Bremelanotide for Treatment of Female Hypoactive Sexual Desire

Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity, reduced responsiveness to erotic cues, a loss of interest during sexual activity, and avoidance of situations that could lead to sexual activity. The pathophysiology of HSDD is thought to be centered around inhibitory and excitatory hormones, neurotransmitters, and specific brain anatomy. Due to the multifactorial nature of HSDD, treatment can be complex and must attempt to target the biological and psychosocial aspects of the disorder. Bremelanotide is a melanocortin receptor agonist and has been recently approved by the FDA to treat HSDD. Bremelanotide is administered intranasally or as a subcutaneous injection. The recommended dosage of bremelanotide is 1.75 mg injected subcutaneously in the abdomen or thigh at least 45 min before sexual activity. Studies showed improvements in desire, arousal, and orgasm scores when 1.75 mg of bremelanotide was administered before sexual activity compared to a placebo. Bremelanotide is a promising way to treat HSDD.

Sexual function in primiparous women: a prospective study

Introduction and hypothesis The aim of this prospective study was to examine the impact of sociodemographic, pregnancy and obstetric characteristics on sexual function 12 months postpartum in primiparous women. We hypothesized that sexual function would decrease after childbirth. Methods Between 1 October 2014 and 1 October 2017, all nulliparous women in early pregnancy registering for maternity health care in Region Örebro County, Sweden, were invited to participate in this prospective study. A total of 958 women were included. Sexual activity and function were measured at early pregnancy, 8 weeks postpartum and 12 months postpartum using the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12). The associations between sociodemographic, pregnancy and obstetric characteristics and sexual activity and function from early pregnancy to 12 months postpartum were examined using linear and logistic models based on generalized estimating equations. Results We found that the prevalence of sexually active women decreased from 98.0% in early pregnancy to 66.7% at 8 weeks postpartum, but increased to 90.0% at 12 months postpartum. Age ≥ 35 years, second-degree perineal tear and current breastfeeding were statistically significant risk factors for sexual inactivity at 12 months postpartum. Poor self-reported health in early pregnancy was statistically significantly associated with decreased sexual function at 12 months postpartum. Conclusions A majority of women resumed sexual activity at 8 weeks postpartum and most women at 12 months postpartum; the decrease in sexual function at 12 months postpartum was small and few risk factors were observed.

Crime or Human Right?

To the Nigerian state, consensual sexual activity among persons of the same sex is against the order of nature and must be punished as a crime. On the other hand, to persons who engage in sexual activity with persons of the same gender and to rights' activists, the act is a right, like any other, which should be respected and protected. This chapter examines the cultural issues, the human rights angle, and the future of the criminalization of same-sex sexual conduct conundrum in Nigeria. Using the doctrinal method of legal research methodology, the chapter reviews laws criminalizing homosexuality in Nigeria in juxtaposition with human rights provisions both in the international and domestic context in search of a solution to the problem. Accordingly, it is recommended that while the law should protect cultural values, human rights are sacrosanct and must not be sacrificed.

Probiotics with estriol in the treatment of acute and recurrent vaginal and vulvar infections in women

The microbiome undergoes qualitative and quantitative changes at different times in a woman’s life, and their nature is due to many factors such as age, sexual activity, comorbidities, etc. As a result, vaginal dryness and inflammation can occur in the vagina. This problem is most important during the menopausal period, when estrogen secretion decreases – this induces a cascade of unfavorable biological effects. We can prevent them by adding probiotics to the standard menopausal hormonotherapy. Adding probiotics restore and maintain the proper microbiological condition of the vagina. The use of probiotics reduces the risk of developing ailments that require antibiotic therapy, which is also detrimental to the vaginal microbiome.

Non-disabled and disabled women sexual health comparison

Background: Disabled women constitute approximately 16% of all women in Europe. Regardless of disability level women are interested in maintaining sexual activity. The study aim was to compare, understand if there are sexual health disparities between disabled women and non-disabled women.Methods: A cross-sectional study was conducted in non-governmental associations and the general practitioner's office in Latvia from November 2018 to January 2019. Data were collected from self-filled questionnaires of 34 DW and 34 NDW.Results: The mean age of NDW was 32 years and 43 years for DW. 73.5% of DW and 41.2% of NDW were partially satisfied with their sex life, p=0.009. 47.1% of DW and 32.4% of NDW admitted having an irregular sex life, p=0.002. 58.8% of NDW and 29.4% of DW had last sexual intercourse within 6 days period, p=0.011. 67.6% NDW and 20.6% DW thought their sex life will improve in future, p=0.001. 70.6% of DW was interested in maintaining sexual relations as well as 91.2% of NDW. 20.6% of DW was interested in maintaining sexual relationships but less than before disability. 29.4% of respondents from both groups noted that the level of disability or other health disorders had little impact on their sexual health. 8.8% of disabled women and 2.9% of non-disabled women had severe symptoms of depression.Conclusions: The study demonstrated that NDW had regular sex life and were more satisfied with it than DW. Regardless of the state of health women were interested in maintaining sexual activity.

