Validation Of Cariogram In Caries Prediction At Woman And Their Children 4 Years After Pregnancy – Longitudinal Randomized Control Study
Abstract Aim To evaluate Cariogram caries risk assessment during pregnancy with DMFT/dmft incidence at mother and children 4-years later.Background To validate baseline caries risk classifications according to Cariogram for pregnant women with the actual DMFT development after 4-year and the second aim was to validate assessed caries risk at pregnant women according to Cariogram with caries development at their children four years after.Methods The study population consisted of 96 pregnant women (average age 27, 4 years at baseline) that completed clinical baseline examination and salivary tests. A caries risk assessment was made using Cariogram model and according to it, participants were divided into five risk groups. The follow-up study was initiated 4 years later and the 80 pairs of mother and children (from that pregnancy) were re-examined using the same procedure as did at baseline. An individual caries risk profile and DMFT/dmft incidence were made for each woman and child. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for two cut-off were calculated to express the outcome.Results There was a strong association between the risk categories of pregnant women and their offspring as well as between caries development in children and the Cariogram risk categories of their mother in pregnancy. Sensitivity and PPV for new DMFT (ΔDMFT > 0) over 4 years for women was high (>80%) for those participants assessed with 0-60% “chance to avoid caries“, as well as diagnostic accuracy (74.00%). High specificity (91.00%), very high PPV (95.00%) and clinically useful values according to Youden’s index (0.53) were obtained for moderate and two lowest risk groups for dmft in children.Conclusions With the limits of this study, Cariogram was valid and highly predictive in caries risk assessment in children based on caries risk assessment of their mother in pregnancy. The Cariogram model can be useful tool for caries prediction in both groups of woman and their children based on caries risk assessment during pregnancy.