What characterizes effective tooth brushing of daily users of powered versus manual toothbrushes?

Background Recent data show comparable deficits in oral cleanliness after tooth brushing in habitual users of powered toothbrushes (PT) and manual toothbrushes (MT). The present analysis explores the origin of these deficits by relating aspects of the observed tooth brushing behaviour to plaque after tooth brushing. Methods Users of rotating-oscillating PT (N = 48) and of MT (N = 52) brushed their teeth the best they could while being filmed. Video analyses assessed brushing time, number of sextants brushed sufficiently long (7.5 s per surface; NSBSL), brushing of outer surfaces with closed jaws, and brushing movements. Correlation analyses examined the relationship between these parameters and plaque after brushing (Marginal Plaque Index (MPI); Turesky modification of Quigley Hein Index (TQHI)) and gingivitis (Papillary Bleeding Index (PBI)). Results In PT users, correlations between behaviour and MPI-scores were significant for the NSBSL (outer surfaces: rho = − 0.249; inner surfaces: rho = − 0.510) and brushing duration (outer surfaces: rho = − 0.399; inner surfaces: rho = − 0.509). In MT users, vertical movements on the outer surfaces were positively related to MPI (rho = 0.299). In contrast, circular movements correlated negatively with MPI in those who brushed all outer sextants sufficiently long (n = 47: rho = − 0.294). In both groups, PBI-scores on the inner surfaces were negatively correlated to NSBSL and brushing duration (rho = − 0.327 − rho = − 0.246). Conclusion NSBSL and brushing duration appear to play an important role for brushing effectiveness and gingival health in PT and MT users. Whether PT users apply brushing movements or not apparently does not affect the result. In MT users, circular movements seem to be more efficient than vertical movements on the outer surfaces.

The Independent Association Between Age and Serum Cholesterol Levels in Patients with Familial Hypercholesterolemia

(1) Background: Studies have suggested that age and the serum total cholesterol (TC) concentration are independent risk factors for cardiovascular disease (CVD) in patients with familial hypercholesterolemia (FH); however, the relationship between age and TC in patients with FH is unclear. We aimed to investigate the correlation between age and TC in patients with FH. (2) Methods: In this retrospective, controlled not matched analysis, a total of 103 patients with FH and 106 non-FH controls were recruited into the study from 2004 to 2017. Spearman and partial correlation analyses, as well as multiple regression analyses, were used to evaluate the relationship between TC and age. (3) Results: There were no significant differences in age, gender, or BMI between the FH group and the control group (p > 0.05). Family history of CVD, TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipoprotein (a) (Lp(a)) and non-HDL-C levels were significantly higher in patients with FH compared to the control (p < 0.01). Additionally, the serum TC levels for ages ≥ 50 years were significantly higher than those for ages < 50 years (p < 0.05) in FH patients. In both Spearman and partial correlation analyses, age was found to be significantly correlated with serum TC (p < 0.001) in the FH group but not in the control group, which was confirmed by further multiple linear regression analyses and logistic regression analyses. (4) Conclusions: Age is an independent factor influencing serum TC level in patients with FH, and it is necessary to conduct early screening and early intervention.

