scholarly journals LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

2020 ◽  
Author(s):  
Yi Zheng ◽  
Meng Wang ◽  
Shuqian Wang ◽  
Peng Xu ◽  
Yujiao Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Structure Prediction ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Statistical Significance ◽  
Case Control ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Control Study

Abstract Background: LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women. Methods: This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results: Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer (GG vs. TT: OR(95%) = 0.67(0.45-0.99), P = 0.042; GG vs. TT + TG: OR(95%) = 0.69(0.48-0.99), P = 0.046), especially for women aged <=49 (GG vs. TT: OR(95%) = 0.40(0.22-0.73), P = 0.02). Comparison between case groups showed genotype GG and TG/GG of rs3087918 were correlated with her-2 receptor expression (GG vs. TT: OR(95%) = 2.37(1.24-4.63), P = 0.010; TG + GG vs. TT: OR(95%) = 1.50(1.01-2.24), P = 0.045). We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated that rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions: MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG may increase the risk of breast cancer.

scholarly journals LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

2020 ◽  
Author(s):  
Yi Zheng ◽  
Meng Wang ◽  
Shuqian Wang ◽  
Peng Xu ◽  
Yujiao Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Structure Prediction ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Statistical Significance ◽  
Case Control ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Control Study

Abstract Background: LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women. Methods: This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results: Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer [GG vs. TT: OR(95%) = 0.67(0.45-0.99), P = 0.042; GG vs. TT + TG: OR(95%) = 0.69(0.48-0.99), P = 0.046], especially for women aged <=49 [GG vs. TT: OR(95%) = 0.40(0.22-0.73), P = 0.02]. Comparison between case groups showed genotype GG and TG/GG of rs3087918 were associated with her-2 receptor expression [GG vs. TT: OR(95%) = 2.37(1.24-4.63), P = 0.010; TG + GG vs. TT: OR(95%) = 1.50(1.01-2.24), P = 0.045]. We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated that rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions: MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG may increase the risk of breast cancer.

scholarly journals LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

2020 ◽  
Author(s):  
Yi Zheng ◽  
Meng Wang ◽  
Shuqian Wang ◽  
Peng Xu ◽  
Yujiao Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Structure Prediction ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Statistical Significance ◽  
Breast Cancer Susceptibility ◽  
Case Control ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Control Study

Abstract Background LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility. Methods This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequence MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer (GG vs. TT: P = 0.042; GG vs. TT + TG: P = 0.046), especially for women aged 49 and above (GG vs. TT: P = 0.02). Comparison between case groups showed genotype GG and TG/GG of rs3087918 were correlated with her-2 receptor expression (GG vs. TT: P = 0.010; TG + GG vs. TT: P = 0.045). We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG (SNP sequence: rs3087918, rs11160608, rs7158663) may increase the risk of breast cancer. And the protest effect of rs3087918 on breast cancer may owe to its effect on the structure and function of MEG3.

scholarly journals Polymorphisms in TIM-3 and breast cancer susceptibility in Chinese women: A case-control study

Oncotarget ◽  
2016 ◽  
Vol 7 (28) ◽  
pp. 43703-43712 ◽  
Author(s):  
Zheng Wang ◽  
Xinghan Liu ◽  
Xijing Wang ◽  
Tie Chong ◽  
Shuai Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Breast Cancer Susceptibility ◽  
Case Control ◽  
Control Study

Impact of Cyp1A1 and Comt Genotypes on Breast Cancer Risk in Mexican Women: A Pilot Study

2010 ◽  
Vol 25 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Mónica Moreno-Galván ◽  
Norma Estela Herrera-González ◽  
Vera Robles-Pérez ◽  
Julio C. Velasco-Rodríguez ◽  
Roberto Tapia-Conyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Case Control ◽  
Mexican Women ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Pcr Rflp ◽  
Control Study

Background Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. Objective The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. Material and methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP. Results The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04–6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05–10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found. Conclusions This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.

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