scholarly journals Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

2019 ◽  
Author(s):  
Jiaqi Zhou ◽  
Feng Xue ◽  
Xingtao Zhou ◽  
Rajeev Krishnan Naidu ◽  
Yishan Qian
Keyword(s):  
Visual Acuity ◽  
Corneal Epithelium ◽  
Fourier Domain ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
The Mean ◽  
A Prospective Study ◽  
Age Range ◽  
Corneal Apex ◽  
Lens Wear

Abstract Background: To investigate the changes in the corneal epithelial thickness along the steep (ETS) and flat (ETF) meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.Methods: A prospective study. Fifty-seven subjects (age range: 9–38 years) with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses in both eyes for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal topography were performed at baseline and after 6 months’ of overnight OK lens wear. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the central corneal epithelial topography along varying meridians over a diameter of 6mm. The values of epithelial thickness (ET) along the steep and flat meridians were recorded at 1mm intervals from the corneal apex to the mid-periphery along chords with a diameter of 6mm（Φ6mm）and compared between pre- and post-lens wear (change of ET at the steep meridian: △ETS; change of ET at the flat meridian: △ETF). The mean of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Results: Visual acuity and refraction improved significantly after OK lens wear. The central corneal epithelium thinned and the mid-peripheral corneal epithelium thickened after OK lens wear (P < 0.05). ETFm thinned more than ETSm atΦ3mm andΦ4mm and ETSm thickened more than ETFm atΦ5mm andΦ6mm. Conclusions: The corneal epithelium thinned more along the flat meridian of the paracentral cornea and thickened more along the steep meridian of the mid-peripheral cornea after spherical OK lens wear.

scholarly journals Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

2020 ◽  
Author(s):  
Jiaqi Zhou ◽  
Feng Xue ◽  
Xingtao Zhou ◽  
Rajeev Krishnan Naidu ◽  
Yishan Qian
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Prospective Study ◽  
Corneal Epithelium ◽  
Fourier Domain ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness ◽  
A Prospective Study ◽  
Lens Wear

Abstract Background: To investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. Methods: A prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Results: Visual acuity and refraction improved significantly after OK lens wear. △ETFm (-4.2±3.4μm) thinned more than △ETSm (-3.4±4.0μm, P=0.027) at 1.5mm in radius. △ETSm thickened more than △ETFm at 2.5mm (△ETSm: 4.1±5.1μm, △ETFm: 2.8±4.2μm, P=0.019) and 3.0mm (△ETSm: 5.0±5.0μm, △ETFm: 3.7±4.9μm, P=0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0mm, 2.5mm and 3.0mm (2.0mm: r=0.285, P=0.032; 2.5mm: r=0.422, P=0.001; 3.0mm: r=0.239, P=0.027). ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5mm (r=0.299, P=0.028). Conclusions: Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.

scholarly journals Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology

2020 ◽  
Author(s):  
Jiaqi Zhou ◽  
Feng Xue ◽  
Xingtao Zhou ◽  
Rajeev Krishnan Naidu ◽  
Yishan Qian
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Prospective Study ◽  
Corneal Epithelium ◽  
Fourier Domain ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness ◽  
A Prospective Study ◽  
Lens Wear

Abstract Background: To investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.Methods: A prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Results: Visual acuity and refraction improved significantly after OK lens wear. △ETFm (-4.2±3.4μm) thinned more than △ETSm (-3.4±4.0μm, P=0.027) at 1.5mm in radius. △ETSm thickened more than △ETFm at 2.5mm (△ETSm: 4.1±5.1μm, △ETFm: 2.8±4.2μm, P=0.019) and 3.0mm (△ETSm: 5.0±5.0μm, △ETFm: 3.7±4.9μm, P=0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0mm, 2.5mm and 3.0mm (2.0mm: r=0.285, P=0.032; 2.5mm: r=0.422, P=0.001; 3.0mm: r=0.239, P=0.027). ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5mm (r=0.299, P=0.028). Conclusions: Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.

Effect of Age on Individual Corneal Epithelial Thickness in Normal Eyes as Measured with Ultrasound Pachymeter

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Corneal Epithelium ◽  
Corneal Thickness ◽  
Age Groups ◽  
Age Group ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Significant Difference ◽  
The Mean ◽  
Corneal Epithelial Thickness ◽  
Ultrasound Pachymeter

