scholarly journals Health-related Quality of Life in long-term Prostate Cancer Survivors after Nerve-Sparing and Non-Nerve-Sparing Radical Prostatectomy – Results from the multiregional PROCAS study

2019 ◽  
Author(s):  
Salome Adam ◽  
Eva Martin-Diener ◽  
Bertrand Camey ◽  
Céline Egger Hayoz ◽  
Isabelle Konzelmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sexual Activity ◽  
Symptom Burden ◽  
Nerve Sparing ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Eortc Qlq

Abstract Background: Nerve-sparing (NS) surgery was developed to improve postoperative sexual and potentially urological outcomes after radical prostatectomy (RP). However, it is largely unknown how NSRP affects health-related quality of life (HRQoL) including urinary and sexual outcomes in prostate cancer (PC) survivors 5-10 years after diagnosis in comparison to Non-NSRP. Methods: The study population included 382 stage pT2-T3N0M0 PC survivors 5-10 years post-diagnosis, who were identified from the multiregional Prostate Cancer Survivorship in Switzerland (PROCAS) study. Briefly, in 2017/2018, PC survivors were identified via six population-based cancer registries based in both German- and French-speaking Switzerland. HRQoL and PC-specific symptom burden was assessed using the EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. Differences in HRQoL outcomes between survivors treated with NSRP (uni- & bilateral) and Non-NSRP were analysed with multivariable linear regression adjusted for age, years since diagnosis, cancer stage, comorbidities at diagnosis and further therapies, if appropriate. Multiple imputation was performed to minimize the bias due to missing data.Results: 5-10 years after diagnosis, PC survivors treated with NSRP and Non-NSRP reported similar symptom burden and comparable HRQoL function scores. The only significant differences were reported for sexual activity, whereas PC survivors who underwent NSRP reported statistically significant (p=0.031) higher sexual activity than those on Non-NSRP. NSRP and Non-NSRP reported similar scores for urinary symptoms and all other HRQoL outcomes. Conclusions: NSRP and Non-NSRP were generally associated with comparable long-term HRQoL outcomes, but NSRP was linked with significantly higher sexual activity scores than Non-NSRP. Our results support nerve-sparing techniques as an option to improve post-operative sexual but not urinary outcomes after RP in long-term PC survivors.

scholarly journals Health‐related quality of life in long‐term prostate cancer survivors after nerve‐sparing and non‐nerve‐sparing radical prostatectomy—Results from the multiregional PROCAS study

2020 ◽  
Vol 9 (15) ◽  
pp. 5416-5424
Author(s):  
Salome Adam ◽  
Eva Martin‐Diener ◽  
Bertrand Camey ◽  
Céline Egger Hayoz ◽  
Isabelle Konzelmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Nerve Sparing ◽  
Health Related Quality ◽  
Prostate Cancer Survivors ◽  
Related Quality ◽  
Health Related

The role of psychosocial resources for long-term breast, colorectal, and prostate cancer survivors: prevalence and associations with health-related quality of life

2018 ◽  
Vol 27 (1) ◽  
pp. 275-286 ◽  
Author(s):  
Daniela Doege ◽  
Melissa Thong ◽  
Lena Koch-Gallenkamp ◽  
Heike Bertram ◽  
Andrea Eberle ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cancer Survivors ◽  
Health Related Quality ◽  
Prostate Cancer Survivors ◽  
Related Quality ◽  
Health Related

736 PL11.04 HEALTH-RELATED QUALITY OF LIFE OF PATIENTS WITH ESOPHAGEAL CANCER FOLLOWING ESOPHAGECTOMY TREATED WITH NEOADJUVANT CHEMORADIOTHERAPY OR CHEMOTHERAPY: EUROPEAN MULTICENTER STUDY

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Nannet Schuring ◽  
Sheraz Markar ◽  
Eliza R C Hagens ◽  
Egle Jezerskyte ◽  
Mirjam A G Sprangers ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Neoadjuvant Chemoradiotherapy ◽  
P Value ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Mean ◽  
Eortc Qlq