Working Under the Myth of the Black Rapist

Chapter 5 posits that the journey for Black boys adopting anti-violent perspectives is substantially different than that of their White peers because they must operate under negative tropes about their propensity for aggression: There is a belief that Black men have a special propensity for forcefully acting out their sexual desires on women. “The myth of the Black rapist” is identified as a term, and the author provides contemporary and historical evidence of its existence. Examples can be found in the criminal justice system and pornography. Chapter 5 reminds readers that caution in initiating sexual activity is an appropriate standard and closes with a challenge that Black men overcome historical stereotypes by becoming recognized advocates for anti-violence.

Association between Anxious and Depressive Symptomatology and Sexual Activity in Spain: A Cross-Sectional Study during the COVID-19 Quarantine

Introduction: Evidence on sexual behaviour and COVID-19 shows a change in sexual habits; however, there is no research on the association between mental health and sexual activity. Aim: To examine the relationship between mental health and sexual activity during the quarantine in Spanish adults. Methods: A sample of 305 adults filled out an online questionnaire. Sexual activity was assessed with one question. Anxiety and depression symptoms were assessed using the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory (BDI), respectively. To check associations between levels of both anxiety and depressive symptoms (exposure) and weekly prevalence of sexual activity (outcome), we conducted multiple logistic regression adjusted for control variables (marital status, employment, average household annual income, place of living, pre-COVID-19 sexual activity, current smoking, current alcohol consumption, chronic physical conditions, chronic psychiatric conditions, physical symptoms, and days of confinement). Results: Higher depression level was associated with lower weekly sexual activity in a dose-response fashion in the three implemented models. Participants with higher levels of depression were associated with significantly lower sexual activity in the fully adjusted model (OR: 0.09, 95% CI 0.01–0.61). Mild anxiety-level participants consistently presented significantly lower ORs for lower sexual activity than their minimal-anxiety category counterparts. Particularly, the fully adjusted model showed the lower values (OR: 0.40, 95% CI 0.19–0.84). Conclusion: The results of this study support existing evidence stressing the association between mental health and sexual activity in quarantined adults.

Online child sexual offenders' language use in real-time chats

We analysed chat log communications between 38 adult males and children who were accessed by the men via social media for sexually exploitative purposes. Our goal was to understand how sexual offenders engage with children online and the dialogue they use to elicit compliance with sexual requests. Results revealed 72 discrete linguistic tactics, contained within eight overarching dialogue-based ‘moves’. Tactics were non-sequential (ie dynamic) and focused mainly on requests for sexual activity. Three distinct subgroup patterns of tactic use were evident. Implications for theory and practice are discussed.

Effect of Aqueous Extract of Rauvolfia vomitoria (Apocynaceae) Leaves with on Sexual Activity of Male Rats

Objective: The aim of this study is to determine the pharmacological effects of Rauvolfia vomitoria leaves on the sexual activity of animal model (male rat) Methods: Acute toxicity was performed according to OECD Guideline 423, by a dose limit of 2000 mg /kg body weight. The observations (during 14 days) focused on the number of deaths, convulsions, sleep and coma. Study of sexual activity has been realized by using 20 male rats, distributed in 4 lots of 5 animals. Group 1 treated with distilled water, group 2 treated with 5 mg/kg B.W. of sildenafil citrate and the other two batches received respectively the doses 500 and 1000 mg/kg of the aqueous extract of Rauvolfia vomitoria. Females in estrus state (in heat) were introduced for a period of 30 minutes. During this period, parameters of sexual behavior were recorded. At the end of the 8-day treatment, organs such as penis testicles, seminal vesicles, prostate, epididymis and elevator muscle were removed. These organs were studied in order to determine pharmacological effects of aqueous extract of Rauvolfia vomitoria. Results: The aqueous extract of Rauvolfia vomitoria showed no evidence of single dose toxicity (2000 mg/kg) when studying acute toxicity. Ride latency time, coitus latency time and ejaculation latency time was significantly decreased (P<0.001) with regard to negative control (distilled water). Ride frequency, coitus fraquency and ejaculation frequency was significantly increased (P<0.001) with regard to negative control (distilled water). No significant difference (P˃0.05) has been recorded on organ androgeno-dependant. Conclusion: Aqueous extract of R. vomitoria has sexual stimulating activity or an aphrodisiac potential which could justify its traditional use. The aphrodisiac potential is higher at the dose of 1000 mg/kg b.w .