Gray Matter Atrophy And Corresponding Impairments In Connectivity In Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disease that is commonly accompanied by cognitive impairment and various neurological and psychiatric symptoms, advanced image analyses help explore the pathogenesis of this disease. Therefore, this study aimed to explore specific structural and functional alterations and their relationship with the clinical symptoms of anti-NMDAR encephalitis. In this study, twenty-two patients with anti-NMDAR encephalitis after the acute stage and 29 controls received cognitive assessments and magnetic resonance imaging. Grey matter atrophy was measured using voxel-based morphometry, and functional alterations in abnormal regions were subsequently investigated using resting state functional connectivity (RSFC). Finally, correlation analyses were performed to explore the associations between imaging alterations and cognitive assessments. The patients demonstrated significant gray matter atrophy in the bilateral triangle part of the inferior frontal gyrus (triIFG.L and triIFG.R) and right precuneus, decreased RSFC between triIFG.L and bilateral Heschl gyrus (HES), decreased RSFC between triIFG.R and HES.R, decreased RSFC between right precuneus and left cerebellum, and increased RSFC between triIFG.R and left superior frontal gyrus. Further correlation analyses showed that the gray matter volume in triIFG.R and decreased RSFC between triIFG.L and HES.R were associated with decreased memory scores, whereas decreased RSFC between triIFG.R and HES.R was marginally correlated with the disease course in patients. In conclusion, this study suggests that cognitive impairments in patients with anti-NMDAR encephalitis may be mainly associated with gray matter atrophy and abnormal RSFC in the triIFG. These findings provide new insights into anti-NMDAR encephalitis pathogenesis and help explore potential treatments.

Breakthrough Infections with SARS-CoV-2 in Vaccinated Students After a Festive Event - Identification of Risk Factors

We report an outbreak with SARS-CoV-2 breakthrough infections related to a festive event in Northern Bavaria, Germany in October 2021, with 24 of 95 participants infected. Correlation analyses among 16 interrogated variables revealed that duration at the event and conversation with the supposed index person were significant risk factors.

Shared genetic influences on depression and menopause symptoms

Background Women experience major depression and post-traumatic stress disorder (PTSD) approximately twice as often as men. Estrogen is thought to contribute to sex differences in these disorders, and reduced estrogen is also known to be a key driver of menopause symptoms such as hot flashes. Moreover, estrogen is used to treat menopause symptoms. In order to test for potential shared genetic influences between menopause symptoms and psychiatric disorders, we conducted a genome-wide association study (GWAS) of estrogen medication use (as a proxy for menopause symptoms) in the UK Biobank. Methods The analysis included 232 993 women aged 39–71 in the UK Biobank. The outcome variable for genetic analyses was estrogen medication use, excluding women using hormonal contraceptives. Trans-ancestry GWAS meta-analyses were conducted along with genetic correlation analyses on the European ancestry GWAS results. Hormone usage was also tested for association with depression and PTSD. Results GWAS of estrogen medication use (compared to non-use) identified a locus in the TACR3 gene, which was previously linked to hot flashes in menopause [top rs77322567, odds ratio (OR) = 0.78, p = 7.7 × 10−15]. Genetic correlation analyses revealed shared genetic influences on menopause symptoms and depression (rg = 0.231, s.e.= 0.055, p = 2.8 × 10−5). Non-genetic analyses revealed higher psychiatric symptoms scores among women using estrogen medications. Conclusions These results suggest that menopause symptoms have a complex genetic etiology which is partially shared with genetic influences on depression. Moreover, the TACR3 gene identified here has direct clinical relevance; antagonists for the neurokinin 3 receptor (coded for by TACR3) are effective treatments for hot flashes.

Microplastics interact with benthic biostabilization processes

Marine microplastics accumulate in sediments but impacts on ecosystem functions are poorly understood. Microplastics interactions with stabilizing benthic flora/fauna or biostabilization processes, have not been fully investigated, yet this is critical for unravelling microplastics effects on ecosystem-scale processes and functions. This is also vital for understanding feedback processes that may moderate the stock and flow of microplastics as they are transported through estuaries. The relationships between sedimentary microplastics, biota, environmental properties and sediment stability from field sediments, were examined using variance partitioning (VP) and correlation analyses. VP was used to identify common and unique contributions of different groups of variables (environmental, fauna and microplastic variables) to sediment stability. The influence of microplastic presence (fragment/fiber abundances and microplastic diversity) on sediment stability (defined using erosion thresholds and erosion rates) was demonstrated. Furthermore, microplastics appeared to mediate the biostabilizing effects of environmental properties (including microorganisms) and fauna. Environmental properties and sediment stability could also explain the variation in microplastics across sites suggesting biostabilizing properties may mediate the abundance, type and diversity of microplastics that accumulate in the bed. The potential for microplastics to influence biota and biostabilization processes and mediate microplastic resuspension dynamics within estuaries is discussed.