Abstract   Curative treatment for patients with esophageal cancer consists of neoadjuvant treatment and radical surgical resection. Two different strategies exist; patients can either be treated with perioperative chemotherapy (CT) or neoadjuvant chemoradiotherapy (CRT). Both strategies improve 5-year survival rates, it is however not known if these treatments affect long-term Health-Related Quality of Life (HR-QoL) differently. The aim of this study was to compare HR-QoL between patients following CT and CRT followed by esophagectomy for esophageal cancer. Methods The LASER study database comprises data of a multicenter European study, with focus on HR-QoL among disease-free patients at least one year following an esophagectomy for esophageal or junctional cancer. Included patients completed the LASER, EORTC-QLQ-C30 and EORTC-QLQ-OG25 questionnaires. From this database we extracted patients either treated with CT or CRT for analysis. The primary endpoint was the mean difference in all long-term HR-QoL domains and LASER key symptom scores, using univariable and multivariable logistic regression analysis. The secondary endpoint was to compare the reported HR-QoL domain scores in the study population to the reference values of the general population. Results Among the 565 included patients, 349 (61.8%) received CRT, and 216 (38.2%) were treated with CT. The mean age was 63.7 years (±SD 8.6), and mean time since surgery was 4.3 years (±SD 1.7). After multivariable analysis, patients treated with CT reported worse outcomes on ‘Social Functioning’ (∆means 4.56, p-value<0.05), more symptomatology on domains ‘Insomnia’ (∆means 5.65 p-value<0.05) and ‘Diarrhea’ (∆means 5.93 p-value<0.05) of the QLQ-C30 questionnaire, and more symptomatology on domains ‘Reflux’ (∆means 7.40, p-value<0.05), ‘Odynophagia’(∆means 4.66 p-value<0.05) and ‘Pain and discomfort’(∆means 4.34, p-value<0.05) of the QLQ-OG25 questionnaire. No differences were observed for the LASER key symptoms. Conclusion Significant differences in favor of CRT were observed in several long-term HR-QoL domains for patients following esophagectomy for cancer. However, none of the observed differences in the reported long-term HR-QoL domains between patients treated with CT or with CRT, were clinically relevant (∆means≠ ≥ 10 points). Selection of neoadjuvant therapy should therefore be based on patient characteristics.

A meta-analysis of health-related quality of life after primary treatment for prostate cancer as measured by the Expanded Prostate Cancer Index Composite.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 39-39
Author(s):  
Nicholas RIchard Cnossen ◽  
Amber Gail Orman ◽  
Deukwoo Kwon ◽  
Chad Ritch ◽  
Mark Gonzalgo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Radiation Therapy ◽  
Meta Analysis ◽  
Primary Treatment ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

39 Background: Health-related quality of life (HRQoL) outcomes are important in treatment selection for prostate cancer. The Expanded Prostate Cancer Index Composite (EPIC) is a validated and widely-utilized HRQoL survey which accounts for newer radiotherapeutic, surgical, and hormonal treatment methods. We present a meta-analysis of patient reported HRQoL outcomes collected with EPIC and compare HRQoL trends with radiation therapy, surgery, or active surveillance as primary treatment. Methods: The PubMed database was systematically searched for all studies which presented data directly derived from the use of EPIC on patients with prostate cancer prior to 07/09/2014. All eligible studies were selected for either inclusion and analysis or exclusion based on pre-determined criteria. The data from included studies was compiled and a simulation-based estimation method using Approximate Bayesian Computation was performed to obtain missing standard deviation estimate. A longitudinal meta-analysis was conducted to estimate EPIC-profiles for each component using Bayesian p-spline method. Results: Over 4,000 studies were searched, 152 were deemed eligible, and 39 were included. The calculated mean summary score estimates are shown in the attached table. Conclusions: In the urinary domain, radical prostatectomy (RP) has lower acute scores than active surveillance (AS) or radiation therapy (RT) without long-term difference. In the bowel domain, RT has lower scores than AS or RP acutely and long-term. In the sexual domain, RT and RP have lower acute scores than AS. RP has lower scores than RT without long-term difference. In the hormonal domain, little difference was noted between modalities. [Table: see text]

scholarly journals Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry

2015 ◽  
Vol 68 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Sanoj Punnen ◽  
Janet E. Cowan ◽  
June M. Chan ◽  
Peter R. Carroll ◽  
Matthew R. Cooperberg
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Primary Treatment ◽  
Localized Prostate Cancer ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

PD18-03 LONG-TERM HEALTH RELATED QUALITY OF LIFE IN PROSTATE CANCER PATIENTS REQUIRING RADIOTHERAPY AFTER RADICAL PROSTATECTOMY

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Louis Aliperti ◽  
Dattatraya Patil ◽  
Akanksha Mehta ◽  
Christopher Filson ◽  
Catrina Crociani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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