Purpose: The goal of this study was to determine age-relatedvariation in the thickness of the corneal epithelium using ultrasound pachymeter. Methods: One hundred three patients were enrolled in this study and grouped according to age: Group A (< 30 years), group B (31-40 years), group C (41-50 years), group D (51-60 years), group E (61-70), and group F (> 71). Total corneal and corneal epithelial thickness measurements were made using the SonogageCorneo-Gage Plus 2 (Cleveland, Ohio) ultrasound pachymeter. Correlations of central epithelial thickness with central total corneal thickness, age, and gender were calculated. In addition, mean central epithelial thickness (CET) was measured. One-way ANOVA testing and post hoc analysis with the Tukey test and Pearson correlation were performed to analyze data. Results: The mean epithelial thickness at the central cornea was 47.88±1.15 μm, with no statistically significant difference between right and left eyes, and no significant differences in gender or central total corneal thickness. The difference in mean epithelial thickness across age groups was statistically significant (p <0.008). The mean epithelial thickness of the > 71 years group was significantly thinner than that of the < 30 years, 31-40, 41-50, and 51-60 years age groups. Conclusions: Ultrasound pachymeter of the corneal epithelium demonstrated that the oldest age group (> 71 years) had significantly thinner central corneal epithelial thickness than the younger age groups. There was no correlation between epithelial thickness, total corneal thickness, gender, or laterality.

Reliability and Reproducibility of Assessment of Corneal Epithelial Thickness by Fourier Domain Optical Coherence Tomography

2012 ◽  
Vol 53 (6) ◽  
pp. 2580 ◽  
Author(s):  
Gaurav Prakash ◽  
Amar Agarwal ◽  
Anjum Iqbal Mazhari ◽  
Mathangi Chari ◽  
Dhivya Ashok Kumar ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus

2015 ◽  
Vol 41 (4) ◽  
pp. 812-820 ◽  
Author(s):  
Cyril Temstet ◽  
Otman Sandali ◽  
Nacim Bouheraoua ◽  
Taous Hamiche ◽  
Alice Galan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

scholarly journals Redistribution of the Corneal Epithelium After Overnight Wear of Orthokeratology Contact Lenses for Myopia Reduction

2018 ◽  
Author(s):  
Ju Zhang ◽  
Jing Li ◽  
Xiaofeng Li ◽  
Fengjie Li ◽  
Ting Wang
Keyword(s):  
Visual Acuity ◽  
Corneal Epithelium ◽  
Contact Lenses ◽  
Early Stage ◽  
Corneal Thickness ◽  
Topographic Map ◽  
Epithelial Thickness ◽  
Uncorrected Visual Acuity ◽  
Before And After ◽  
Epithelium Thickness

Abstract Background: To investigate changes in the corneal epithelium topographic map in juvenile myopia after overnight wear of orthokeratology lenses (OK). Methods: A total of 53 juveniles (53 right eyes) successfully wore OK and were reviewed in a timely manner from January 2016 to July 2017. Epithelial and corneal data were obtained by optical coherence tomography (OCT). Changes in uncorrected visual acuity, diopter, corneal refractive power, and epithelial and corneal thickness were analyzed before and after 1 day, 1 week, and 1 mo of overnight wear of OK. Results: The corneal epithelium was reshaped after 1 day of OK; the myopia degree was reduced, and uncorrected visual acuity reached 0 logMAR at 1 week. The central (2-mm) average epithelial thickness was 52.04±2.35 μm, 49.25±2.67 μm, 45.91±2.80 μm, and 47.53±3.44 μm before and after 1 day, 1 week, and 1 mo of OK, respectively (t=10.122, 10.782, and 10.673, respectively, P≤0.001). The central epithelium appeared to have a thinning trend, which was obvious at 1 week, when the average thinning of 6.13±1.67 μm accounted for approximately 11.78%±3.21% of the total epithelium thickness. The epithelial thickness of the reverse curve zone was 51.83±2.49 μm, 57.62±3.01 μm, 59.43±3.19 μm, and 60.22±2.75 μm before and after 1 day, 1 week, and 1 mo of OK, respectively, showing a significant increase over time (t=5.325, 6.177, and 6.312, respectively, P≤0.001). Conclusion: In the early stage of OK, the corneal epithelium was redistributed very quickly. The central epithelium became thin, while the epithelium of the reverse curve zone correspondingly thickened and achieved a plateau at 1 mo. Epithelial redistribution guaranteed uncorrected visual acuity after removal of OK.

scholarly journals Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0239124
Author(s):  
Juliette Buffault ◽  
Pierre Zéboulon ◽  
Hong Liang ◽  
Anthony Chiche ◽  
Jade Luzu ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Normal Subjects ◽  
Optical Quality ◽  
Quality Analysis ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Epithelial Basement Membrane ◽  
The Mean ◽  
Corneal Epithelial Thickness ◽  
Epithelial Basement

