scholarly journals Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

2020 ◽  
Author(s):  
Jiaqi Zhou ◽  
Feng Xue ◽  
Xingtao Zhou ◽  
Rajeev Krishnan Naidu ◽  
Yishan Qian
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Prospective Study ◽  
Corneal Epithelium ◽  
Fourier Domain ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness ◽  
A Prospective Study ◽  
Lens Wear

Abstract Background: To investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.Methods: A prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Results: Visual acuity and refraction improved significantly after OK lens wear. △ETFm (-4.2±3.4μm) thinned more than △ETSm (-3.4±4.0μm, P=0.027) at 1.5mm in radius. △ETSm thickened more than △ETFm at 2.5mm (△ETSm: 4.1±5.1μm, △ETFm: 2.8±4.2μm, P=0.019) and 3.0mm (△ETSm: 5.0±5.0μm, △ETFm: 3.7±4.9μm, P=0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0mm, 2.5mm and 3.0mm (2.0mm: r=0.285, P=0.032; 2.5mm: r=0.422, P=0.001; 3.0mm: r=0.239, P=0.027). ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5mm (r=0.299, P=0.028). Conclusions: Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.

scholarly journals Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

2020 ◽  
Author(s):  
Jiaqi Zhou ◽  
Feng Xue ◽  
Xingtao Zhou ◽  
Rajeev Krishnan Naidu ◽  
Yishan Qian
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Prospective Study ◽  
Corneal Epithelium ◽  
Fourier Domain ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness ◽  
A Prospective Study ◽  
Lens Wear

Abstract Background: To investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. Methods: A prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Results: Visual acuity and refraction improved significantly after OK lens wear. △ETFm (-4.2±3.4μm) thinned more than △ETSm (-3.4±4.0μm, P=0.027) at 1.5mm in radius. △ETSm thickened more than △ETFm at 2.5mm (△ETSm: 4.1±5.1μm, △ETFm: 2.8±4.2μm, P=0.019) and 3.0mm (△ETSm: 5.0±5.0μm, △ETFm: 3.7±4.9μm, P=0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0mm, 2.5mm and 3.0mm (2.0mm: r=0.285, P=0.032; 2.5mm: r=0.422, P=0.001; 3.0mm: r=0.239, P=0.027). ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5mm (r=0.299, P=0.028). Conclusions: Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.

scholarly journals Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

2019 ◽  
Author(s):  
Jiaqi Zhou ◽  
Feng Xue ◽  
Xingtao Zhou ◽  
Rajeev Krishnan Naidu ◽  
Yishan Qian
Keyword(s):  
Visual Acuity ◽  
Corneal Epithelium ◽  
Fourier Domain ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
The Mean ◽  
A Prospective Study ◽  
Age Range ◽  
Corneal Apex ◽  
Lens Wear

Abstract Background: To investigate the changes in the corneal epithelial thickness along the steep (ETS) and flat (ETF) meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.Methods: A prospective study. Fifty-seven subjects (age range: 9–38 years) with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses in both eyes for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal topography were performed at baseline and after 6 months’ of overnight OK lens wear. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the central corneal epithelial topography along varying meridians over a diameter of 6mm. The values of epithelial thickness (ET) along the steep and flat meridians were recorded at 1mm intervals from the corneal apex to the mid-periphery along chords with a diameter of 6mm（Φ6mm）and compared between pre- and post-lens wear (change of ET at the steep meridian: △ETS; change of ET at the flat meridian: △ETF). The mean of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Results: Visual acuity and refraction improved significantly after OK lens wear. The central corneal epithelium thinned and the mid-peripheral corneal epithelium thickened after OK lens wear (P < 0.05). ETFm thinned more than ETSm atΦ3mm andΦ4mm and ETSm thickened more than ETFm atΦ5mm andΦ6mm. Conclusions: The corneal epithelium thinned more along the flat meridian of the paracentral cornea and thickened more along the steep meridian of the mid-peripheral cornea after spherical OK lens wear.

Reliability and Reproducibility of Assessment of Corneal Epithelial Thickness by Fourier Domain Optical Coherence Tomography

2012 ◽  
Vol 53 (6) ◽  
pp. 2580 ◽  
Author(s):  
Gaurav Prakash ◽  
Amar Agarwal ◽  
Anjum Iqbal Mazhari ◽  
Mathangi Chari ◽  
Dhivya Ashok Kumar ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus

2015 ◽  
Vol 41 (4) ◽  
pp. 812-820 ◽  
Author(s):  
Cyril Temstet ◽  
Otman Sandali ◽  
Nacim Bouheraoua ◽  
Taous Hamiche ◽  
Alice Galan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Reproducibility and Daytime-Dependent Changes of Corneal Epithelial Thickness and Whole Corneal Thickness Measured With Fourier Domain Optical Coherence Tomography

Cornea ◽  
2016 ◽  
Vol 35 (3) ◽  
pp. 342-349 ◽  
Author(s):  
Joanna Wasielica-Poslednik ◽  
Walter Lisch ◽  
Katharina Bell ◽  
Veronika Weyer ◽  
Norbert Pfeiffer ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

scholarly journals Corneal epithelial thickness analysis of forme fruste keratoconus with optical coherence tomography

2021 ◽  
Vol 14 (1) ◽  
pp. 89-96
Author(s):  
Xiao-Long Yang ◽  
◽  
Bao-Gen Luo ◽  
Yue Xu ◽  
Xiao-Feng Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Epithelium ◽  
Optical Coherence ◽  
Topographic Map ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Central Island ◽  
Epithelial Remodeling ◽  
Corneal Epithelial Thickness ◽  
Forme Fruste Keratoconus

AIM: To explore the significance of corneal epithelial thickness analysis in diagnosing early keratoconus. METHODS: There were 26 clinical keratoconus, 21 forme fruste keratoconus, 40 high corneal astigmatism (ΔK) and 40 low ΔK eyes involved in the study. Fourier-domain optical coherence tomography was used to measure the corneal epithelial thickness of four groups. The morphological features of topographic map and the thickness of corneal epithelial thinnest point were analyzed. The distribution curve of corneal epithelial thickness at 45°, 90°, and 135° axial directions that are through the pupil center was also analyzed. One-way ANOVA was performed to compare the data. RESULTS: The topographic map of forme fruste keratoconus corneal epithelial thickness was uniformity shape; crater shape existed only in clinical keratoconus group; and central island shape mainly existed in high ΔK group. The thinnest point of corneal epithelial thickness of forme fruste keratoconus group was significantly lower than that of low ΔK group (P=0.022). The thickness of corneal epithelium in the forme fruste keratoconus at 90° was thinner than that in the low astigmatism group at -1, and -2 mm points (P-1 mm=0.015, P-2 mm=0.036). CONCLUSION: The analysis of the thinnest point in forme fruste keratoconus corneal epithelium appears earlier than corneal epithelial remodeling. The topographic map of corneal epithelium in high ΔK eyes appears in central island shape, and can be used for the differential diagnosis of early keratoconus.

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