Media use, attention, mental health and academic performance among 8 to 12 year old children

The rise in digital media consumption, especially among children, raises the societal question of its impact on cognition, mental health and academic achievement. Here, we investigate three different ways of measuring technology use-—total hours of media consumed, hours of video game play and number of media used concurrently—-in 118 eight-to-twelve year-old children. At stake is the question of whether different technology uses have different effects, which could explain some of the past mixed findings. We collected data about children’s media uses as well as (i) attentional and behavioral control abilities, (ii) psychological distress, psychosocial functioning, and sleep, and (iii) academic achievement and motivation. While attentional control abilities were assessed using both cognitive tests and questionnaires, mental health and sleep were all questionnaire-based. Finally, academic performance was based on self-reported grades, with motivational variables being measured through the grit and the growth-mindset questionnaires. We present partial correlation analyses and construct a psychological network to assess the structural associations between different forms of media consumption and the three categories of measures. We observe that children consume large amounts of media and media multitask substantially. Partial correlation analyses show that media multitasking specifically was mostly correlated with negative mental health, while playing video games was associated with faster responding and better mental health. No significant partial correlations were observed for total hours on media. Psychological network analysis complement these first results by indicating that all three ways of consuming technology are only indirectly related to self-reported grades. Thus, technology uses appear to only indirectly relate to academic performance, while more directly affecting mental health. This work emphasizes the need to differentiate among technology uses if one is to understand how every day digital consumption impacts human behavior.

Changes in external ischial tuberosity width at varying trunk–thigh angles between sexes using two measurement methods

This study examined the influence of two methods and various trunk–thigh (TT) angles on external ischial tuberosity width (EITW) for 45 men and 45 women. In the experiment, the impress and seat pressure methods were applied at TT angles of 60°, 75°, 90°, and 105°. When the impress method was used, EITW remained highly consistent across the four measured TT angles with differences of 2.8 and 2.1 mm for men and women, respectively. Conversely, in the seated pressure method, EITW increased with TT angle such that differences in EITW across a full TT angle range were 11.5 and 11.7 mm for men and women, respectively. Irrespective of method, differences in EITW between genders measured approximately 12.6–13.7 mm across all TT angles. Correlation analyses revealed that hip circumference was positively related to EITW in all cases, whereas the relationship of hip width and depth with EITW varied by method and gender. Because of inherent differences in EITW between genders, these findings suggest that gender variability should be considered in seat cushion design.

The Correlation Analysis of Magnetic Susceptibility and Elemental Composition of Very Fine Sand from Anoi Itam Beach in Weh Island, Aceh

Ironsand deposits might contain Fe as well as other valuable elements and minerals that could be used in a variety of applications. Often, high Fe content deposits are preferable for exploration. An earlier study shows that the highest Fe content is found in the very fine sand (VFS) size. In this study, seven VFS samples from Anoi Itam were subjected to magnetic measurements as well as X-Ray florescence (XRF), X-Ray diffraction (XRD), and correlation analyses to investigate further characteristics and how magnetic susceptibility correlates with the elemental composition of ironsand. Magnetic susceptibility varies from 2207.77 × 10-8 m3 kg-1 to 4476.68 × 10-8 m3 kg-1. The main elements contained in the sample are Fe, Ti, Si, and Al. Meanwhile, other elements have small concentrations (<2%). Based on XRD analyses, magnetite and ilmenite are the main minerals with varying concentrations in each sample. The correlation analysis shows that magnetic susceptibility has a weak correlation with Fe probably because Fe forms minerals with very different magnetism, namely magnetite and ilmenite.