple Logistic Regression ◽  
Acute Eosinophilic Pneumonia ◽  
Correlation Analyses ◽  
Oxygen Requirements

Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP). Methods We retrospectively reviewed the medical records of patients with AEP treated at the Armed Forces Capital Hospital between May 2012 and May 2017. We used correlation analyses to assess the association between PEC/BEP and clinical outcomes in AEP patients. Receiver operating characteristic (ROC) curve analyses were used to calculate the cut-off value for BEP that categorised patients requiring a significant oxygen supply. The BAL/blood eosinophil (BBE) score was introduced to stratify patients with peripheral eosinophilia and elevated BEP. Clinical characteristics and outcomes were compared between the different groups. Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). Results Among the 338 patients, 99.7% were male, and their mean age was 20.4 ± 1.4 years. Only 0.6% of patients were never smokers and the mean number of smoking days was 26.2 ± 25.4. Correlation analyses revealed that both the PaO2/FiO2 ratio and duration of oxygen supply were associated with BEP. ROC curve analyses indicated a cut-off level of 41.5%. Patients with a high BBE score had favourable outcomes in terms of hypoxemia, hospital days, intensive care unit admission, oxygen supply days, and steroid treatment days. Multiple logistic regression revealed that BEP and BBE score tended to be associated with significant oxygen requirements. Conclusions In this study, we revealed that both peripheral and BAL eosinophilia is associated with favourable outcomes in AEP patients.

scholarly journals Acute Eosinophilic Pneumonia Secondary to Menthol Cigarette Use: A Rare Phenomenon With a Review of Literature

2020 ◽  
Vol 8 ◽  
pp. 232470962092597
Author(s):  
Prateek Suresh Harne ◽  
Suman Rao ◽  
Muhammad Malik ◽  
Zachary Shepherd
Keyword(s):  
Respiratory Failure ◽  
Bronchoalveolar Lavage ◽  
Eosinophilic Pneumonia ◽  
Optimum Dose ◽  
Cigarette Use ◽  
Shortness Of Breath ◽  
Menthol Cigarette ◽  
Length Of Treatment ◽  
Acute Eosinophilic Pneumonia

Idiopathic acute eosinophilic pneumonia (AEP) is a very rare disease with fewer than 200 cases reported. It has been hypothesized to be a hypersensitivity reaction to an unidentified antigen. The clinical presentation typically involves fever, nonproductive cough, shortness of breath, and bibasilar inspiratory crackles within the first week of antigen exposure. Chest imaging usually reveals bilateral reticular and/or ground-glass opacities. Bronchoalveolar lavage demonstrates >25% eosinophils. Corticosteroids are the mainstay of treatment with good results; however, optimum dose and length of treatment are unclear. We present a case of a 31-year-old male who presented with 2 days of shortness of breath, cough, pleuritic chest pain, fevers, chills, nausea, and poor appetite in the setting of initiation of menthol-flavored cigarettes 2 weeks before presentation. He rapidly progressed to respiratory failure requiring intubation despite broad antibiotic coverage. His course was complicated by severe acute respiratory distress syndrome, circulatory shock, and renal failure. He underwent bronchoalveolar lavage testing that revealed 60% eosinophils. He was treated with steroids and was subsequently extubated and discharged. Eosinophilic counts in the blood peaked on the 10th day of admission to 34%. One week later, the patient was completely free of symptoms. The initiation of menthol cigarette use in this patient is the likely reason for ensuing acute eosinophilic pneumonia, hence adding to the sporadic reports on the role of menthol-flavored cigarettes. This case emphasizes a greater reliance on risk factors, as opposed to eosinophilic markers, for the diagnosis and treatment of acute eosinophilic pneumonia to prevent subsequent respiratory failure and intubation in such patients.

scholarly journals IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia.

1995 ◽  
Vol 34 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Shinji YAMAGUCHI ◽  
Yoshio OKUBO ◽  
Mahboob HOSSAIN ◽  
Keisaku FUJIMOTO ◽  
Takayuki HONDA ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Peripheral Blood ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Eosinophilic Pneumonia ◽  
Acute Eosinophilic Pneumonia

Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia

1996 ◽  
Vol 97 (6) ◽  
pp. 1366-1374 ◽  
Author(s):  
James N. Allen ◽  
Zhiming Liao ◽  
Mark D. Wewers ◽  
Elizabeth A. Altenberger ◽  
Sherri A. Moore ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Receptor Antagonist ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Eosinophilic Pneumonia ◽  
Acute Eosinophilic Pneumonia

scholarly journals Predictors of Undiagnosed Diabetes among Middle-Aged and Seniors in China: Application of Andersen’s Behavioral Model

2021 ◽  
Vol 18 (16) ◽  
pp. 8396
Author(s):  
Chaozhou Mou ◽  
Minlan Xu ◽  
Juncheng Lyu
Keyword(s):  
Logistic Regression ◽  
Health Service ◽  
Regression Model ◽  
Roc Curve ◽  
Behavioral Model ◽  
Undiagnosed Diabetes ◽  
Multiple Logistic Regression ◽  
Andersen’S Behavioral Model ◽  
Andersen Model ◽  
Geographical Regions

Undiagnosed diabetes is a threat to public health. This study aims to identify potential variables related to undiagnosed diabetes using Andersen’s behavioral model. Baseline data including blood test data from the China Health and Retirement Longitudinal Study (CHARLS) were adopted. First, we constructed health service related variables based on Andersen model. Second, univariate analysis and multiple logistic regression were used to analyze the relations of variables to undiagnosed diabetes. The strength of relationships was presented by odds ratios (ORs) and 95% confidence intervals (CIs). Finally, the prediction of multiple logistic regression model was assessed using the Receiver Operating Characteristic (ROC) curve and the area under the ROC curve (AUC). According to diagnosis standards, 1234 respondents had diabetes, among which 560 were undiagnosed and 674 were previously diagnosed. Further analysis showed that the following variables were significantly associated with undiagnosed diabetes: age as the predisposing factor; medical insurance, residential places and geographical regions as enabling factors; having other chronic diseases and self-perceived health status as need factors. Moreover, the prediction of regression model was assessed well in the form of ROC and AUC. Andersen model provided a theoretical framework for detecting variables of health service utilization, which may not only explain the undiagnosed reasons but also provide clues for policy-makers to balance health services among diverse social groups in China.

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