Purpose To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD). Methods 45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects were enrolled. All participants were subjected to 9-mm corneal epithelial mapping with OCT and vision quality was assessed with the optical quality analysis system using the objective scatter index (OSI). Central, superior, inferior, minimum, maximum, and standard deviation of epithelium thickness (Irregularity), were analysed and correlations with the OSI were calculated. Results The mean (±SD) central, inferior and maximum epithelial thicknesses of the EBMD patients (respectively, 56.4 (±8.1) μm, 58.9 (±6.4) μm, and 67.1 (±8.3) μm) were thicker compared to DED patients (P<0.05) and normal subjects (P<0.05). We found greater irregularity of epithelial thickness in EBMD (5.1±2.5 μm) compared to DED patients (2.6±1.0 μm) (P = 4.4.10−6) and normal subjects (2.1±0.7 μm) (P = 7.6.10−7). The mean OSI was worse in EBMD patients than in DED patients (P = 0.01) and compared to normal subjects (P = 0.02). The OSI correlated with the epithelial thickness irregularity (Spearman coefficient = 0.54; P = 2.65.10−5). Conclusions The OCT pachymetry map demonstrated that EBMD patients had thicker corneal epithelium in the central and inferior region. These changes were correlated with objective measurements of vision quality. This OCT characterisation of the EMBD provides a better understanding of the epithelial behaviour in this dystrophy and its role in vision quality.

scholarly journals Role of α1-adrenoceptor subtypes on corneal epithelial thickness and cell proliferation in mice

2018 ◽  
Vol 315 (5) ◽  
pp. C757-C765 ◽  
Author(s):  
Aytan Musayeva ◽  
Caroline Manicam ◽  
Andreas Steege ◽  
Christoph Brochhausen ◽  
Beate K. Straub ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Cell Size ◽  
Corneal Epithelium ◽  
Messenger Rna ◽  
Rank Order ◽  
Wild Type ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Adrenergic stimuli are important for corneal epithelial structure and healing. The purpose of the present study was to examine the hypothesis that the lack of a single α1-adrenoceptor (α1-AR) subtype affects corneal epithelial thickness and cell proliferation. Expression levels of α1-AR mRNA were determined in mouse cornea using real-time PCR. In mice devoid of one of the three α1-AR subtypes (α1A-AR−/−, α1B-AR−/−, α1D-AR−/−) and in wild-type controls, thickness of individual corneal layers, the number of epithelial cell layers, and average epithelial cell size were determined in cryosections. Endothelial cell density and morphology were calculated in corneal explants, and epithelial cell proliferation rate was determined with immunofluorescence microscopy. Moreover, the ultrastructure of the corneal epithelium was examined by transmission electron microscopy. Messenger RNA for all three α1-AR subtypes was expressed in whole cornea and in corneal epithelium from wild-type mice with a rank order of abundance of α1A ≥ α1B > α1D. In contrast, no α1-AR mRNA was detected in the stroma, and only α1B-AR mRNA was found in the Descemet endothelial complex. Remarkably, corneal epithelial thickness and mean epithelial cell size were reduced in α1A-AR−/− mice. Our findings suggest that the α1A-AR exerts growth effects in mouse corneal epithelial cells.

Reproducibility and Daytime-Dependent Changes of Corneal Epithelial Thickness and Whole Corneal Thickness Measured With Fourier Domain Optical Coherence Tomography

Cornea ◽  
2016 ◽  
Vol 35 (3) ◽  
pp. 342-349 ◽  
Author(s):  
Joanna Wasielica-Poslednik ◽  
Walter Lisch ◽  
Katharina Bell ◽  
Veronika Weyer ◽  
Norbert Pfeiffer ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

The Effectiveness of Corneal Epithelial Debridement Performed with an Alcohol-Impregnated Sponge

2021 ◽  
Author(s):  
Deniz Altinbay ◽  
Ibrahim Taskin
Keyword(s):  
Clinical Outcomes ◽  
Corneal Epithelium ◽  
Cross Linking ◽  
Spherical Equivalent ◽  
Corneal Surgery ◽  
Corneal Epithelial ◽  
The Mean

AbstractObjective To evaluate the clinical outcomes of patients who underwent corneal surgery with debridement of epithelium by localised application of an alcohol-impregnated sponge instead of the usual alcohol reservoir method.Design This study retrospectively included 52 eyes of 27 patients who underwent LASEK (laser-assisted subepithelial keratectomy) and CXL (cross-linking) surgery after application of this alcohol-assisted debridement method between January 2019 and April 2019.Participants Twenty-four patients who underwent LASEK and three patients who underwent CXL surgery were included in this study, which comprised a total of 52 eye operations.Methods Epithelial debridement was performed after placing a 20% ethanol-impregnated sponge on the cornea for 20 seconds.Results The mean pachymetry value was 509.40 ± 30.37 µm, the mean preoperative spherical equivalent was − 2.14 ± 1.02 dioptres, and the highest myopia and astigmatism values were − 4.25 dioptres and − 2.75 dioptres, respectively. It was seen that the corneal epithelium was completely and easily debrided in a size identical to that of the applied sponge.Conclusions Complete debridement of the corneal epithelium can be performed quickly, safely, and easily with this specially prepared sponge.

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